 | | Vol. 12.29 – 30 July, 2020 |
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| Researchers showed that sex-determining region Y-box 9 (SOX9) was up-regulated after adenosine 5′-triphosphate treatment in breast cancer cells. In vitro invasion and migration assays demonstrated that knocking down SOX9 attenuated ATP-driven invasive capability.
[Oncogene] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signaling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer] |
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| Researchers demonstrated that hotspot mutant p53, p53-R273H, promoted cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a zinc finger transcription factor and a documented tumor suppressor.
[Cell Death & Disease] |
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| DHCR24 knockdown reduced whereas DHCR24 overexpression enhanced breast cancer stem‐like cell populations such as mammosphere and aldehyde dehydrogenase positive cell numbers. In addition, DHCR24 overexpression increased the expression of the Hedgehog pathway regulated genes.
[Cancer Science] |
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| Scientists investigated the combined therapeutic effects of an approved nutraceutical agent S‐adenosylmethionine and hypomethylating agent decitabine using the MDA‐MB‐231 xenograft model of breast cancer and found a pronounced reduction in mammary tumour volume and lung metastasis compared to the animals in the control and monotherapy treatment arms.
[Journal of Cellular and Molecular Medicine] |
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| Researchers found that knockdown of enhancer of zeste homolog 2 (EZH2) expression restored the expression of deletion gene 1 (DLC1) and inhibited the migration, invasion and proliferation, promoted the apoptosis, and blocked the cell cycle of MDA‐MB‐231 cells.
[Journal of Cellular and Molecular Medicine] |
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| This authors investigated the effects of H4R ligands on epithelial-mesenchymal transition and mammosphere formation as a surrogate assay for cancer stem cells in breast cancer cells with different invasive phenotype. They also investigated the participation of Src and TGF-β signaling in these events.
[Biochemical Pharmacology] |
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| Investigators reconstituted PTEN-deficient breast cancer cells with wild-type and mutant PTEN, demonstrating that restoration of PTEN expression converted cancer cells with mesenchymal traits to an epithelial phenotype and inhibited cancer stem cell activity.
[Scientific Reports] |
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| The authors found that breast cancer cells acquired alkaline phosphatase enzyme activity via placental alkaline phosphatase expression and suggested that breast calcification formation was closely associated with the PI3K-Akt signaling pathway.
[Scientific Reports] |
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| Scientists provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal receptor for activated C kinase 1 (RACK1) in breast cancer.
[British Journal of Pharmacology] |
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| The authors document the well‐known miR‐SNPs that are known to be associated with breast cancer. Two principals are discussed: SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; Changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.
[Journal of Cellular Physiology] |
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| Shanghai Henlius Biotech, Inc. and Accord Healthcare Limited jointly announced the European Commission has approved Zercepac® for the treatment of HER2-positive early breast cancer, HER2-positive metastatic breast cancer and HER2-positive metastatic gastric cancer.
[Henlius] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
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| August 19 – August 21
Virtual |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | University of Texas-Southwestern Medical Center – Dallas, Texas, United States |
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| | Georgetown University Medical Center – Washington, District of Columbia, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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