Mammary Cell News Volume 12.11 | Mar 26 2020

TOP STORY

The Secreted Protease Adamts18 Links Hormone Action to Activation of the Mammary Stem Cell Niche

Researchers showed that estrogen and progesterone induced the secreted protease Adamts18 in myoepithelial cells by controling Wnt4 expression with consequent paracrine canonical Wnt signaling activation. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Metastasis-Initiating Cells Induce and Exploit a Fibroblast Niche to Fuel Malignant Colonization of the Lungs

Scientists showed that disseminated breast cancer cells evoked phenotypic changes in lung fibroblasts, forming a supportive metastatic niche. [Nat Commun] Full Article | Press Release

Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA-1-Proficient Breast Cancer to PARP Inhibition

Investigators found that the extinction of Pin1 decreased homologous recombination to the level of BRCA1-deficient cells. Pin1 stabilized BRCA1 by preventing ubiquitination of BRCA1 at Lys1037. [Cancer Res] Abstract

Metastatic Breast Cancer Cells Induce Altered Microglial Morphology and Electrical Excitability In Vivo

Scientists developed a model to study metastatic breast cancer cell-microglial interactions using intravital imaging combined with ex vivo electrophysiology. [J Neuroinflammation] Full Article

Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles

The authors presented a combination strategy of pretreatment of MDA-MB-231/MDR1 cells with quercetin followed by doxorubicin to overcome multidrug resistence, which can be delivered by mixed micelles composed of the reduction-sensitive hyaluronic acid-based conjugate and d-α-tocopheryl poly(ethylene glycol) 1000 succinate. [Mol Pharm] Abstract | Graphical Abstract

Folic Acid-Modified Nanoerythrocyte for Codelivery of Paclitaxel and Tariquidar to Overcome Breast Cancer Multidrug Resistance

Investigators prepared a folic acid-modified nanoerythrocyte system to simultaneously transport paclitaxel and tariquidar, and they evaluated in vitro and in vivo characteristics of this delivery system through several experiments [Mol Pharm] Abstract | Graphical Abstract

Regulation of Hippo Signaling and Triple Negative Breast Cancer Progression by an Ubiquitin Ligase RNF187

The authors determined RNF187 as a negative regulator for Hippo signaling activation. RNF187 depletion significantly decreased cell migration and invasion capacity in triple negative breast cancer. [Oncogenesis] Full Article

Time-Dependent Interactions of Blood Platelets and Cancer Cells, Accompanied by Extramedullary Hematopoiesis, Lead to Increased Platelet Activation and Reactivity in a Mouse Orthotopic Model of Breast Cancer – Implications for Pulmonary and Liver Metastasis

Scientists demonstrated that the age-associated progression of breast cancer cells was connected with increased platelet functioning, and that it could be manifested by the increased number of metastases and extramedullary hematopoiesis in a time-dependent-manner. [Aging (Albany NY)] Full Article

Novel Chemo-Photothermal Therapy in Breast Cancer Using Methotrexate-Loaded Folic Acid Conjugated AU@SiO₂ Nanoparticles

Researchers investigated the combined effect of folate/Methotrexate loaded silica coated gold nanoparticles and low level laser therapy in the fight against breast cancer. [Nanoscale Res Lett] Full Article

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The Implication of the SUMOylation Pathway in Breast Cancer Pathogenesis and Treatment

The authors describe the role of SUMOylation in breast tumorigenesis and its implication for breast cancer therapy. [Crit Rev Biochem Mol Biol] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Bolt Biotherapeutics Announces Initiation of BDC-1001 Clinical Trial in Patients with HER2-Expressed Solid Tumors

Bolt Biotherapeutics, Inc. announced that patient dosing has begun in the company’s Phase I, open-label, dose-escalation and dose expansion study of BDC-1001 monotherapy for patients with HER2-expressed solid tumors. [Bolt Biotherapeutics, Inc.] Press Release

ENHERTU^® Approved in Japan for Treatment of Patients with HER2 Positive Unresectable or Metastatic Breast Cancer

Daiichi Sankyo Company, Limited announced the approval of ENHERTU^®, a HER2 directed antibody drug conjugate, in Japan for the treatment of patients with HER2 positive unresectable or recurrent breast cancer after prior chemotherapy. [Daiichi Sankyo Company, Limited] Press Release

Researchers Are Tracking Another Epidemic, Too—of Misinformation

When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse.” Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information—some of it accurate, some not so much—that has saturated social and traditional media. [ScienceInsider] Editorial

After Conference Cancellations, Some Scientists Find a Way

As scores of academic meetings get upended due to COVID-19, researchers are turning to virtual replacements. [The Scientist] Editorial

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NEW Tenure Track Faculty Positions – Breast Cancer (Georgetown University Medical Center)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Position – Cancer Genomics and Epigenomics Research (NIH National Cancer Institute)

Postdoctoral Fellow – RAS Cancer Cell Biology (University of Luxembourg)

Group Leaders – Cancer Biology (Institute of Pharmacology and Structural Biology)

Postdoctoral Training Fellow – Endocrine Control Mechanisms (Institute of Cancer Research)

Postdoctoral Investigator – Breast Cancer Cell Biology (Florida Atlantic University)

Postdoctoral Research Position – Breast Cancer Research (The University of Texas)

Postdoctoral Position – Breast Cancer Metastasis (University of Kentucky)

Postdoctoral Fellow – Breast Tumorigenesis (University of Cincinnati)

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