Mammary Cell News Volume 11.48 | Dec 12 2019

TOP STORY

CCR2 Signaling in Breast Carcinoma Cells Promotes Tumor Growth and Invasion by Promoting CCL2 and Suppressing CD154 Effects on the Angiogenic and Immune Microenvironments

Selective targeting of CCR2 in the PyVmT mammary epithelium inhibited tumor growth and invasion, elevated CD8⁺ T cells, decreased M2 macrophages and decreased angiogenesis. Co-culture models demonstrated these stromal cell responses were mediated by tumor-derived CCL2 and CCR2-mediated suppression of the T-cell activating cytokine, CD154. [Oncogene] Abstract

(Ranked by impact factor of the journal)

A Novel MetadherinΔ7 Splice Variant Enhances Triple Negative Breast Cancer Aggressiveness by Modulating Mitochondrial Function via NFĸB-SIRT3 Axis

Scientists identified a novel splice variant of metadherin with exon7 skipping (MTDHΔ7) and its levels were found to be significantly high in triple negative breast cancer (TNBC) cells and in patients diagnosed with TNBC. [Oncogene] Abstract

Intramitochondrial Src Kinase Links Mitochondrial Dysfunctions and Aggressiveness of Breast Cancer Cells

Investigators determined whether intra-mitochondrial Src (mtSrc) kinase had specific impact on breast cancer cells. They observed that activity of mtSrc was higher in breast cancer cells of the triple negative subtype. [Cell Death Dis] Full Article

miR-137 Alleviates Doxorubicin Resistance in Breast Cancer through Inhibition of Epithelial-Mesenchymal Transition by Targeting DUSP4

The authors demonstrated that miR-137 exerted a significant effect on repressing the development of chemoresistance of breast cancer cells in response to doxorubicin via attenuating epithelial-mesenchymal transition of tumor cells in vitro and in vivo. [Cell Death Dis] Full Article

Transcriptomic Analysis of Human Primary Breast Cancer Identifies Fatty Acid Oxidation as a Target for Metformin

In vitro assays showed that, in contrast to previous studies in models of normal cells, metformin reduced fatty acid oxidation with a subsequent accumulation of intracellular triglyceride, independent of AMPK activation. [Br J Cancer] Full Article

Aconitase 2 Inhibits the Proliferation of MCF-7 Cells Promoting Mitochondrial Oxidative Metabolism and ROS/FoxO1-Mediated Autophagic Response

Researchers showed that aconitase 2 levels were decreased in breast cancer cell lines and human tumour biopsies. They generated ACO2- overexpressing MCF-7 cells and employed comparative analyses to identify metabolic adaptations. [Br J Cancer] Abstract

LncRNA MACC1-AS1 Sponges Multiple miRNAs and RNA-Binding Protein PTBP1

Scientists report that MACC1-AS1, a cognate antisense long noncoding RNA of the sixth intron of the MACC1 gene, functioned as a cell growth modulator and enhanced breast tumor progress. [Oncogenesis] Full Article

Sodium Channel Na_v1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1

Researchers showed that reducing the expression of voltage-gated sodium channel (Na_V)1.5 in highly aggressive human MDA-MB-231 breast cancer cells reverted the mesenchymal phenotype, reduced cancer cell invasiveness and the expression of the epithelial-to-mesenchymal transition-promoting transcription factor SNAI1. [Sci Rep] Full Article

Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells

Investigators showed that lower doses of thioridazine targeted the self-renewal of basal-like breast cancer cells, but not breast cancer cells of other subtypes. [Sci Rep] Full Article

Novel Function of ∆Np63 in Cell Polarity and Metabolism in Pubertal Mammary Gland Development

The authors demonstrated that deletion of ∆Np63 at puberty resulted in depletion of mammary stem cell-enriched basal cells, reduced expression of E-cadherin and β-catenin, and led to a closed ductal lumen. [FEBS Lett] Abstract

Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News.

Transient Receptor Potential Cation Channel Subfamily V and Breast Cancer

Scientists provided an overview of transient receptor potential cation channel subfamily V (TRPV) expression in breast cancer subtypes, the roles of TRPV channels in various aspects of breast cancer progression and consider implications for future therapeutic approaches. [Lab Invest] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

NeuClone Announces Positive Results from Phase I Study of Herceptin^® (Trastuzumab) Biosimilar Candidate

NeuClone Pharmaceuticals Ltd announced that NeuCeptin, a biosimilar candidate of Herceptin^®, has successfully met all primary and secondary endpoints in a Phase I clinical trial. [NeuClone Pharmaceuticals Ltd] Press Release

NCCN Announces Projects Funded for Metastatic Breast Cancer Grant Program, in Collaboration with Pfizer

The National Comprehensive Cancer Network^® Oncology Research Program announced the proposals that were selected to receive funding, in collaboration with Pfizer Global Medical Grants, to improve the quality of care and outcomes for people with metastatic breast cancer. [The National Comprehensive Cancer Network] Press Release

KU Leuven Investigates Whether Stem Cell Scientist Falsified Data

KU Leuven is investigating allegations that one of its researchers, acclaimed stem cell biologist Catherine Verfaillie, was involved in falsifying research in at least 10 scientific papers published between 1999 and 2018, Belgian newspaper De Tijd reported last week. [The Scientist] Editorial

Congress Set to Form Groups to Protect US Research Security

Congress is expected to approve an annual defense bill as early as this week that would create two federal bodies aimed at preventing foreign government influence in scientific research. [The Scientist] Editorial

US Scientists Who Hide Foreign Ties Should Face Research Misconduct Sanctions, Panel Says

US scientists who violate government rules on disclosing foreign research ties should be investigated for research misconduct, says an independent group of prominent scientists asked to examine the threat of foreign influences on the US research enterprise. [ScienceInsider] Editorial

NEW 4^th DNA Repair/Replication Structures and Cancer Conference
February 16-20, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Leader – Breast Cancer Program (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Training Fellow – Molecular Oncology (Institute of Cancer Research)

NEW Postdoctoral Position – Fibroblasts in Breast Cancer (Institut Curie)

Assistant Professor – The Department of Breast Medical Oncology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Molecular Mechanisms in Cancers (Cleveland Clinic)

Junior Group Leader – Bioinformatics in Translational Cancer Research (Mildred Scheel Career Center)

Senior/Research Associate – In Vivo Pharmacology for Oncology Research (Moderna)

Postdoctoral Fellow – Breast Cancer Stem Cells (Dalhousie University)

Research Scholar – Breast Cancer (Eastern Virginia Medical School)

Postdoctoral Scholar – Breast Cancer (The University of Kentucky)

Postdoctoral Researcher – Breast and Ovarian Cancer (Curtin University)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Mammary Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.