Mammary Cell News Volume 12.27 | Jul 16 2020

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    2020-07-16 | MCN 12.27


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.27 – 16 July, 2020
    TOP STORY

    Comprehensive Characterization of Claudin-Low Breast Tumors Reflects the Impact of the Cell-Of-Origin on Cancer Evolution

    Scientists showed that claudin-low breast cancers exhibited a significant diversity, comprising three main subgroups that emerged from unique evolutionary processes.
    [Nature Communications]

    Full Article

    Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.
    PUBLICATIONSRanked by the impact factor of the journal

    Cancer Cell CCR2 Orchestrates Suppression of the Adaptive Immune Response

    Researchers found that Ccr2 deletion in cancer cells led to reduced tumor growth and approximately two-fold longer survival in an orthotopic, isograft breast cancer mouse model. Their overall results established that C-C chemokine receptor type 2 (CCR2) signaling in cancer cells could orchestrate suppression of the immune response.
    [Journal of Experimental Medicine]

    Full ArticlePress Release
    Graphical Abstract

    Characterization of Circulating Breast Cancer Cells with Tumorigenic and Metastatic Capacity

    The authors describe the characterization of a novel circulating tumor cell (CTC)‐derived breast cancer cell line, designated CTC‐ITB‐01, established from a patient with metastatic estrogen receptor‐positive breast cancer, resistant to endocrine therapy.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Three-Dimensional Growth of Breast Cancer Cells Potentiates the Anti-tumor Effects of Unacylated Ghrelin and AZP-531

    This study characterized the effects of unacylated ghrelin on breast cancer cells, defined its mechanism of action, and explored the therapeutic potential of unacylated ghrelin or analog AZP-531.
    [eLife]

    Full Article

    Progesterone Receptor Membrane Component 1 Regulates Lipid Homeostasis and Drives Oncogenic Signaling Resulting in Breast Cancer Progression

    Scientists showed that progesterone receptor membrane component 1 might mediate proliferation and progression of breast cancer cells potentially by altering lipid metabolism and by activating key oncogenic signaling pathways, such as ERα expression and activation, as well as EGFR signaling.
    [Breast Cancer Research]

    Full Article

    Aspirin Attenuates YAP and β-Catenin Expression by Promoting β-TrCP to Overcome Docetaxel and Vinorelbine Resistance in Triple-Negative Breast Cancer

    Investigators demonstrated that changes in the expression of Yes-associated protein and β-catenin might be a promising predictive biomarker for neoadjuvant chemotherapy sensitivity in TNBC patients.
    [Cell Death & Disease]

    Full Article

    SOX9 is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis

    Researchers identified SOX9 protein as a “master regulator” of breast cancer cell survival and metastasis.
    [Molecular Cancer Research]

    Abstract

    LINC00160 Mediated Paclitaxel‐and Doxorubicin‐Resistance in Breast Cancer Cells by Regulating TFF3 via Transcription Factor C/EBPβ

    The authors identified a novel mechanism of LINC00160‐mediated chemoresistance via the C/EBPβ/TFF3 axis, highlighting the potential of LINC00160 for treating breast cancer with chemoresistance.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    TGF-β Regulates Sca-1 Expression and Plasticity of Pre-Neoplastic Mammary Epithelial Stem Cells

    Scientists provided evidence that TGF-β disrupted the lineage commitment and promoted the accumulation of tumor-initiating cells in pre-neoplastic cells.
    [Scientific Reports]

    Full Article

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    REVIEWS

    A Review of Nanotechnology-Based Approaches for Breast Cancer and Triple-Negative Breast Cancer

    This review focuses on conventional drug therapies, recent treatment strategies, and unique therapeutic approaches available for breast cancer and TNBC.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    EMA Validates and Grants Accelerated Assessment for Trastuzumab Deruxtecan for the Treatment of HER2 Positive Metastatic Breast Cancer

    Daiichi Sankyo Company, Limited announced that the European Medicines Agency has validated the Marketing Authorization Application for trastuzumab deruxtecan, a HER2 directed antibody drug conjugate, for the treatment of adults with unresectable or metastatic HER2 positive breast cancer who have received two or more prior anti-HER2 based regimens.
    [Daiichi Sankyo]

    Press Release

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Metastatic Breast Cancer

    Hackensack Meridian Health – Edison, New Jersey, United States

    Postdoctoral Fellow – Breast Surgery

    Northwestern University – Chicago, Illinois, United States

    Research Fellow – Molecular Pharmacology

    Mayo Clinic – Rochester, Minnesota, United States

    Assistant Scientists – Cell Cycle Regulation

    Georgetown University Medical Center – Washington, District of Columbia, United States

    Postdoctoral Associate – Cancer Bioengineering

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    > See All Jobs

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