Mammary Cell News Volume 12.04 | Feb 06 2020

TOP STORY

Inhibition of Notch1 Reverses EMT and Chemoresistance to Cisplatin via Direct Down-Regulation of MCAM in Triple-Negative Breast Cancer Cells

Notch1 promoted epithelial-mesenchymal transition (EMT) and chemoresistance, as well as invasion and proliferation of triple-negative breast cancer cells via direct activating melanoma cell adhesion molecule (MCAM) promoter. [Int J Cancer] Abstract

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A Role for CBFβ in Maintaining the Metastatic Phenotype of Breast Cancer Cells

Scientists established through cytokeratin 5 (CK5) knockout and overexpression in ER⁺ breast cancer cell lines that CK5 was important for tumorsphere formation, prompting them to speculate that CK5 had regulatory activity in cancer stem cells. [Oncogene] Abstract

Aurora B Induces Epithelial-Mesenchymal Transition by Stabilizing Snail1 to Promote Basal-Like Breast Cancer Metastasis

Researchers showed that elevated Aurora B expression in breast cancer cells activated AKT/GSK3β to stabilize Snail1 protein, a master regulator of epithelial-mesenchymal transition (EMT), leading to EMT induction in a kinase-dependent manner. [Oncogene] Abstract

Targeting the EphB4 Receptor Tyrosine Kinase Sensitizes HER2-Positive Breast Cancer Cells to Lapatinib

Investigators showed that EphB4 overexpression conferred gain-of-function activities to HER2-positive breast cancer cells, rendering resistance to a HER2/EGFR inhibitor Lapatinib. [Cancer Lett] Full Article

Ibrutinib Treatment Inhibits Breast Cancer Progression and Metastasis by Inducing Conversion of Myeloid-Derived Suppressor Cells to Dendritic Cells

Ibrutinib inhibited proliferation of cancer cells in vitro, and ibrutinib-treated mice displayed significantly lower tumor burdens and metastasis compared to controls. [Br J Cancer] Abstract

Estrone Decorated Poly-Ion Complex Micelles for Targeted Melittin Delivery to Hormone Responsive Breast Cancer Cells

The authors developed estrone appended poly-ion complex micelle to deliver melittin, a cytotoxic peptide, to breast cancer cells. Amino functionalization of estrone was performed to conjugate estrone to the di-block polymer synthesized by RAFT polymerization. [Biomacromolecules] Abstract

The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates the ABCB1-Mediated Adriamycin Resistance of Breast Cancer via Wnt/β-Catenin Signal Pathway

Researchers identified a panel of differentially expressed lncRNAs, mRNAs and miRNAs in MCF-7 and MCF-7/adriamycin cell lines through RNA-seq technologies. Growth arrest-specific 5 (GAS5) level was down-regulated whereas ABCB1 level was up-regulated in the resistant breast cancer tissues and cells. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract

Cryoablation-Activated Enhanced Nanodoxorubicin Release for the Therapy of Chemoresistant Mammary Cancer Stem-Like Cells

Scientists demonstrated that temperature-negative expansion nanodrugs could achieve the controllable and enhanced release of anticancer drugs when combined with cryoablation and effectively overcome chemoresistance in mammary cancer stem-like cells. [J Mater Chem B] Abstract

The Expression of the Long NEAT1_2 Isoform Is Associated with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers

Investigators report that NEAT1_2 expression correlates with HER2-positive breast cancers and high-grade disease. They provided evidence that NEAT1_1 and NEAT1_2 have distinct expression pattern among different intrinsic breast cancer subtypes. [Sci Rep] Full Article

Estradiol/GPER Affects the Integrity of Mammary Duct-Like Structures In Vitro

Researchers used 3D-cultured MCF-10A acini as a breast duct model and demonstrated various deleterious effects of 17-β estradiol, including the destruction of the basement membrane surrounding the acini, abnormal adhesion between cells, and cell death via apoptosis and pyroptosis. [Sci Rep] Full Article

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TP53 Mutations and Outcomes in Breast Cancer: Reading beyond the Headlines

The authors discuss studies that have assessed the role of TP53 mutations in breast cancer treatment and limitations in interpreting reported results. [Trends Cancer] Abstract

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EMA Validates Seattle Genetics’ Marketing Authorization Application for Tucatinib for Patients with Locally Advanced or Metastatic HER2-Positive Breast Cancer

Seattle Genetics, Inc. announced that the European Medicines Agency validated the Marketing Authorization Application for tucatinib, in combination with trastuzumab and capecitabine, for the treatment of adult patients with locally advanced unresectable or metastatic HER2-positive breast cancer. [Seattle Genetics, Inc.] Press Release

CytoDyn Announces Stunning Results from Clinical Trials Evaluating mTNBC and MBC with Leronlimab and Will Request an Emergency Type C Meeting with FDA to Enroll 50 Awaiting Patients with a Serious Solid Tumor Cancer Condition

CytoDyn Inc. announced very strong data from patients in its clinical trials with metastatic triple-negative breast cancer (mTNBC) and metastatic breast cancer (MBC). [CytoDyn Inc.] Press Release

Ex-Emory Scientist with Ties to China Charged with Fraud

A former Emory University neuroscientist has been charged with defrauding the US government by taking a salary from a Chinese institution while also being paid through research grants from the National Institutes of Health. The charges against Li Xiao-Jiang were filed on 21 November 2019 in US district court in Atlanta and were first reported by NBC News. [ScienceInsider] Editorial

US Prosecutor Leading China Probe Explains Effort That Led to Charges against Harvard Chemist

The US government isn’t prosecuting Charles Lieber because he’s a world-renowned inorganic chemist at Harvard University, says the US attorney who last week drew headlines by charging Lieber with making false statements about his ties to Chinese research institutions. Nor does the Department of Justice think for one minute that Lieber is a spy. [ScienceInsider] Editorial

NEW Tracing the Cellular Processes Driving Mammary Gland Development and Breast Cancer
June 6-7, 2020
Lucca, Italy

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NEW Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

NEW Postdoctoral Researcher – Cancer Pathogenesis (National University of Ireland Galway)

Associate Director – Translational Science in Breast Cancer (AstraZeneca)

Postdoctoral Fellow – Breast Tumorigenesis (University of Cincinnati)

Research Fellow – Anti-Cancer Therapy (Mayo Clinic)

Postdoctoral Position – DNA Nanotechonology in Cancer (University of Duisburg-Essen)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Fellowship – Breast Cancer Immunology and Immunotherapy (The University of Texas Southwestern)

Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina)

Postdoctoral Fellow – Brain Metastasis in Aggressive Breast Cancers (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Scientist – Metabolism and Epigenetics in Breast Cancer (The Cancer Research UK Beatson Institute)

Leader – Breast Cancer Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

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