Mammary Cell News Volume 12.01 | Jan 16 2020

TOP STORY

ARID1A Determines Luminal Identity and Therapeutic Response in Estrogen-Receptor-Positive Breast Cancer

ARID1A inactivation in cells and in patients led to resistance to estrogen-receptor degraders by facilitating a switch from estrogen-receptor-dependent luminal cells to estrogen-receptor-independent basal-like cells. [Nat Genet] Abstract

(Ranked by impact factor of the journal)

STING-Dependent Paracriny Shapes Apoptotic Priming of Breast Tumors in Response to Anti-Mitotic Treatment

Scientists showed that a proapoptotic secretory phenotype was induced by activation of cGAS/STING in cancer cells that were hit by antimitotic treatment, accumulated micronuclei and maintained mitochondrial integrity despite intrinsic apoptotic pressure. [Nat Commun] Full Article

Macrophages Induce Malignant Traits in Mammary Epithelium via IKKε/TBK1 Kinases and the Serine Biosynthesis Pathway

Researchers demonstrated that breast epithelial cells acquired malignant properties when exposed to medium conditioned by macrophages derived from human healthy donors. These effects were mediated by the breast cancer oncogene IKKε and its downstream target, the serine biosynthesis pathway. [EMBO Mol Med] Full Article | Graphical Abstract

Downregulation of Circulating miR 802-5p and miR 194-5p and Upregulation of Brain MEF2C along Breast Cancer Brain Metastasization

Breast cancer cells were injected in the carotid artery of mice to preferentially induce metastasis in the brain, and samples were collected at different time points to follow metastasis development. [Mol Oncol] Abstract | Full Article

miRNAs as Radio-Response Biomarkers for Breast Cancer Stem Cells

Exposition of breast cancer cells to radiation doses affected their phenotype, functional characteristics, pluripotency gene expression, and in vivo tumorigenic capacity. [Mol Oncol] Abstract | Full Article

APOBEC3B Expression in Breast Cancer Cell Lines and Tumors Depends on the Estrogen Receptor Status

The authors measured the expression of APOBEC3A and APOBEC3B genes in two breast cancer cell lines treated with estradiol, cisplatin, or their combination. [Carcinogenesis] Full Article

Comparative Membrane N-Glycomics of Different Breast Cancer Cell Lines to Understand Breast Cancer Brain Metastasis

Liquid chromatography-tandem mass spectrometry was employed to analyze enriched membrane N-glycomes from five breast cancer cell lines and one brain cancer cell line. [J Proteome Res] Abstract | Graphical Abstract

Exosomes Released upon Mitochondrial ASncmtRNA Knockdown Reduce Tumorigenic Properties of Malignant Breast Cancer Cells

Scientists report that exosomes derived from antisense oligonucleotide (ASO-1537S)-treated MDA-MB-231 breast cancer cells inhibited tumorigenesis of recipient cells, in contrast to exosomes derived from control-ASO-treated cells which, in contrast, enhanced these properties. [Sci Rep] Full Article

BAD Sensitizes Breast Cancer Cells to Docetaxel with Increased Mitotic Arrest and Necroptosis

Researchers showed that docetaxel therapy preferentially reduced growth of Bcl-2-associated death promoter (BAD)-expressing xenograft tumors. They explored the cellular mechanism whereby BAD sensitized cells to docetaxel. [Sci Rep] Full Article

SAG Expression Associates with COPB2-Related Signaling and a Poorer Prognosis in Breast Cancer

Investigators revealed that SAG gene expression was upregulated in breast cancer cells and that SAG overexpression was associated with significant poorer survival in breast cancer, especially the luminal A subtype. [Aging (Albany NY)] Full Article

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Breast Cancer Stem Cell Antigens as Targets for Immunotherapy

The authors summarize the controversial nature of breast cancer stem cells, discuss why they represent good candidates for cancer immunotherapy, and review the cancer stem cell antigens that have been used as targets for cancer stem cell immunotargeting. [Semin Immunol] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Quantum Leap Healthcare Collaborative and G1 Therapeutics Announce the Selection of Trilaciclib in the I-SPY 2 TRIAL for Breast Cancer

Quantum Leap Healthcare Collaborative^™ and G1 Therapeutics, Inc. announced a collaboration to evaluate trilaciclib in a new randomized, investigational treatment arm for the ongoing I-SPY 2 TRIAL^™ for neoadjuvant treatment of locally advanced breast cancer. [G1 Therapeutics, Inc.] Press Release

Zymeworks Announces Agreement with Pfizer and Initiation of a New Phase II Trial Evaluating ZW25 in Combination with Ibrance^® (Palbociclib)

Zymeworks Inc. announced the initiation of a Phase II trial evaluating ZW25 combination therapy and an agreement with Pfizer which advances the study. Zymeworks’ HER2-targeted bispecific antibody ZW25 is being evaluated in combination with Pfizer’s Ibrance^®, an oral CDK4/6 inhibitor. [Zymeworks, Inc.] Press Release

Florida Cracks Down on Foreign Government Involvement in Research

Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial

NEW 2^nd Epigenetics Conference
February 28-March 2, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – DNA Nanotechonology in Cancer (University of Duisburg-Essen)

NEW Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Fellowship – Breast Cancer Immunology and Immunotherapy (The University of Texas Southwestern)

Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina)

Postdoctoral Fellow – Brain Metastasis in Aggressive Breast Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Scientist – Metabolism and Epigenetics in Breast Cancer (The Cancer Research UK Beatson Institute)

Leader – Breast Cancer Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Fibroblasts in Breast Cancer (Institut Curie)

Assistant Professor – The Department of Breast Medical Oncology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Molecular Mechanisms in Cancers (Cleveland Clinic)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

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