Mammary Cell News 11.39 October 10, 2019 | |
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TOP STORYUsing a progesterone+/glucocorticoid (GR)+ breast cancer cell line, the authors report that either glucocorticoid-free or dexamethasone-activated GR inhibited progestin-dependent gene expression associated to epithelial-mesenchymal-transition and cell proliferation. [Nucleic Acids Res] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Modeling Breast Cancer Using CRISPR/Cas9-Mediated Engineering of Human Breast Organoids Researchers demonstrated that breast epithelial organoids could be generated from human reduction mammoplasties, thus creating a tool to study the clonal evolution of breast cancer. To recapitulate de novo oncogenesis, they exploited CRISPR/Cas9 for targeted knock-out of four breast cancer-associated tumor suppressor genes in mammary progenitor cells from six donors. [J Natl Cancer Inst] Abstract SOD2 Acetylation on Lysine 68 Promotes Stem Cell Reprogramming in Breast Cancer Acetylated SOD2 promoted hypoxic signaling via increased mitochondrial reactive oxygen species (mtROS). mtROS, in turn, stabilized hypoxia-induced factor 2α, a transcription factor upstream of “stemness” genes such as Oct4, Sox2, and Nanog. [Proc Natl Acad Sci USA] Abstract Chemotherapy-Induced Senescent Cancer Cells Engulf Other Cells to Enhance Their Survival Using time-lapse and confocal microscopy to observe interactions of cells in treated tumors, scientists showed that chemotherapy-induced senescent cells frequently engulf both neighboring senescent or nonsenescent tumor cells at a remarkable frequency. Engulfed cells were processed through the lysosome and broken down, and cells that engulfed others obtained a survival advantage. [J Cell Biol] Abstract Investigators provided a single-cell resource of chromatin accessibility for murine mammary development from the peak of fetal mammary stem cell functional activity in late embryogenesis to the differentiation of adult basal and luminal cells. They found that the chromatin landscape within individual cells predicts both gene accessibility and transcription factor activity. [Cell Rep] Full Article | Graphical Abstract HUNK Phosphorylates EGFR to Regulate Breast Cancer Metastasis The authors showed that hormonally up-regulated neu-associated kinase (HUNK) phosphorylated epidermal growth factor receptor (EGFR) at T654, enhancing receptor stability and downstream signaling. They found that increased phosphorylation of T654 EGFR correlated with increased epithelial to mesenchymal, migration and invasion, and metastasis. [Oncogene] Full Article Lin Inhibition of LINC02582 expression increased radiosensitvity, while overexpression of LINC02582 promoted radioresistance. Mechanistically, LINC02582 interacted with deubiquitinating enzyme ubiquitin specific peptidase 7 to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance. [Cell Death Dis] Full Article Scientists evaluated the role of N-glycosylation of epithelial cell adhesion molecule (EpCAM) in stemness and epithelial–mesenchymal transition (EMT) characteristics. EpCAM overexpression increased the expression of stemness markers and EMT markers under the condition of hypoxia in breast cancer. [J Cell Physiol] Abstract The D-alpha-tocopheryl polyethylene glycol succinate-YM155 combination acted synergistically to reduce specifically the viability of SKBR3 cells. The combination of these agents reduced activation of the AKT pathway, decreased survivin and Bcl-2 levels, and induced caspase-dependent and independent apoptosis via the mitochondrial pathway. [Sci Rep] Full Article Treatment with demethylating agent 5-azacytidine increased the expression of E-cadherin thus verifying a role of methylation in its silencing and, moreover, 5-azacytidine treatment also re-sensitized MCF-7-TAM cells to tamoxifen, as evaluated by assays for viability, apoptosis and migration potential. [Sci Rep] Full Article Bullet shaped ellipsoidal nanostructures of size 600 ± 11.3 nm and 281.9 ± 5.3 nm with 2.2 aspect ratio were self-assembled using inorganic and organic GRAS biomaterials to preferentially target tumor-causing circulating tumor clusters. Negatively-charged chondroitin sulfate in presence of gelatin guides unidirectional growth of calcium carbonate mesocrystals to form nanobullets, mediatef CD44 targeting of CTCs. [Ann Biomed Eng] Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSMetabolic Crosstalk in the Breast Cancer Microenvironment The authors address current knowledge on this metabolic crosstalk within the breast tumor microenvironment (TME). Improved understanding of how metabolism in the TME modulates cancer development and evasion of tumor-suppressive mechanisms may provide clues for novel anticancer therapeutics directed to metabolic targets. [Eur J Cancer] Abstract The Regulatory Role of MicroRNAs in Breast Cancer Generally, miRNAs negatively regulate gene expression by binding to their selective messenger RNAs, thereby leading to either mRNA degradation or translational repression, depending on the degree of complementarity with target mRNA sequences. Aberrant expression of these miRNAs has been linked etiologically with various human diseases including breast cancer. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSInsilico Signs $200M AI Drug Discovery Partnership with China’s CTFH Shortly after publishing a paper demonstrating how its artificial intelligence programs could generate viable lead compounds in just a few weeks, Insilico Medicine has signed a dual-program discovery collaboration with Jiangsu Chia Tai Fenghai Pharmaceutical worth up to $200 million. Focused on previously undruggable targets in triple-negative breast cancer, the deal includes an upfront payment along with potential milestones and sales-based royalties pegged to any eventual products. [Questex LLC.] Editorial Seattle Genetics, Inc. announced dosing of the first patient in HER2CLIMB-02, a randomized Phase III clinical trial evaluating investigational agent tucatinib versus placebo, in combination with standard-of-care ado-trastuzumab emtansine, for patients with locally advanced or metastatic HER2-positive breast cancer. This trial is intended to support registration in the US Tucatinib is an oral, small molecule tyrosine kinase inhibitor that is highly selective for HER2. [Seattle Genetics, Inc.] Press Release BriaCell Therapeutics Corp. announced that it has initiated dosing in a Phase I/IIa clinical study of its lead product candidate, Bria-IMT™, in combination with Incyte’s INCMGA00012 and epacadostat in patients with advanced breast cancer whose disease has progressed following standard of care therapies. [BriaCell Therapeutics Corp.] Press Release Quanterix Announces Recipients of Annual Accelerator Grant Program Quanterix Corporation announced Shelli Kesler, Ph.D., and Ashley Henneghan, PhD., MSN, from the School of Nursing at the University of Texas at Austin, as the winners of its annual Accelerator Grant Program for their research proposal, “Neurodegenerative and Inflammatory Predictors of Cancer Related Cognitive Impairment in Breast Cancer Patients.” [Quanterix Corporation] Press Release | |
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EVENTSNEW Tumor Immunology and Immunotherapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant – Breast and Endocrine Tumors (University of Texas MD Anderson Cancer Center) Chief Editor – Nature Ageing (Nature Research) Postdoctoral Position – Cancer Biology (Memorial Sloan Kettering Cancer Center) Research Scientist – Breast Cancer (The University of Pittsburgh) Postdoctoral Researcher – Nanomedicine and Immunoengineering (University of California San Diego) Project Scientist – Breast and Hematological Tumors (Cedars-Sinai) Postdoctoral Fellow – Breast and Prostate Cancer (Mayo Clinic Comprehensive Cancer Center) Research Assistant – Endocrinology in Breast Cancer and Diabetes (Northwell Health) Postdoctoral Associate – Immune Responses (The Jackson Laboratory) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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