Mammary Cell News Volume 13.16 | Apr 29 2021

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    2021-04-29 | MCN 13.16


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.16 – 29 April, 2021
    TOP STORY

    Arginine and Lysine Methylation of MRPS23 Promotes Breast Cancer Metastasis through Regulating OXPHOS

    Scientists unveiled a unique mechanism of controlling oxidative phosphorylation (OXPHOS) by arginine and lysine methylation and point to the impact of the protein arginine methyltransferase 7-SET-domain-containing protein 6-mitochondrial ribosomal protein S23 (MRPS23) axis during breast cancer metastasis.
    [Oncogene]

    Abstract

    Explore scientific events this May with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    BBIT20 Inhibits Homologous DNA Repair with Disruption of the BRCA1-BARD1 Interaction in Breast and Ovarian Cancer

    The authors used 2D and 3D cell cultures, patient-derived cell lines, and xenograft mouse models to unveil the antitumor activity and underlying molecular mechanism of action of dregamine 5‐bromo‐pyridin‐2‐ylhydrazone (BBIT20).
    [British Journal of Pharmacology]

    Abstract

    Inhibition of Retinoic Acid Receptor α Phosphorylation Represses the Progression of Triple-Negative Breast Cancer via Transactivating miR-3074-5p to Target DHRS3

    The anti-tumor activity of hypo-phosphorylated retinoic acid receptor α was investigated in TNBC cell models and a xenograft mouse model.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Tumor-Derived Exosomal circPSMA1 Facilitates the Tumorigenesis, Metastasis, and Migration in Triple-Negative Breast Cancer (TNBC) through miR-637/Akt1/β-Catenin (Cyclin D1) Axis

    Investigators explored the novel mechanisms by which exosome-contained circRNAs promoted tumor development and metastasis in TNBC.
    [Cell Death & Disease]

    Full Article

    PD-L1 Tumor-Intrinsic Signaling and Its Therapeutic Implication in Triple-Negative Breast Cancer

    Researchers demonstrated a potentially novel mechanism by which PD-L1 promoted the epithelial-mesenchymal transition (EMT) in TNBC cells by suppressing the destruction of the EMT transcription factor Snail.
    [JCI Insight]

    Full Article

    Genetic Interactions among Brca1, Brca2, Palb2, and Trp53 in Mammary Tumor Development

    Analyses of mouse mammary glands and cultured human cells showed that combined loss of BRCA1 and PALB2 led to high levels of reactive oxygen species and increased apoptosis, implicating oxidative stress in the delayed tumor development in Brca1;Palb2 double conditional knockout mice.
    [npj Breast Cancer]

    Full Article

    Crosstalk between Progesterone Receptor Membrane Component 1 and Estrogen Receptor α Promotes Breast Cancer Cell Proliferation

    The authors identified classical and nonclassical endocrine signaling mechanisms that could alter cell proliferation through possible crosstalk between progesterone receptor, estrogen receptor α, and progesterone receptor membrane component 1, a membrane receptor frequently observed in breast cancer cells.
    [Laboratory Investigation]

    Abstract

    The Nek2 Centrosome-Mitotic Kinase Contributes to the Mesenchymal State, Cell Invasion, and Migration of Triple-Negative Breast Cancer Cells

    Investigators report that overexpression of NIMA‐related kinase 2 (Nek2) in MCF10A cells drove centrosome amplification/chromosome instability and aneuploidy.
    [Scientific Reports]

    Full Article

    Inhibition of eEF2K Synergizes with Glutaminase Inhibitors or 4EBP1 Depletion to Suppress Growth of Triple-Negative Breast Cancer Cells

    Researchers showed that genetic or pharmacological inhibition of eukaryotic elongation factor-2 kinase (eEF2K) cooperated with glutamine starvation, and synergized with glutaminase inhibitors to suppress the growth of diverse TNBC cell lines.
    [Scientific Reports]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Metabolic Pathways in Obesity-Related Breast Cancer

    The author focuses on the mechanistic evidence for a link between obesity, dysregulated cellular metabolism, and breast cancer.
    [Nature Reviews Endocrinology]

    Abstract

    How Should We Define Mammary Stem Cells?

    Investigators highlight misconceptions, suggest definitions of stem and progenitor cells, and propose a way forward in the search for an understanding of mammary stem cells.
    [Trends in Cell Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    G1 Therapeutics Announces Initiation of Phase III Registrational Study of COSELA™ (Trilaciclib) in Triple-Negative Breast Cancer (TNBC)

    G1 Therapeutics, Inc. announced the initiation of PRESERVE 2, a pivotal Phase III, randomized, double-blind, placebo-controlled study of COSELA™ in patients receiving first- or second-line gemcitabine and carboplatin chemotherapy for locally advanced unresectable or metastatic TNBC.
    [G1 Therapeutics, Inc.]

    Press Release

    FDA Advisory Committee Votes in Favor of Maintaining Accelerated Approval of Genentech’s Tecentriq® for PD-L1-Positive, Metastatic Triple-Negative Breast Cancer

    Genentech, Inc. announced the FDA Oncologic Drugs Advisory Committee voted seven to two in favor of maintaining accelerated approval of Tecentriq® in combination with chemotherapy for the treatment of adults with unresectable locally advanced or metastatic TNBC whose tumors express PD-L1.
    [Genentech, Inc.]

    Press Release

    FEATURED EVENT

    Cambridge Cancer Epigenetics Club: Paola Scaffidi

    June 4, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Translational Breast Cancer Research

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Lecturer – Breast Cancer Systems Biomedicine

    University of Southampton – Southampton, England, United Kingdom

    Research Technician – Breast Cancer Research

    King’s College London – London, England, United Kingdom

    Postdoctoral Position – Breast Cancer Therapy

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Senior Manager – Medical Affairs Oncology

    Gilead Sciences, Inc. – Austria, Vienna



    > See All Jobs

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