Mammary Cell News Volume 12.02 | Jan 23 2020

TOP STORY

The Single-Cell Pathology Landscape of Breast Cancer

Single-cell analysis identified the phenotypes of tumor and stromal single cells, their organization and their heterogeneity, and enabled the cellular architecture of breast cancer tissue to be characterized on the basis of cellular composition and tissue organization. [Nature] Abstract

(Ranked by impact factor of the journal)

Cancer-Associated Fibroblast Heterogeneity in Axillary Lymph Nodes Drives Metastases in Breast Cancer through Complementary Mechanisms

Two myofibroblastic subsets, cancer-associated fibroblast (CAF)-S1 and CAF-S4, accumulated in lymph nodes and correlated with cancer cell invasion. By developing functional assays on primary cultures, scientists demonstrated that these subsets promoted metastasis through distinct functions. [Nat Commun] Full Article

Epigenetic Reprogramming at Estrogen-Receptor Binding Sites Alters 3D Chromatin Landscape in Endocrine-Resistant Breast Cancer

Investigators showed that three-dimensional chromatin interactions both within and between topologically associating domains frequently changed in estrogen-receptor⁺ endocrine-resistant breast cancer cells and that the differential interactions were enriched for resistance-associated genetic variants at CTCF-bound anchors. [Nat Commun] Full Article

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

Scientists tested the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modified the expression of oncogenes, or genes encoding transcription factors, cell division, and cell proliferation in MCF7 cells, a human breast cancer cell line. [Front Oncol] Full Article

Exosome-Transmitted miR-567 Reverses Trastuzumab Resistance by Inhibiting ATG5 in Breast Cancer

A series of gain- or loss-functional assays were performed to define the function of miR-567 and ATG5 in trastuzumab resistance and autophagy, both in vitro and in vivo. [Cell Death Dis] Full Article

MYC Regulates Fatty Acid Metabolism through a Multigenic Program in Claudin-Low Triple Negative Breast Cancer

Researchers determined key roles for fatty acid transporters, lipases, and kinases that each contributed to promoting fatty acid oxidation in human mammary epithelial cells that expressed oncogenic levels of MYC. [Br J Cancer] Full Article

DOX-Loaded Peptide Dendritic Copolymer Nanoparticles for Combating Multidrug Resistance by Regulating the Lysosomal Pathway of Apoptosis in Breast Cancer Cells

In vitro, mPEGylated dendron-GFLG-DOX conjugate based nanoparticles could significantly promote cellular uptake and accumulation, potent cytotoxicity and apoptosis compared to free DOX in resistant cells. [J Mater Chem B] Abstract

RNA-Binding Protein CUGBP1 Controls the Differential INSR Splicing in Molecular Subtypes of Breast Cancer Cells and Affects Cell Aggressiveness

In breast cancer cell lines, the IR-A:IR-B ratio varied in different molecular subtypes, knockdown or overexpression of CUGBP1 gene in breast cancer cells altered IR-A:IR-B ratio through modulation of IR-A expression. [Carcinogenesis] Abstract

Investigating Chaperonin-Containing TCP-1 Subunit 2 as an Essential Component of the Chaperonin Complex for Tumorigenesis

Researchers investigated the activity of chaperonin-containing TCP-1 2 by overexpressing or depleting the subunit in breast epithelial and breast cancer cells. [Sci Rep] Full Article

Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1

Investigators evaluated the association of phosphorylated ribosomal S6 kinase 1 (p-S6K1) expression with radio-resistance in breast cancer cell lines and patients. [Sci Rep] Full Article

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Stable Isotopes for Tracing Mammalian-Cell Metabolism in Vivo

The authors review recent work where in vivo stable-isotope measurements have been used to address relevant biological questions within an in vivo context, summarize different experimental and data interpretation approaches and their limitations, and discuss future opportunities in the field. [Trends Biochem Sci] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

AXIM^® Biotechnologies Acquiree Sapphire Biotech, Inc. Signs License Agreement to Exclusively License Patent Rights in Cancer Technology

AXIM^® Biotechnologies, Inc. announced that its acquiree Sapphire Biotech, Inc. has signed an agreement with Skysong Innovations, LLC to exclusively license rights to pharmaceutical compositions and methods for the treatment of cancer. [AXIM^® Biotechnologies, Inc.] Press Release

METAvivor Announces 2019 Grant Awards For Metastatic Breast Cancer Research

METAvivor Research and Support, Inc. announces 32 grant awards totaling $5,000,000. These research grants will enhance the understanding of metastatic breast cancer, help improve current treatments and develop greatly needed therapeutic options to combat this complicated disease. [METAvivor Research and Support, Inc. (Vocus PRW Holdings, LLC)] Press Release

Impressive Results Continue from CytoDyn’s Clinical Trials Evaluating Two Patients with Leronlimab, One in mTNBC and One in MBC

CytoDyn, Inc. announced additional promising results from its clinical trials evaluating leronlimab for the treatment of metastatic triple-negative breast cancer and metastatic breast cancer (MBC). [CytoDyn, Inc.] Press Release

Campus Attacks by Nationalists and Police Alarm India’s Scientific Community

The attack on one of India’s most prestigious universities sent shock waves around the country and is the latest sign that the political forces tearing apart Indian society are also affecting the country’s academic community. Students at JNU, a liberal bastion, had been on strike for months against both a major hike in student fees and the government’s controversial Citizenship Amendment Act, widely decried as discriminatory against Muslims. [ScienceInsider] Editorial

Moffitt Cancer Center Details Links of Fired Scientists to Chinese Talent Programs

Six Florida cancer researchers who were dismissed last month for hiding their ties to a Chinese medical university appear to have been motivated by simple greed and a disregard for both institutional and federal rules. [ScienceInsider] Editorial

NEW American Association for Cancer Research (AACR) Meeting: The Evolving Landscape of Cancer Modeling
March 2-5, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Research Fellow – Anti-Cancer Therapy (Mayo Clinic)

Postdoctoral Position – DNA Nanotechonology in Cancer (University of Duisburg-Essen)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Fellowship – Breast Cancer Immunology and Immunotherapy (The University of Texas Southwestern)

Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina)

Postdoctoral Fellow – Brain Metastasis in Aggressive Breast Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Scientist – Metabolism and Epigenetics in Breast Cancer (The Cancer Research UK Beatson Institute)

Leader – Breast Cancer Program (Fred Hutchinson Cancer Research Center)

Assistant Professor – The Department of Breast Medical Oncology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Molecular Mechanisms in Cancers (Cleveland Clinic)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

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