Mammary Cell News Volume 12.34 | Sep 3 2020

    By
    Justin.choi
    -
    0
    60







    2020-09-03 | MCN 12.34


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.34 – 3 September, 2020
    TOP STORY

    Oncogenic AURKA-Enhanced N6-Methyladenosine
    Modification Increases DROSHA mRNA Stability to Transactivate STC1 in Breast Cancer Stem-Like Cells

    DROSHA interacted with β-catenin to transactivate stanniocalcin 1 (STC1) in an RNA cleavage-independent manner, contributing to breast cancer stem-like cell properties.
    [Cell Research]

    Abstract


    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    An
    Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

    Investigators showed that the activities of the signaling network propagated as coordinated waves, biased by growth factor, drove actin-based protrusions in human epithelial cells.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Targeting
    Obesity-Induced Macrophages during Preneoplastic Growth Promotes Mammary Epithelial Stem/Progenitor Activity, DNA Damage and Tumor Formation

    To understand how macrophage-driven inflammation due to obesity enhanced tumor formation, mice were treated with immunoglobulin G or anti-F4/80 antibodies to deplete macrophages during preneoplastic growth.
    [Cancer Research]

    Abstract

    Honeybee
    Venom and Melittin Suppress Growth Factor Receptor Activation in HER2-Enriched and Triple-Negative Breast Cancer

    Mutational studies revealed a positively charged C-terminal melittin sequence mediated plasma membrane interaction and anticancer activity.
    [NPJ Precision Oncology]

    Full Article

    Inhibition of DNMT1 and ERRα Crosstalk Suppresses Breast Cancer via Derepression of
    IRF4

    Genetic or pharmacological studies uncovered a hitherto unknown feedforward molecular link between DNA methyltransferase (DNMT1) and the estrogen related receptor α (ERRα), a key transcriptional regulator of cellular metabolism.
    [Oncogene]

    Full Article

    The
    Cell-Surface Anchored Serine Protease TMPRSS13 Promotes Breast Cancer Progression and Resistance to Chemotherapy

    Human breast cancer cell culture models revealed that siRNA-mediated silencing of transmembrane protease, serine 13 (TMPRSS13) expression decreased proliferation, induced apoptosis, and attenuated invasion.
    [Oncogene]

    Abstract

    Extracellular
    Neuroglobin as a Stress-Induced Factor Activating Pre-Adaptation Mechanisms against Oxidative Stress and Chemotherapy-Induced Cell Death in Breast Cancer

    Scientists evaluated the possible role of neuroglobin, a monomeric globin that acts as a compensatory protein against oxidative and apoptotic processes, as part of breast cancer microenvironment.
    [Cancers]

    Full Article

    The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer

    Researchers found argonaute 2 (Ago2), a master regulator protein, associated with LIM and SH3 Protein 1 (LASP1) in response to C-X-C chemokine receptor type 4 activity.
    [Cancers]

    Full Article

    LIMK2
    Promotes the Metastatic Progression of Triple-Negative Breast Cancer by Activating SRPK1

    To determine the mechanism by which LIM domain kinase 2 (LIMK2) promoted TNBC metastatic progression, scientists performed stable isotope labeling by amino acids in cell culture based unbiased large-scale phosphoproteomics analysis.
    [Oncogenesis]

    Full Article

    Secreted
    Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPARα/ANGPTL4 and FAK

    The authors showed that co-culture with adipose tissue from high-fat diet induced obese C57BL/6 mice altered transcriptome profiles in TNBC cells, leading to upregulation of genes involved in inflammation and lipid metabolism, such as IL1B, PLIN2 and ANGPTL4.
    [Molecular Cancer Research]

    Abstract

    Tumor
    Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype

    A novel co-culture model of tumor organoids with autologous stromal cells significantly increased KRT14 expression and invasion of organoids from both luminal and basal murine breast cancer models.
    [Molecular Cancer Research]

    Abstract

    Artesunate,
    as a HSP70 ATPase Activity Inhibitor, Induces Apoptosis in Breast Cancer Cells

    Researchers evaluated the inhibitory effects of artesunate on HSP70 and Bcl-2 expression in two breast cancer cell lines, 4T1 and MCF-7.
    [International Journal of Biological Macromolecules]

    Abstract


    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    HIFs, Angiogenesis, and Metabolism: Elusive Enemies in Breast Cancer

    The authors discuss the pathophysiological role of hypoxia-inducible factors (HIF), angiogenesis, and metabolism in breast cancer and the challenges of targeting these features in breast cancer patients.
    [Journal of Clinical Investigation]

    AbstractFull Article

    Classical and Non-Classical Progesterone Signaling in Breast Cancers

    Investigators attempt to understand the classical and non-classical signaling role of progesterone in breast cancers because both nuclear and membrane receptors could become viable therapeutic options for breast cancer patients.
    [Cancers]

    Full Article

    The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

    The authors examine the basic knowledge of the role of mitomiRs in breast cancer and discuss their prospects as biomarkers or therapeutic targets.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    Treadwell
    Announces Initiation of Expansion Cohorts in Ongoing Phase 1 Study of Oral TTK Inhibitor, CFI-402257, in Patients with Breast Cancer and Additional Solid Tumors

    Treadwell Therapeutics announced the initiation of three expansion cohorts in its ongoing Phase I study evaluating CFI-402257, a selective and highly potent oral inhibitor of tyrosine threonine kinase, for the treatment of TNBC and additional solid tumors.
    [Treadwell Therapeutics (Business Wire)]

    Press Release

    Natera Announces Collaboration with Massachusetts General Hospital for a Prospective Randomized Clinical Trial in Early Stage Breast Cancer

    Natera, Inc. announced a collaborative agreement with Massachusetts General Hospital, related to an investigator-initiated multi-center, Phase II randomized clinical trial of Ribociclib for the treatment of ER-positive breast cancer, the first circulating tumor DNA based study of a CDK4/6 inhibitor in ER-positive early stage breast cancer.
    [Natera, Inc.]

    Press Release

    FEATURED EVENT

    European Society for Medical Oncology (ESMO) Breast Cancer

    May 10-12, 2021
    Berlin, Germany


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Fellow/Associate – Breast & Ovarian Cancer

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Position – Immune Microenvironment, Stem Cell, and Cancer

    Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Research Fellow – Brain Tumor Dormancy/Metastasis

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Associate Scientist – In Vivo
    Pharmacology

    Myeloid Therapeutics – Cambridge, Massachusetts, United States

    Research Associate – PcG-Mediated Mechanisms in Cancers

    University of Miami Sylvester Comprehensive Cancer Center – Miami, Florida, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Mammary Cell News
    Archives Contact Us
    Mammary Cell News Twitter