 | | Vol. 13.00 – 7 January, 2021 |
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| The authors identified the SOX4 transcription factor as an important resistance mechanism to T cell-mediated cytotoxicity for TNBC cells.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that played a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo.
[Nature Communications] |
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| Scientists report that under hypoxic conditions, alternative splicing of MBD2 was suppressed, favoring the production of MBD2a which facilitated breast cancer metastasis.
[Cancer Research] |
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| Researchers investigated the relationship between Th1 immune response and the proteasomal degradation pathway, in HER2 sensitive and resistant cells.
[Molecular Therapy] |
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| Investigators used malignant and nonmalignant human breast cell lines to demonstrate how controlled oxidative stress was mediated by specifically nanoengineered indium tin oxide nanoparticles could selectively induce cell death in the cancer cells while reducing the oxidative stress in the normal cells and supporting their proliferation.
[ACS Applied Materials & Interfaces] |
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| Researchers indicated that breast cancer cell-derived exosomes played an important role in promoting breast cancer bone metastasis, which was associated with the formation of a pre-metastatic niche via transferring miR-21 to osteoclasts.
[Theranostics] |
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| Scientists found that METTL5 showed strong substrate preference toward the 18S A1832 motif but not the other reported m6A motifs.
[Cell Reports] |
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| The authors analyzed the epigenetic alterations of long non-coding RNAs (lncRNAs) at important regulatory elements in three breast cancer subtypes.
[Molecular Therapy-Nucleic Acids] |
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| Researchers utilized an inducible, conditional knockout of Tfap2c to elucidate the role of AP-2γ in the maintenance and differentiation of mammary stem cells.
[Stem Cell Reports] |
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| Investigators evaluated the mechanism by which minichromosome maintenance protein 3 (MCM3) influenced endocrine resistance and its predictive/prognostic potential in estrogen receptor-positive breast cancer.
[npj Breast Cancer] |
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| Scientists identified tsRNAs in plasma that could distinguish patients with breast cancer from healthy controls. Based on high-throughput sequencing, 15 significantly upregulated tsRNAs were selected and assessed in cell supernatants and cell lines.
[npj Breast Cancer] |
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| Researchers showed that cancer-associated fibroblasts-induced activation of interferon signaling in claudin-low TNBCs resulted in chemoresistance.
[British Journal of Cancer] |
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| The authors consolidate all known inhibitors of breast tumor kinase (BRK) activity and highlight the connection between drug action and BRK-mediated effects.
[Theranostics] |
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| Investigators outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy] |
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| Ambrx Inc. announced that the FDA granted ARX788 Fast Track Designation as monotherapy for the treatment of advanced or metastatic HER2-positive breast cancer patients who have received one or more prior anti-HER2 based regimens in the metastatic setting.
[Ambrx Inc.] |
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| Everest Medicines announced that it has initiated the submission of a New Drug Application to the Health Sciences Authority of Singapore for sacituzumab govitecan-hziy for the treatment of patients with metastatic TNBC who have received at least two prior therapies for metastatic disease.
[Everest Medicines] |
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| January 13 – 14, 2021
Virtual |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Medical University of Gdańsk – Gdańsk, Poland |
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| | University of Iowa Carver College of Medicine – Iowa City, Iowa, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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