| Vol. 12.23 – 18 June, 2020 |
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Scientists used a powerful validation-based insertion mutagenesis method to find that expression of a dominant-negative, truncated form of the histone deacetylase ZIP led to resistance to tamoxifen. [Proceedings of the National Academy of Sciences of the United States of America] |
| | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators report a new and unexpected function of snail in endothelium generation by breast cancer cells. They showed that high snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells. [Cell Death & Disease] |
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| Scientists performed subtype stratified analyses and identified key differences between ductal carcinoma in situ and invasive breast cancer that suggested subtype specific progression. [npj Breast Cancer] |
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| Researchers demonstrated protein aggregates and autophagy receptors, TAX1BP1 and NDP52, as potential endpoints for monitoring autophagy during drug development and clinical studies. [Cell Death & Disease] |
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| Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification. [Cell Death & Disease] |
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| Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model. [Scientific Reports] |
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| The authors provided evidence that N-acetyltransferase 1 was not just a xenobiotic metabolizing enzyme and might have a role in endogenous cellular metabolism. [Scientific Reports] |
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| Researchers showed that protein kinase C-ε promoted breast cancer cell survival not only by inhibiting apoptosis but also by inducing autophagy. [International Journal of Molecular Sciences] |
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| Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays. [Annals of Biomedical Engineering] |
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| The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast. [Current Opinion in Cell Biology] |
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| Eli Lilly and Company announced Verzenio®, in combination with standard adjuvant endocrine therapy, has met the primary endpoint of invasive disease-free survival, significantly decreasing the risk of breast cancer recurrence or death compared to standard adjuvant endocrine therapy alone. [Lilly] |
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| The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022. [ScienceInsider] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected. [Nature News] |
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| 2020-08-17 – 2020-08-19 Virtual |
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| Mayo Clinic – Rochester, Minnesota, United States |
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| University of Massachusetts Medical School – Worcester, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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| University of Vermont – Burlington, Vermont, United States |
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| City of Hope – Duarte, California, United States |
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| Georgetown University Medical Center – Washington, District of Columbia, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Cedars – Sinai medical School – Los Angeles, California, United States |
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