Mammary Cell News Volume 13.18 | May 13 2021

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    2021-05-13 | MCN 13.18


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.18 – 13 May, 2021
    TOP STORY

    Avasopasem Manganese Synergizes with Hypofractionated Radiation to Ablate Tumors through the Generation of Hydrogen Peroxide

    In vitro non-small lung cancer and mammary adenocarcinoma models showed that auranofin-induced inhibition of glutathione- and thioredoxin-dependent hydrogen peroxide metabolism selectively enhanced Avasopasem manganese-induced killing of cancer cells compared to normal cells.
    [Science Translational Medicine]

    Abstract
    Webinar: The Promise of Organoid Medicine
    PUBLICATIONSRanked by the impact factor of the journal

    FUT8-Mediated Aberrant N-Glycosylation of B7H3 Suppresses the Immune Response in Triple-Negative Breast Cancer

    Researchers dissected the mechanisms by which TNBC cells initiate immunosuppression by inducing glycosylation B7 homolog 3 protein (B7H3) stabilization, and suggested the fucosyltransferase (FUT8)-B7H3 axis as a potential prognostic biomarker and therapeutic target for TNBC patients.
    [Nature Communications]

    Full Article

    Disruption of FOXO3a-miRNA Feedback Inhibition of IGF2/IGF-1R/IRS1 Signaling Confers Herceptin Resistance in HER2-Positive Breast Cancer

    The authors demonstrated that the insulin-like growth factor/ insulin-like growth factor-1/ receptor/ insulin receptor substrate-1 (IGF2/IGF-1R/IRS1) signaling was aberrantly activated in Herceptin-resistant breast cancer via disruption of the FOXO3a-miRNA negative feedback inhibition.
    [Nature Communications]

    Full Article

    Bedaquiline, an FDA-Approved Drug, Inhibits Mitochondrial ATP Production and Metastasis In Vivo, by Targeting the Gamma Subunit (ATP5F1C) of the ATP Synthase

    Scientists found that Bedaquiline had no effect on the growth of non-tumorigenic mammary epithelial cells or primary tumors in vivo.
    [Cell Death & Differentiation]

    Full Article

    Cryopreservation of Human Cancers Conserves Tumor Heterogeneity for Single-Cell Multi-Omics Analysis

    Using the Chromium 10X platform, investigators sequenced a total of ~ 120,000 cells from fresh and cryopreserved replicates across three primary breast cancers, two primary prostate cancers and a cutaneous melanoma.
    [Genome Medicine]

    Full Article

    PI5P4Ks Drive Metabolic Homeostasis through Peroxisome-Mitochondria Interplay

    Researchers identified a role for peroxisomal phosphatidylinositol 4,5-bisphosphate generated by the phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) in maintaining energy balance, and noted that inhibition of the PI5P4Ks in cancer cells led to decreased cell viability.
    [Developmental Cell]

    Full Article

    Targeting Epigenetic and Post-Transcriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth

    Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
    [Cancer Research]

    Abstract

    The N Terminus of Orai1 Couples to the AKAP79 Signaling Complex to Drive NFAT1 Activation by Local Ca2+ Entry

    Researchers assessed the coupling of Orai1 Ca2+ channels with nuclear factor of activated T cells in MCF-7 cells to help identify an approach for generation of immunosuppressant drugs.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    PI(3,4)P2-Mediated Membrane Tubulation Promotes Integrin Trafficking and Invasive Cell Migration

    Scientists used the invadopodium model system of Src-transformed fibroblast and MDA-MB-231 cell lines to investigate the functional role of PI(3,4)P2 in adhesion signaling.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    The Extracellular-Regulated Protein Kinase 5 (ERK5) Enhances Metastatic Burden in Triple-Negative Breast Cancer through Focal Adhesion Protein Kinase (FAK)-Mediated Regulation of Cell Adhesion

    The authors revealed that ERK5 was critical for maintaining the invasive capability of TNBC cells through FAK activation, and reported that a high level of ERK5 is a predictive marker of metastatic breast cancer.
    [Oncogene]

    Full Article

    Novel miR-5088-5p Promotes Malignancy of Breast Cancer by Inhibiting DBC2

    The relationship between Deleted in Breast Cancer 2 (DBC2) and miR-5088-5p was analyzed by scientists, and both of which were suggested as potential novel biomarkers for the diagnosis of breast cancer patients.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Myeloid-Derived Suppressor Cells Regulate the Immunosuppressive Functions of PD-1−PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB Axis in Breast Cancer

    Researchers reported that blocking PD-1/PD-L1 interaction between myeloid-derived suppressor cells and B cells could reverse the immunosuppressive functions of PD-1−PD-L1+ Bregs.
    [Cell Death & Disease]

    Full Article

    CXCR4 Intracellular Protein Promotes Drug Resistance and Tumorigenic Potential by Inversely Regulating the Expression of Death Receptor 5

    Scientists revealed that the presence of CXCR4 intracellular protein augments paclitaxel resistance and pro-tumorigenic functions using breast and colon cancer cells lines, and that targeting this protein may be critical to dampen the pro-tumorigenic functions of CXCR4.
    [Cell Death & Disease]

    Full Article

    How to prioritize and manage your research projects
    REVIEWS

    Redefining Macrophage and Neutrophil Biology in the Metastatic Cascade

    Researchers describe the origin and role of the macrophages, neutrophils, and their progenitors in the metastatic cascade and suggest strategies that might enhance cancer therapy.
    [Immunity]

    Full Article

    CircRNAs: Role in Human Diseases and Potential Use as Biomarkers

    The authors discuss the roles played by circular RNAs in human diseases, including several organ-specific cancers, and evaluate their potential as reliable biomarkers of disease course and treatment efficacy.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    IMV’s Lead Immunotherapy to Be Investigated in Breast Cancer

    IMV, Inc. announced that its lead compound, maveropepimut-S will be investigated in patients with hormone receptor positive/HER2-negative breast cancer.
    [IMV, Inc.]

    Press Release

    Dr. Connie Eaves Elected into the Prestigious Royal Society

    Dr. Connie Eaves was recognized for her development of robust functional methods to quantify and characterize distinct types of primitive blood and mammary cell precursors- now considered gold standards.
    [The University of British Columbia]

    Press Release

    FEATURED EVENT

    Precision Oncology: Translating Discovery to the Clinic

    June 21 – 24, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Breast Cancer Hormone Therapy Resistance

    Baylor College of Medicine – Houston, Texas, United States

    Scientist – Stromal Biology

    Bristol Myers Squibb – Redwood City, California, United States

    Postdoctoral Fellowships – Clinical Cancer Prevention

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Translational Breast Cancer Research

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Translational Epigenetics and Women’s Cancer

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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