 | | Vol. 12.47 – 3 December, 2020 |
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| Researchers report that Transforming Growth Factor-β (TGFβ) treatment triggered a fast and widespread increase in chromatin accessibility in about 80% of the enhancers of normal mouse mammary epithelial-gland cells, irrespective of whether they were activated, repressed, or not regulated by TGFβ.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified that ion flow through gap junctions promoted peripheral cell swelling in a loaded breast cancer model.
[Nature Communications] |
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| The authors demonstrated that in TNBC cells, the dual specificity tyrosine-regulated kinase 2 (DYRK2) phosphorylates HSF1, promoting its nuclear stability and transcriptional activity.
[Cell Death & Differentiation] |
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| Scientists performed a proteomic kinome analysis in ESR1 Y537S mutant cells to identify hyperactivated kinases in ESR1 mutant cells. They validated Recepteur d’Origine Nantais (RON) and PI3K hyperactivity through phospho-immunoblot analysis, organoid growth assays, and in an in vivo patient-derived xenograft metastatic model.
[British Journal of Cancer] |
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| Researchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacted cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
[Laboratory Investigation] |
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| The chemoadjuvant effects of a methanolic extract from the leaves of Pseudolysimachion rotundum var. subintegrum and an active component isolated from the plant, verminoside, were evaluated.
[Scientific Reports] |
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| Scientists assessed the potential of phenolic compounds from Pistacia lentiscus to enhance the production of milk constituents in bovine mammary epithelial cells.
[Scientific Reports] |
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| Researchers showed that ZNF750 negatively regulated cell migration and invasion in breast cancer cells; in particular, ZNF750 bound and recruited KDM1A and HDAC1 on the LAMB3 and CTNNAL1 promoters.
[Cell Death Discovery] |
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| The role of one isoform, ppGalNAc-T4, in breast cancer cell lines was investigated. The expression of ppGalNAc-T4 was found to be negatively associated with the migration of breast cancer cells.
[Journal of Biological Chemistry] |
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| The authors provide an overview of the therapeutic option for brain metastases from breast cancer that is currently available and outlines potential new approaches for tackling these deadly secondary tumors.
[British Journal of Cancer] |
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| The authors summarize the current treatments for breast cancer and the potential use of virotherapy in the treatment of the disease. They also discuss the use of oncolytic viruses as immunotherapeutics and the rational combination of oncolytic viruses with other therapeutics for optimal treatment of breast cancer. Finally, they outline the progress made in virotherapy for breast cancer and the shortcomings that need to be addressed for this novel therapy to move to the clinic for better treatment of breast cancer.
[Cancer Gene Therapy] |
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| MacroGenics, Inc. announced that it has partnered with EVERSAN to commercialize margetuximab in the United States if approved.
[MacroGenics, Inc.] |
| | The L’Oréal-UNESCO For Women in Science Middle East Regional Young Talents Program, in partnership with Khalifa University of Science and Technology, awarded six winners in the Post-doctorate Researchers and PhD Students categories where Dr. Lama AlAbdi (KSA), Dr. Isra Marei (Qatar), and Dr. Maryam Tariq Khaleel Alhashmi (UAE) each received EUR20,000 in the Post-doctorate Researchers category.
[L’Oréal-UNESCO (Business Today)] |
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| June 23 – June 26, 2021
Hamburg, Germany |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | BC Cancer Research Centre – Vancouver, British Columbia, Canada |
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| | Research Institute of the McGill University Health Centre – Montreal, Quebec, Canada |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | The University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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