Mammary Cell News Volume 12.12 | Apr 2 2020

TOP STORY

Differential Regulation of Breast Cancer Bone Metastasis by PARP1 and PARP2

Researchers showed that olaparib increased breast cancer bone metastasis through poly[ADP-ribose]polymerase 2 (PARP2), but not PARP1, specifically in the myeloid lineage, but not in the cancer cells. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Integrative Analysis of Genomic Amplification-Dependent Expression and Loss-Of-Function Screen Identifies ASAP1 as a Driver Gene in Triple-Negative Breast Cancer Progression

Scientists applied Analytical Multi-scale Identification of Recurring Events analysis and transcript quantification in the triple-negative breast cancer genome across 222 triple-negative breast cancer tumors and identified 138 candidate genes with positive correlation in copy number gain and gene expression. [Oncogene] Full Article

Therapeutic Delivery of Polymeric Tadpole Nanostructures with High Selectivity to Triple Negative Breast Cancer Cells

Investigators showed, in the absence of attached cell binding receptor molecules, that asymmetric polymer tadpole nanostructure coated with a thermoresponsive poly(N-isopropylacrylamide) polymer with approximately 50% of this polymer in a globular conformation resulted in both high selectivity and rapid uptake into the triple breast cancer cell line MDA-MB-231. [Biomacromolecules] Abstract | Graphical Abstract

Modified Gaphene Oxide (GO) Particles in Peptide Hydrogels: A Hybrid System Enabling Scheduled Delivery of Synergistic Combinations of Chemotherapeutics

Scientists developed a homogeneous composite comprising modified GO nanoparticles embedded in a Max8 peptide hydrogel, which provides controlled kinetics and molar ratios of release of doxorubicin and gemcitabine. [J Mater Chem B] Abstract | Graphical Abstract

Optimization of Docetaxel Loading Conditions in Liposomes: Proposing Potential Products for Metastatic Breast Carcinoma Chemotherapy

In vivo experiment with BALB/c mice bearing 4T1 or TUBO breast carcinoma tumors showed that docetaxel-liposomes could significantly delay tumor growth and prolonged survival time in comparison with control and Taxotere groups at the similar dose of 8mg/kg. [Sci Rep] Full Article

Heterogeneity at the Invasion Front of Triple Negative Breast Cancer Cells

Researchers enriched live invading and matched non-invading SUM149 inflammatory breast cancer cells using a fluidic device and these two functionally distinct subpopulations were tested for differences in gene expression using a gene expression microarray. [Sci Rep] Full Article

Cytokines Secreted by Stromal Cells in Triple Negative Breast Cancer Microenvironment as Potential Targets for Cancer Therapy

Investigators performed a systematic analysis of cytokine factors secreted from four stromal components (fibroblasts, macrophages, lymphatic endothelial cells, and blood microvascular endothelial cells) induced by four triple negative breast cancer cell types. [Cancer Biol Ther] Abstract

Switchable Fluorescence of Doxorubicin for Label-Free Imaging of Bioorthogonal Drug Release

The authors discovered that the switchable fluorescence of doxorubicin could validate drug release upon its uncaging reaction with a highly specific chemical partner. [ChemMedChem] Abstract

Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells

Scientists investigated the combination effect of lower doses of thymoquinone and ferulic acid on the proliferation, apoptosis, and cell cycle of a breast cancer cell line MDA-MB 231. [Nutr Cancer] Abstract

Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News.

Breast Cancer-Derived Exosomes: Tumor Progression and Therapeutic Agents

The authors discuss the key function of breast cancer-derived exosomes in tumorgenesis and shed light on the possible clinical application of these exosomes in breast cancer treatment. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Alphamab Oncology Announces Clinical Supply Collaboration with Pfizer on KN026 in Combination with Ibrance^® (Palbociclib)

Alphamab Oncology announced that Jiangsu Alphamab Biopharmaceuticals Co., Ltd., has entered a clinical supply agreement with Pfizer Inc. to advance a clinical study to investigate KN026 in combination with Ibrance^®, an oral CDK4/6 inhibitor, in patients with previously-treated locally advanced and/or metastatic HER2-positive breast cancer. [Alpamab Oncology] Press Release

Dr. Roeland Nusse: Gairdner Award Recipient and Bio-Techne Board of Directors Member

Dr. Roeland Nusse has become one of the 2020 Canada Gairdner International Award recipients. [Bio Techne Corporation] Press Release

Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus

As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial

Universities Issue Hiring Freezes in Response to COVID-19

Numerous universities have made announcements about the suspension of hiring, including Miami University of Ohio, Wright State University, Villanova University, the University of Nevada, Reno, Indiana University, and the University of Auckland in New Zealand, which cites the travel ban affecting Chinese students as one of the main causes of its freeze. [The Scientist] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

Senior Scientist – Cancer Immunology and Immunotherapy (Genentech, Inc.)

Tenure Track Faculty Positions – Breast Cancer (Georgetown University Medical Center)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Position – Cancer Genomics and Epigenomics Research (NIH National Cancer Institute)

Postdoctoral Fellow – RAS Cancer Cell Biology (University of Luxembourg)

Group Leaders – Cancer Biology (Institute of Pharmacology and Structural Biology)

Postdoctoral Training Fellow – Endocrine Control Mechanisms (Institute of Cancer Research)

Postdoctoral Investigator – Breast Cancer Cell Biology (Florida Atlantic University)

Postdoctoral Research Position – Breast Cancer Research (The University of Texas)

Postdoctoral Position – Breast Cancer Metastasis (University of Kentucky)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Mammary Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.