 | | Vol. 12.40 – 15 October, 2020 |
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| Investigators identified that SF3B1 mutations in mammary epithelial and breast cancer cells induced a recurrent pattern of aberrant splicing leading to activation of AKT and NF-kB, enhanced cell migration, and accelerated tumorigenesis.
[Journal of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that with direct cell-cell contact, tumor microenvironment-derived endothelial cells provided the Notch ligand Jagged1 to neighboring breast cancer stem cells, leading to Notch1-dependent upregulation of Zeb1.
[Nature Communications] |
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| By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
[Nature Communications] |
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| Investigators presented a strategy for determining the labeling efficiency of quantum dot labeling of HER2 in overexpressing breast cancer cells.
[Nano Letters] |
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| Researchers uncovered that the transmembrane proline rich γ-carboxyglutamic acid protein 4 (PRRG4) promoted breast cancer metastasis by downregulating Robo1.
[Oncogene] |
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| Scientists elaborated on the role of oxidative stress-responsive kinase 1 (OSR1) in breast cancer metastasis and the specific regulatory mechanism.
[Oncogene] |
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| Factor that bound to the inducer of short transcripts‐1 (FBI-1) enhanced the resistance of TNBC cells to chemotherapeutic agents by repressing the expression of micoRNA-30c targeting the pregnane X receptor (PXR).
[Cell Death & Disease] |
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| As checkpoint kinase 1 (Chk1) was associated with the DNA damage response (DDR), researchers investigated the effect of miR-320c on DDR in TNBC cells.
[Oncogenesis] |
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| Using human TNBC cell lines for in vitro studies, investigators found that, unlike native tumor–endothelial cells extracellular vesicles (EVs), anti-IL-3R-EVs increased apoptosis and reduced cell viability and migration.
[Oncogenesis] |
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| Scientists uncovered that estrogen receptor-positive breast cancer cells cultured within extracellular matrix -scaffolds had an increase in ER signaling that occured via a MAPK-dependent, but estrogen-independent manner.
[Molecular Cancer Research] |
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| Researchers probed the importance of O-GlcNAc transferase activity for the survival of tamoxifen-sensitive and tamoxifen-resistant breast cancer cells.
[Scientific Reports] |
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| The authors discuss novel bispecific antibodies for TNBC and emerging TNBC targets for future bispecific antibody development.
[Trends in Cancer] |
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| Investigators highlight various models of lymphatic metastasis, their potential pitfalls, and other tools available to study lymphatic metastasis including imaging modalities and -omic studies.
[Journal of Mammary Gland Biology and Neoplasia] |
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| Savran Technologies, Inc. announced the completion of an important Phase II multi-center clinical trial conducted at 20 sites across the country utilizing its unique detection platform.
[Savran Technologies, Inc.(BusinessWire Inc.)] |
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| January 9 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | Medical University of Vienna – Vienna, Austria |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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