Mammary Cell News 11.46 November 28, 2019 | |
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TOP STORYDeregulating MYC in a Model of HER2+ Breast Cancer Mimics Human Intertumoral Heterogeneity Scientists investigated the role of c-MYC (MYC) in HER2+ disease, examining the relationship between HER2 expression and MYC phosphorylation in HER2+ patient tumors and characterizing the functional effects of deregulating MYC expression in the murine NeuNT model of amplified-HER2 breast cancer. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Functional Analysis of Genetic Variants in the High-Risk Breast Cancer Susceptibility Gene PALB2 Investigators describe the development of a relatively fast and easy cDNA-based system for the semi high-throughput functional analysis of 48 variants of uncertain significance in human PALB2. [Nat Commun] Full Article Micropeptide CIP2A-BP Encoded by LINC00665 Inhibits Triple-Negative Breast Cancer Progression Using triple-negative breast cancer cell lines, researchers showed that TGF-β-activated Smad signaling pathway induced the expression of translation inhibitory protein 4E-BP1, which inhibited eukaryote translation initiation factor elF4E, leading to reduced translation of CIP2A-BP from LINC00665. [EMBO J] Abstract | Graphical Abstract Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis The authors defined which members of the splicing factor SR and SR-like families contributed to breast cancer and uncovered differences and redundancies in their targets and biological functions. They identified splicing factors frequently altered in human breast tumors and assayed their oncogenic functions using breast organoid models. [Cell Rep] Full Article | Graphical Abstract Initiation of Human Mammary Cell Tumorigenesis by Mutant KRAS Requires YAP Inactivation Scientists designed experiments that exploited the ability of KRASG12D-transduced subsets of freshly isolated normal human mammary cells to form invasive tumors rapidly and efficiently when transplanted into immunodeficient mice. [Oncogene] Full Article FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer FoxO3a involvement in the acquisition and reversion of tamoxifen resistance was assessed in vitro in three parental ER+ breast cancer cells in the deriving tamoxifen resistant models (TamR) and in Tet-inducible TamR/FoxO3a stable cell lines. [Cancers] Full Article Targeting Triple Negative Breast Cancer Cells with Novel Cytotoxic Peptide-Doxorubicin Conjugates Researchers designed and synthesized two novel peptide-drug conjugates where the drug, doxorubicin, was linked to the peptide via a succinimidyl thioether bond or a hydrazone linker. [Bioconjug Chem] Abstract | Graphical Abstract The Landscape of Tiered Regulation of Breast Cancer Cell Metabolism Investigators systematically charted the different layers of metabolic regulation in breast cancer cells, predicting which enzymes and pathways were regulated at which level. They distinguished between two types of reactions, directly and indirectly regulated. [Sci Rep] Full Article Overexpressed mitogen-activated protein kinase kinase 4 (MAP2K4) in breast cancer cells increased proliferation, migration, and invasion in vivo and in vitro, while MAP2K4 knockdown restored the effects. [Aging (Albany NY)] Full Article The authors examined PI3K signaling upon CYH33 treatment in both resistant and parental cells. CYH33 suppressed the phosphorylation level of the PI3K downstream effector Akt in both resistant and parental cells in a dose-dependent manner. [Signal Transduct Target Ther] Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSDistinct Functions of AKT Isoforms in Breast Cancer: A Comprehensive Review Scientists aimed to give a comprehensive overview about the isoform-specific effects of protein kinase B (AKT) in breast cancer and to summarize known downstream and upstream mechanisms. [Cell Commun Signal] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSCDC Funds New Breast Cancer Survivorship Research at UIC With $1.8 million in funding from the US Centers for Disease Control and Prevention, the University of Illinois at Chicago will help young breast cancer survivors navigate post-treatment care and survival. [The University of Illinois at Chicago] Press Release Local Cancer Research Projects Receive Funding The Windsor Cancer Center Foundation handed out $200,000 to five recipients who are doing cancer research ranging from esophageal tumors, new therapy treatment for multiple myeloma, the immune system response to viruses in bone marrow transplants for patients with leukemia, inoperable glioblastoma tumors and studying cancer patients who want to continue to work. [Windsor Cancer Centre Foundation (iHeartRadio)] Press Release | |
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POLICY NEWSStark Party Differences in ‘Brexit Election’ Could Shape Future of UK Science When representatives of each party took to a stage last week at the Royal Society in London, they all promised increased funding and easier immigration for scientists. But Brexit loomed over the discussion, says Sarah Main, director of the Campaign for Science and Engineering, an advocacy group in London. [ScienceInsider] Editorial PhD Students in China Report Misery and Hope In a Nature survey, only 55 percent of the Chinese students who responded to the survey said that they were at least partially satisfied with their PhD experience. For the 5,630 respondents outside China, the satisfaction rate was 72 percent. [Nature News] Editorial Chinese Ministry Investigates Duplications in Papers by University President The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial
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EVENTSNEW Advances in Liquid Biopsies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Molecular Mechanisms in Cancers (Cleveland Clinic) Associate Faculty Member – Breast and Ovarian Cancer (Fred Hutchinson Cancer Research Center) Bioscience Leader – In Vitro Pharmacology in Oncology (AstraZeneca) Junior Group Leader – Bioinformatics in Translational Cancer Research (Mildred Scheel Career Center) Senior/Research Associate – In Vivo Pharmacology for Oncology Research (Moderna) Postdoctoral Fellow – Breast Cancer Stem Cells (Dalhousie University) Research Scholar – Breast Cancer (Eastern Virginia Medical School) Postdoctoral Scholar – Breast Cancer (The University of Kentucky) Postdoctoral Researcher – Breast and Ovarian Cancer (Curtin University) Postdoctoral Associate – Immune Responses (The Jackson Laboratory) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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