 | | Vol. 13.09 – 11 March, 2021 |
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| Researchers found that perturbing Brca1/p53 in luminal progenitors induced aberrant alveolar differentiation pre-malignancy accompanied by pro-tumorigenic changes in the immune compartment.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists introduced an optimized method for orthotopic organoid transplantation in mice, which included injection of organoids and estrogen pellets without the need for surgery.
[Nature Protocols] |
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| Researchers combined analysis of pubertal mouse mammary glands, a 3D-printed engineered tissue model, and computational models of morphogenesis to investigate the origin and the dynamics of the global bias in epithelial orientation during pubertal mammary development.
[Current Biology] |
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| Scientists characterized the energy-related metabolic features of breast cancers through integrative analyses of multiple datasets with genomics, transcriptomics, metabolomics, and single-cell transcriptome profiling.
[Molecular Therapy] |
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| Investigators observed significantly promoted onset, growth, metastasis, and multiplicity of HER2 tumors by mediator subunit 1 overexpression.
[Cell Reports] |
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| Researchers showed that phosphorylation and activation of HER3 in luminal breast cancer cells occurred in a paracrine manner and was mediated by NRG1 expressed by cancer-associated fibroblasts.
[Oncogene] |
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| Investigators demonstrated a mechanistic link between connective tissue growth factor (CTGF) and enhanced aerobic glycolysis in TNBC.
[Oncogene] |
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| When comparing breast tumors to adjacent normal ducts, PTEN expression was decreased and the PRC2-associated methyltransferase EZH2 was increased.
[Communications Biology] |
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| The authors showed that the loss of the junctional scaffold protein MAGI1 was associated with a bad prognosis in luminal breast cancer, and promoted tumorigenesis.
[Scientific Reports] |
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| Investigators examined the natural compound pentagalloyl glucose (PGG) effects on TNF-α activated TNBC cell lines. The results obtained showed that PGG reduced the expression of the cytokine GRO-α/CXCL1.
[Scientific Reports] |
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| Scientists review the biogenesis, regulatory mechanisms, and biological functions of circRNAs in TNBC and summarize the relationship between circRNAs expression and the clinicopathology, diagnosis, and prognosis of patients with TNBC.
[Journal of Hematology & Oncology] |
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| The authors summarize preclinical studies supporting the oncogenic role of EphA2 in breast cancer, lung cancer, glioblastoma, and melanoma while delineating the differing roles of canonical and noncanonical EphA2 signaling in each setting.
[Oncogene] |
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| Greenwich LifeSciences, Inc., focused on the development of GP2, immunotherapy to prevent breast cancer recurrences in patients who have previously undergone surgery announced the hiring of Jaye Thompson as Vice President Clinical and Regulatory Affairs to oversee the upcoming GP2 Phase III clinical trial on a full time basis.
[Greenwich LifeSciences, Inc.] |
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| June 14 – 18, 2021
Virtual |
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| | Tulane School of Medicine – New Orleans, Louisiana, United States |
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| | University of Illinois at Urbana-Champaign – Urbana, Illinois, United States |
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| | Gilead Sciences, Inc. – Zug, Switzerland |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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