Mammary Cell News Volume 12.35 | Sep 10 2020

    0
    50








    2020-09-10 | MCN 12.35


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.35 – 10 September, 2020
    TOP STORY

    Targeting TRIM37-Driven Centrosome Dysfunction in 17q23-Amplified Breast Cancer

    Researchers showed that centrosome depletion induced synthetic lethality in cancer cells that contained the 17q23 amplicon, a recurrent copy number aberration that defined about 9% of all primary breast cancer tumors and was associated with high levels of genomic instability.
    [Nature]

    AbstractPress Release


    Scientific resources to support your stem cell research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    TRIM37 Controls Cancer-Specific Vulnerability to PLK4 Inhibition

    Low tripartite motif-containing 37 (TRIM37) levels accelerated acentrosomal spindle assembly and improved proliferation following polo-like kinase 4 (PLK4) inhibition, whereas high TRIM37 levels inhibited acentrosomal spindle assembly, leading to mitotic failure and cessation of proliferation.
    [Nature]

    Abstract

    Three-Dimensional
    Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

    Investigators demonstrated that breast cancer-derived extracellular vesicles activated liver sinusoidal endothelial cells in the liver-chip, inducing endothelial to mesenchymal transition and destruction of vessel barriers.
    [ACS Nano]

    AbstractGraphical Abstract

    Hedgehog
    Signaling Enables Repair of Ribosomal DNA Double-Strand Breaks

    Scientists found that glioma-associated oncogene family zinc finger 1was activated in TNBC cells in response to ionizing radiation (IR) and localized to ribosomal DNA (rDNA) sequences in response to both global double-strand breaks (DSBs) generated by IR and site-specific DSBs in rDNA.
    [Nucleic Acids Research]

    Full Article

    Methylation
    of EZH2 by PRMT1 Regulates Its Stability and Promotes Breast Cancer Metastasis

    Researchers demonstrated that meR342-EZH2 decreased enhancer of zeste homolog 2 (EZH2) target gene expression, but increased breast cancer cell epithelial–mesenchymal transition, invasion and metastasis.
    [Cell Death & Differentiation]

    Abstract

    TV-circRGPD6
    Nanoparticle Suppresses Breast Cancer Stem Cells-Mediated Metastasis via miR-26b/YAF2 Axis

    Mechanistic analyses determined that hTERT promoter-driven VP16-GAL4-WPRE integrated systemic amplifier delivery composite vector-circular RNA RGPD6 (TV-circRGPD6) suppressed breast cancer stem cell-mediated metastasis via miR-26b/YAF2 axis.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Unique
    Cellular Protrusions Mediate Breast Cancer Cell Migration by Tethering to Osteogenic Cells

    Investigators discovered an alternative “migration-by-tethering” mechanism through which cancer cells gained momentum to migrate by adhering to mesenchymal stem cells or osteoblasts.
    [npj Breast Cancer]

    Full Article

    Cyclin
    E Expression Is Associated with High Levels of Replication Stress in Triple-Negative Breast Cancer

    To uncover the relation between oncogene expression, replication stress, and clinical features of breast cancer subgroups, researchers immunohistochemically analyzed the expression of a panel of oncogenes and markers of replication stress in breast tumor tissues prior to treatment.
    [npj Breast Cancer]

    Full Article

    Aptamer
    Targeted Therapy Potentiates Immune Checkpoint Blockade in Triple-Negative Breast Cancer

    Scientists investigated the effectiveness of a novel combination treatment with the platelet-derived growth factor receptor β aptamer and anti-programmed cell death-ligand 1 monoclonal antibody in TNBC.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    M2
    Macrophage-Induced lncRNA PCAT6 Facilitates Tumorigenesis and Angiogenesis of Triple-Negative Breast Cancer through Modulation of VEGFR2

    Investigators revealed that prostate cancer-associated transcript 6 (PCAT6) boosted TNBC proliferation, migration, and angiogenesis both in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    A
    miR-210-3p Regulon That Controls the Warburg Effect by Modulating HIF-1α and p53 Activity in Triple-Negative Breast Cancer

    Ectopic expression of miR-210-3p enhanced glucose uptake, lactate production, extracellular acidification rate, colony formation ability, and reduced serum starvation-induced cell apoptosis.
    [Cell Death & Disease]

    Full Article

    Molecular
    Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams

    Scientists analyzed the in vivo molecular response to proton therapy and its efficacy in a MDA-MB-231 TNBC xenograft model.
    [Cancers]

    Full ArticleGraphical Abstract


    Keep current with the latest in organoid research.
    REVIEWS

    Counteracting
    Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells

    Investigators outline the prospects and directions for a better understanding and re-purposing of metformin as an anti-cancer/chemo-sensitizing drug in the treatment of breast cancer.
    [Cancers]

    Full Article

    Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer

    The authors review the function of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway and the various classes of PI3K pathway inhibitors that have been developed to disrupt this pathway signaling for the treatment of hormone-receptor-positive breast cancer.
    [Drugs]

    Abstract

    miRNAs
    Modulate the Dichotomy of Cisplatin Resistance or Sensitivity in Breast Cancer: An Update of Therapeutic Implications

    Investigators summarize the general understandings of miRNA-regulated biological processes in breast cancer, particularly focused on the role of miRNA in cisplatin resistance/sensitivity.
    [Anti-Cancer Agents in Medicinal Chemistry]

    Abstract

    INDUSTRY AND POLICY NEWS

    Knight Therapeutics Announces Filling of Supplement to a New Drug Submission for NERLYNX® (neratinib) to Treat HER2-Positive Metastatic Breast Cancer

    Knight Therapeutics Inc. announced the filing of NERLYNX®for receptor tyrosine-protein kinase erbB-2-positive metastatic breast cancer in Canada.
    [Knight Therapeutics Inc.]

    Press Release

    Onxeo Receives Notice of Allowance from USPTO for New Patent Strengthening Protection of Asidna via Systemic Administration in the United States

    Onxeo S.A. announced that it had received a Notice of Allowance from the US Patent and Trademark Office for a new patent in the United States covering the systemic administration of AsiDNA for the treatment of TNBC and chemo-resistant lung cancer, alone or in combination with chemotherapy, radiotherapy or other tumor DNA-damaging agents.
    [Onxeo S.A.]

    Press Release


    Recent Studies Reveal High Performance of Lunit AI in Breast Cancer Detection

    Recent studies have shown that Lunit’s artificial intelligence solution was as accurate as average radiologists when it came to identifying breast cancer.
    [Lunit Inc (PRNewswire LLC)]

    Press Release

    FEATURED EVENT

    Cancer Research & Oncology 2020

    October 7 – 8
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Clinical Breast Cancer Therapy

    German Cancer Research Center – Heidelberg, Germany

    Research
    Assistant – Breast Cancer 3D Modelling

    University of Cambridge – Cambridge, United Kingdom

    Postdoctoral
    Fellow/Associate – Breast & Ovarian Cancer

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Position – Immune Microenvironment, Stem Cell, and Cancer

    Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Research Fellow – Brain Tumor Dormancy/Metastasis

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Mammary Cell News
    Archives Contact Us
    Mammary Cell News Twitter