 | | Vol. 12.33 – 27 August, 2020 |
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| Using spatially defined organotypic culture, intravital microscopy of mammary tumors in mice and in silico modelling, scientists identified cell density regulation by three-dimensional tissue boundaries to physically control collective movement irrespective of the composition and stability of cell–cell junctions.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The functional requirement for integrin beta 3 (ITGB3) derived from its interactions with heparan sulfate proteoglycans and the process of integrin endocytosis, allowed the capture of extracellular vesicles and their endocytosis-mediated internalization.
[Nature Communications] |
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| Researchers revealed that Neu, PyMT and BRCA1-null mammary tumors contained distinct lineage-specific tumor propagating cells and this was reflective of the self-sustaining capabilities of lineage-specific stem/progenitor cells in the mammary epithelial hierarchy.
[elife] |
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| Investigators identified the pivotal roles of protein arginine methyltransferase 7 (PRMT7) in promoting endosomal focal adhesion kinase (FAK) signalling activation during breast cancer metastasis.
[elife] |
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| Scientists revealed that not only receptor tyrosine-protein kinase erbB-2 in the nucleus of TNBC (NErbB-2) canonical and alternative isoforms role as targets of therapy in TNBC, but also isoform c dominant oncogenic potential.
[Oncogene] |
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| Using early lesion breast cancer models, researchers demonstrated the effect of p38 suppression by human epidermal growth factor receptor 2 (Her2) on early dissemination was mediated by mitogen-activated protein kinase activated protein kinase 2 (MK2) and heat shock protein 27.
[Oncogene] |
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| Researchers found that the zinc finger e-box binding homeobox 1 (ZEB1) upregulated circular WWC3 expression, but not the linear WWC3 mRNA expression.
[Molecular Therapy-Nucleic Acids] |
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| Scientists hypothesized that WW domain-binding protein 2 (WBP2) was regulated by the hippo tumor suppressor pathway. The macrophage-stimulating protein (MST) was demonstrated to negatively regulate WBP2 expression in a kinase-dependent but large tumor suppressor kinase-independent manner.
[Cell Death & Disease] |
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| Authors used in vitro and in vivo models and discovered that MLN4924, a specific small molecule inhibitor of NEDDylation, restored estrogen-related receptor β (ERRβ) expression and culminated in a reduction in cell proliferation and migration of breast cancer cells.
[Cell Death & Disease] |
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| In three dimensional organotypic assays, peptide-exposed telomerase immortalised fibroblasts and primary cancer-associated fibroblasts from breast carcinoma patients both exhibited a markedly reduced pro-invasive ability of either HT1080 fibrosarcoma or MDA-MB-231 mammary carcinoma cells, respectively.
[Cancers] |
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| Scientists described the generation and characterization of two MDA-MB-231 breast cancer cell-line variants with reduced susceptibility to pleurocidin-family and mastoparan direct-acting anticancer peptides.
[Biomolecules] |
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| When investigators analyzed only the genes that were differentially expressed in the stem cell enriched fraction, clusters of downregulated genes were related to proliferation, while among the upregulated expression, cluster of genes related to cell adhesion, migration and cytoskeleton organization were observed.
[Scientific Reports] |
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| Authors discuss various roles of ginsenosides in the treatment of breast cancer, including apoptosis, autophagy, metastasis, epithelial-mesenchymal transition, epigenetic changes, combination therapy, and drug delivery system.
[Archives of Pharmacal Research] |
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| Odonate Therapeutics, Inc. announced positive top‑line results from CONTESSA, a Phase III study of tesetaxel in patients with metastatic breast cancer.
[Odonate Therapeutics, Inc.] |
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| May 30 – June 4, 2021
West Dover, Vermont, United States |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Myeloid Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Miami Sylvester Comprehensive Cancer Center – Miami, Florida, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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Cancer Stem Cell News
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