Mammary Cell News Volume 12.00 | Jan 09 2020

TOP STORY

ULK1 Phosphorylates Exo70 to Suppress Breast Cancer Metastasis

Scientists report that ULK1 suppressed the migration and invasion of human breast cancer cells. The suppressive effect was mediated through direct phosphorylation of Exo70, a key component of the exocyst complex. [Nat Commun] Abstract

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Perturbation of Base Excision Repair Sensitizes Breast Cancer Cells to APOBEC3 Deaminase-Mediated Mutations

Researchers showed that elevated expression of the bifunctional DNA glycosylase, NEIL2, sensitized breast cancer cells to APOBEC3B-mediated mutations and double strand breaks by perturbing canonical base excision repair. [eLife] Abstract

LINC00665 Promotes Breast Cancer Progression through Regulation of the miR-379-5p/LIN28B Axis

The authors demonstrated that LINC00665 promoted breast cancer cell proliferation, migration, and invasion. Accumulating evidence indicated that many lncRNAs could function as endogenous miRNA sponges by competitively binding common miRNAs. [Cell Death Dis] Full Article

UBE2O Promotes the Proliferation, EMT and Stemness Properties of Breast Cancer Cells through the UBE2O/AMPKα2/mTORC1-MYC Positive Feedback Loop

In vitro assays revealed that ubiquitin-conjugating enzyme E2O (UBE2O) promoted breast cancer cell proliferation and epithelial-mesenchymal transformation and endowed breast cancer cells with cancer stemness properties. [Cell Death Dis] Full Article

N-Glycosylated SGK196 Suppresses the Metastasis of Basal-Like Breast Cancer Cells

Investigators demonstrated that SGK196 was primarily modified by N-glycosylation in breast cancer cells. Furthermore, gain and loss-of-function studies showed that N-glycosylated SGK196 suppressed cell migration, invasion, and metastasis in breast cancer. [Oncogenesis] Full Article

Suppressing the Metastatic Properties of the Breast Cancer Cells Using STAT3 Decoy Oligodeoxynucleotides: A Promising Approach for Eradication of Cancer Cells by Differentiation Therapy

Signal transducer and activator of transcription 3 (STAT3) decoy oligodeoxynucleotides treatment showed cell growth inhibition by decreasing cell viability, increasing the percentage of arrested cells in G0/G1 phases, and triggering apoptosis. [J Cell Physiol] Abstract

Down-Regulation of Long Non-Coding RNA HOTAIR Sensitizes Breast Cancer to Trastuzumab

Trastuzumab-resistant breast cancer cell line SK-BR-3-TR was assayed for the expression of HOX antisense intergenic RNA, epithelial-mesenchymal transition-related proteins or genes. [Sci Rep] Full Article

Up-Regulated Fibronectin in 3D Culture Facilitates Spreading of Triple Negative Breast Cancer Cells on 2D through Integrin β-5 and Src

Researchers found that the mRNA and protein levels of fibronectin were increased in MDA-MB-231 cells and its lung metastatic derivative, when cultivated in three-dimensional suspension cultures. [Sci Rep] Full Article

LncRNA RP11-19E11 Is an E2F1 Target Required for Proliferation and Survival of Basal Breast Cancer

Scientists evaluated the function of a subset of long non-coding RNA (lncRNA) candidates in the oncogenic process in vitro. They report the identification and characterization of the chromatin-associated lncRNA, RP11-19E11.1, which was upregulated in 40% of basal primary breast cancers. [npj Breast Cancer] Full Article

Mutant P53 Induces MELK Expression by Release of Wild-Type P53-Dependent Suppression of FOXM1

The authors determined the molecular mechanism by which maternal embryonic leucine zipper kinase (MELK) was overexpressed in triple-negative breast cancer. MELK protein levels were higher in p53-mutant versus p53 wild-type breast cancer cells. [npj Breast Cancer] Full Article

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Role of Sensory Neurons, Neuroimmune Pathways, and Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in a Murine Model of Breast Cancer Metastasis

Inactivation of sensory neurons either with high-dose capsaicin treatment or local ablation of vagal sensory nerve activity markedly increases metastasis of breast carcinoma formed by 4T1 derivative cells. [Cancer Immunol Immunother] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Veracyte Announces Biopharmaceutical Collaboration with Acerta Pharma

Veracyte, Inc. announced a multi-year partnership with Acerta Pharma, the hematology research and development arm of AstraZeneca, to provide genomic information that will support the biopharmaceutical company’s development of oncology therapeutics. [Veracyte, Inc.] Press Release

Oxford BioTherapeutics Initiates Dose-Escalation Portion of US Phase I Clinical Trial for OBT076 in Patients with Advanced Solid Tumors

Oxford BioTherapeutics Ltd. announced the initiation of the dose-escalation portion of its US Phase I program for OBT076, a CD205 targeting antibody-drug conjugate, in patients with advanced solid tumors. [Oxford BioTherapeutics Ltd.] Press Release

UK Group Tackles Reproducibility in Research

Last month, ten UK universities became part of the UK Reproducibility Network, joining a network that already includes stakeholders such as the Academy of Medical Sciences, Research Libraries UK, the National Institute for Biological Standards and Control, journals including Nature and PLOS, and local networks of researchers. [The Scientist] Editorial

Scripps Acquires Pfizer’s Massive Microbial Library

The East Coast campus of the research institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products. [The Scientist] Editorial

NEW 2^nd Nuclear Receptors Conference
February 24-27, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Breast Cancer Immunology and Immunotherapy (The University of Texas)

NEW Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute)

NEW Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina)

NEW Postdoctoral Fellow – Brain Metastasis in Aggressive Breast Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Scientist – Metabolism and Epigenetics in Breast Cancer (The Cancer Research UK Beatson Institute)

Postdoctoral Training Fellow – Breast Cancer Research (Institute of Cancer Research)

Leader – Breast Cancer Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Training Fellow – Molecular Oncology (Institute of Cancer Research)

Postdoctoral Position – Fibroblasts in Breast Cancer (Institut Curie)

Assistant Professor – The Department of Breast Medical Oncology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Molecular Mechanisms in Cancers (Cleveland Clinic)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

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