Mammary Cell News Volume 13.05 | Feb 11 2021

May 12, 2022

2021-02-11 | MCN 13.05

Mammary Cell News by STEMCELL Technologies

Vol. 13.05 – 11 February, 2021

TOP STORY

Targeted Immunotherapy for HER2-Low Breast Cancer with 17p Loss

Researchers demonstrated that α-amanitin–conjugated trastuzumab potentiated the human epidermal growth factor receptor 2 (HER2)-targeted therapy and exhibited superior efficacy in treating HER2-low breast cancer with 17p loss.
[Science Translational Medicine]

Abstract

Virtual Conference Exhibition: Organoids

PUBLICATIONSRanked by the impact factor of the journal

Tetraarsenic Hexoxide Enhances Generation of Mitochondrial ROS to Promote Pyroptosis by Inducing the Activation of Caspase-3/GSDME in Triple-Negative Breast Cancer Cells

The authors showed that tetraarsenic hexoxide induced the pyroptotic cell death through activation of mitochondrial reactive oxygen species (ROS)-mediated caspase-3/gasdermin E (GSDME) pathway, thereby suppressing tumor growth and metastasis of TNBC cells.
[Cell Death & Disease]

Full Article

Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype

Scientists demonstrated that the alternative splicing event-mediated decrease of very-long-chain ceramides led to enhanced cancer cell proliferation and migration.
[Cell Death & Disease]

Full Article

Integrative Analyses of scRNA-Seq and scATAC-Seq Reveal CXCL14 as a Key Regulator of Lymph Node Metastasis in Breast Cancer

Investigators identified a novel cell subpopulation with an abnormally high expression level of CXCL14 in the positive lymph node of breast cancer patients.
[Human Molecular Genetics]

Abstract

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Using a V-well cell adhesion assay or flow cytometry analysis with fluorescent beads, the authors found that both TM domain 12-Fc and TM domain 23-Fc inhibited the binding between β1 integrin of human breast cancer-derived cell lines and fibronectin.
[Biomedicines]

Full Article

The Aryl Hydrocarbon Receptor Undergoes Chaperone-Mediated Autophagy in Triple-Negative Breast Cancer Cells

Researchers report that aryl hydrocarbon receptor (AHR) undergone chaperone-mediated autophagy in MDA-MB-468 TNBCs.
[International Journal of Molecular Sciences]

Full Article

The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential

Using a battery of established breast cancer cell lines with either a well-differentiated epithelial or poorly differentiated mesenchymal phenotype, scientists observed subtype-specific protein expression of RAC1B and RAC1.
[Cells]

Full Article

miRNA10b-Directed Nanotherapy Effectively Targets Brain Metastases from Breast Cancer

Investigators extended the application of MN-anti-miR10b to a model of breast cancer metastatic to the brain. They demonstrated delivery to the metastatic lesions and obtained evidence of a therapeutic effect manifested as inhibition of metastatic progression.
[Scientific Reports]

Full Article

Lipid Tethering of Breast Tumor Cells Reduces Cell Aggregation during Mammosphere Formation

Researchers developed a method to reduce tumor cell aggregation and increased the probability that the observed mammospheres formed were clonal in origin.
[Scientific Reports]

Abstract

Receptor-Type Protein Tyrosine Phosphatase Alpha (PTPα) Mediates MMP14 Localization and Facilitates Triple-Negative Breast Cancer Cell Invasion

Investigators report a novel role for PTPα in promoting TNBC cell invasion in vitro and in vivo. They showed that PTPα knockdown reduced extracellular matrix degradation and cellular invasion of MDA-MB-231 cells through Matrigel.
[Molecular Biology of the Cell]

Abstract Full Article

Klebsiella pneumoniae Infection Causes Mitochondrial Damage and Dysfunction in Bovine Mammary Epithelial Cells

The authors determined the role of mitochondrial damage in the pathogenicity of K. pneumoniae on bovine mammary epithelial cells, by assessing several classical indicators of mitochondrial dysfunction, as well as differentially expressed genes.
[Veterinary Research]

Full Article

Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart

REVIEWS

Sympathetic Activity in Breast Cancer and Metastasis: Partners in Crime

Scientists discuss clinical perspectives and developments on the use of β-adrenergic receptor inhibitors for breast cancer management and treatment.
[Bone Research]

Full Article

Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression

Investigators recapitulate the multifaceted action exerted by focal adhesion kinase and its prognostic significance in breast cancer.
[Cancers]

Full Article

INDUSTRY AND POLICY NEWS

Lassen Therapeutics Announces Collaboration with the Olivia Newton-John Cancer Research Institute to Study the Role of IL-11 Signaling and Inhibition in Preclinical Models of Breast Cancer

Lassen Therapeutics announced a collaboration with the Olivia Newton-John Cancer Research Institute. The collaboration will study the role of IL-11 signaling and assess the potential of monoclonal antibodies that block IL-11 signaling in preclinical models of TNBC.
[Lassen Therapeutics]

Press Release

FEATURED EVENT

Targeted Immunotherapy for HER2-Low Breast Cancer with 17p Loss

Tetraarsenic Hexoxide Enhances Generation of Mitochondrial ROS to Promote Pyroptosis by Inducing the Activation of Caspase-3/GSDME in Triple-Negative Breast Cancer Cells

Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype

Integrative Analyses of scRNA-Seq and scATAC-Seq Reveal CXCL14 as a Key Regulator of Lymph Node Metastasis in Breast Cancer

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

The Aryl Hydrocarbon Receptor Undergoes Chaperone-Mediated Autophagy in Triple-Negative Breast Cancer Cells

The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential

miRNA10b-Directed Nanotherapy Effectively Targets Brain Metastases from Breast Cancer

Lipid Tethering of Breast Tumor Cells Reduces Cell Aggregation during Mammosphere Formation

Receptor-Type Protein Tyrosine Phosphatase Alpha (PTPα) Mediates MMP14 Localization and Facilitates Triple-Negative Breast Cancer Cell Invasion

Klebsiella pneumoniae Infection Causes Mitochondrial Damage and Dysfunction in Bovine Mammary Epithelial Cells

Sympathetic Activity in Breast Cancer and Metastasis: Partners in Crime

Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression

Lassen Therapeutics Announces Collaboration with the Olivia Newton-John Cancer Research Institute to Study the Role of IL-11 Signaling and Inhibition in Preclinical Models of Breast Cancer

The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

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Postdoctoral Position – Breast Cancer

Postdoctoral Associate – Breast Tumorigenesis

Academic Surgical Pathologist – Breast Pathology

Postdoctoral Researcher – Somatic Mutations in Ribosomal Proteins in Cancer

Medical Scientist – Breast Cancer

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