 | | Vol. 12.42 – 29 October, 2020 |
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| Scientists found that fructose triggered breast cancer metastasis through the ketohexokinase-A signaling pathway. Molecular experiments showed that ketohexokinase-A, rather than ketohexokinase-C, was necessary and sufficient for fructose-induced cell invasion.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that expression of ADAR1, specifically its p150 isoform, was required for the survival of TNBC cell lines. In TNBC cells, knockdown of ADAR1 attenuated proliferation and tumorigenesis.
[Oncogene] |
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| The authors investigated the function of a new tumor suppressor microRNA, miR-488, and its molecular mechanism of metastasis in breast cancers.
[Cell Death & Disease] |
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| Investigators report the preparation of carbon nanodots bearing biotin as a targeting agent (CDs-PEG-BT), which were able to load high amounts of irinotecan to be released in a pulsed on-demand fashion. CDs-PEG-BT had narrow size distribution, stable red luminescence, and high photothermal conversion in the near-infrared region, allowing imaging of MDA-MB231 and MCF-7 cancer cells and killing them by photothermal and chemotherapeutic insults.
[Cancers] |
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| lncRNA MAFG-AS1 was shown to be up-regulated and associated with poor prognosis in ER+ breast cancer. Functionally, down-regulation of MAFG-AS1 could inhibit cell proliferation and promote apoptosis.
[Aging] |
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| Scientists explored the role of MAP17 protein shaping tumor evolution and showed that in breast cancer, cells increased MAP17 levels in tumors by demethylation induced multiple changes in gene expression through specific miRNAs downregulation.
[Oncogenesis] |
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| Researchers combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
[Scientific Reports] |
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| Investigators collected human milk samples from healthy and sub-acute mastitis-suffering mothers, during the course of mastitis and after symptoms disappeared. Total (DNA-based) and active (RNA-based) microbiota were analyzed by 16S rRNA gene sequencing and qPCR. Mammary epithelial cell lines were exposed to milk pellets, and levels of the pro-inflammatory interleukin IL8 were measured.
[Scientific Reports] |
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| Scientists showed that CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate and ATP production in human breast cancer cells in a RUNX2-independent manner.
[Oncotarget] |
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| The authors discuss BRCA1 and BRCA2 cancer biology and current modeling systems that will guide the design of future drug discovery endeavors and highlight areas requiring improvement.
[Biochimica et Biophysica Acta-Reviews on Cancer] |
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| Investigators examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.
[Cancers] |
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| Olema Oncology announced a clinical collaboration agreement with Novartis to evaluate OP-1250, a complete estrogen receptor (ER) antagonist and a selective ER degrader, in combination with each of Kisqali® and Piqray® in patients with recurrent, locally advanced or metastatic estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer.
[Olema Oncology, Inc.] |
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| Polyphor AG completed recruitment in its FORTRESS Phase III study of balixafortide in metastatic breast cancer. A total of 411 patients were recruited, including 323 in the third line cohort and 88 patients in the second line cohort.
[Polyphor AG] |
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| March 17 – March 19, 2021
Virtual |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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| | University of Oslo – Oslo, Norway |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Institute of Cancer Research – London, England, United Kingdom |
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