Mammary Cell News Volume 12.08 | Mar 5 2020

TOP STORY

Acetylation of MORC2 by NAT10 Regulates Cell-Cycle Checkpoint Control and Resistance to DNA-Damaging Chemotherapy and Radiotherapy in Breast Cancer

Researchers report a novel function for MORC family CW-type zinc finger 2 (MORC2) in cell-cycle checkpoint control through an acetylation-dependent mechanism. MORC2 was acetylated by the acetyltransferase NAT10 at lysine 767and this process was counteracted by the deacetylase SIRT2 under unperturbed conditions. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

Cyp2c44 Regulates Prostaglandin Synthesis, Lymphangiogenesis, and Metastasis in a Mouse Model of Breast Cancer

Investigators studied tumor growth and metastasis in Cyp2c44^−/− mice crossed onto the polyoma middle T oncogene (PyMT) background. The resulting PyMT^2c44 mice developed more primary tumors earlier than PyMT mice, with increased lymph and lung metastasis. [Proc Natl Acad Sci USA] Abstract

Capicua Restricts Cancer Stem Cell-Like Properties in Breast Cancer Cells

Capicua (CIC) deficiency critically enhanced cancer stem cell (CSC) self-renewal and multiple CSC subpopulations of breast cancer cells without altering their growth rate or invasiveness. [Oncogene] Abstract

An In Vitro Hyaluronic Acid Hydrogel Based Platform to Model Dormancy in Brain Metastatic Breast Cancer Cells

Investigators developed an in vitro hyaluronic acid (HA) hydrogel platform to model dormancy in brain metastatic breast cancer cells via exploiting the bio-physical cues provided by HA hydrogels while bracketing the normal brain and metastatic brain malignancy relevant stiffness range. [Acta Biomater] Abstract | Graphical Abstract

Anti-HER2 Antibody Therapy Using Gene-Transduced Adipocytes for HER2-Positive Breast Cancer

Researchers constructed gene-transduced human ceiling culture-derived proliferative adipocytes secreting anti-HER2 antibody and evaluated their ability to secrete antibodies and mediate an anti-tumor effect. [Breast Cancer Res Treat] Abstract

CtBP1 Transactivates RAD51 and Confers Cisplatin Resistance to Breast Cancer Cells

Immunohistochemistry revealed that RAD51 expression was positively correlated with C-terminal binding protein 1 (CtBP1) expression in breast cancer patient tissues; short hairpin RNA-mediated CtBP1 depletion, chromatin immunoprecipitation, and dual-luciferase reporter assays showed that CtBP1 activated RAD51 transcription in breast cancer cells. [Mol Carcinog] Abstract

Indirect Regulation of TFPI-2 Expression by miR-494 in Breast Cancer Cells

As miR-494 protects against breast cancer progression, researchers investigated whether miR-494 was involved in the regulation of TFPI-2 in MCF-7 breast cancer cells. [Sci Rep] Full Article

Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract

Investigators report the biological activities of A. hirsuta extract associated with the regulation of apoptosis and JNK and p38 in MCF-7 breast cancer cells. [Molecules] Abstract | Full Article Download

MicroRNA-124-3p.1 Promotes Cell Proliferation through Axin1-Dependent Wnt Signaling Pathway and Predicts a Poor Prognosis of Triple-Negative Breast Cancer

miR-124-3p.1 expression was elevated in advanced triple‐negative breast cancer (TNBC) patients, and high miR-124-3p.1 predicted poor overall survival in TNBC patients. Further data showed that miR-124-3p.1 downregulation diminished, while miR-124-3p.1 upregulation increased the growth of TNBC cells in vitro and in vivo. [J Clin Lab Anal] Full Article

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Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value

Investigators inspect the routes to metastasis and how they can be linked to specific features of circulating tumor cells (CTCs), how CTC analysis may be used in therapy, and what is the current status of the research and efforts to include CTC analysis in clinical practice. [Int J Mol Sci] Abstract | Full Article Download

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MPM Capital Announces $100M Oncology Innovations Fund as Part of Novel Venture Philanthropy Collaboration with Dana-Farber Cancer Institute

MPM Capital and Dana-Farber Cancer Institute have entered into a unique, first-of-its-kind, impact investing collaboration. The initiative partners fundraising for biotech venture capital investing with philanthropic fundraising for cancer research. [MPM Capital (Business Wire, Inc.)] Press Release

CytoDyn Reports Remarkable Outcomes for Additional Cancer Patients in mTNBC Trial; Following an Overwhelming Community Response, CytoDyn Expects to Enroll More Than 20 Patients in its 22 Solid Tumor Cancer Trial in the Next 60 Days

CytoDyn Inc. announced continued positive data for its metastatic triple-negative breast cancer (mTNBC) and metastatic breast cancer patients. [CytoDyn Inc.] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist]] Editorial

NEW Cambridge International Stem Cell Symposium 2020
September 27-29, 2020
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Investigator – Breast Cancer Cell Biology (Florida Atlantic University)

Research Assistant – 3D Models of Breast Cancer (University of Cambridge)

Postdoctoral Associate – Oncology (University of Miami Health System)

Postdoctoral Research Position – Breast Cancer Research (The University of Texas)

Postdoctoral Position – Breast Cancer Metastasis (University of Kentucky)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Fellow – Breast Tumorigenesis (University of Cincinnati)

Postdoctoral Position – DNA Nanotechonology in Cancer (University of Duisburg-Essen)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina)

Postdoctoral Fellow – Brain Metastasis in Aggressive Breast Cancers (The University of Texas MD Anderson Cancer Center)

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