 | | Vol. 13.28 – 29 July, 2021 |
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| Scientists found that differentiation-inducing factor-1 (DIF-1) induced phosphorylation of AMPK and Raptor and dephosphorylation of p70S6K in multiple TNBC cell lines.
[Oncogene] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| MICAL1 gene disruption by CRISPR/Cas9 in MDA MB 231 human breast cancer cells knocked out protein expression, which affected F-actin organization, cell size and motility.
[Cancer Letters] |
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| Researchers showed a new role for ETV7, a transcriptional repressor member of the ETS family, in promoting breast cancer stem-like cells plasticity and resistance to chemo- and radiotherapy in breast cancer cells.
[Cell Death & Disease] |
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| C5aR1-positive neutrophil-secreted IL1β and TNFα cooperatively activated ERK1/2 signaling, which phosphorylated WTAP at serine341 and thereby stabilized WTAP protein. The stabilization of WTAP further promoted RNA m6A methylation of ENO1, impacting the glycolytic activity of breast cancer cells.
[Cell Death Discovery] |
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| Investigators showed that sublethal doxorubicin treatment led to increased migration and invasion in otherwise non-invasive MCF7 breast cancer cells.
[Breast Cancer Research] |
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| The authors demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.
[Molecular Cancer Research] |
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| Following conjugation to β-lactam-derivatized monomethyl auristatin F, tropomyosin receptor kinase B cell surface protein-targeting dual variable domain-antibody–drug conjugates showed potency against multiple breast cancer cell lines, including TNBC cell lines.
[Scientific Reports] |
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| In recurrent tumor cells, whole-genome duplication (WGD) slowed tumor formation, growth rate and opposed the process of recurrence, while WGD promoted the growth of primary tumors.
[Scientific Reports] |
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| Musashi-1 was artificially downregulated in MCF-7 breast cancer cells and implications for cancer stem cell markers, cell apoptosis and apoptosis regulator p21, proliferation and radiation response were analyzed via flow cytometry and colony formation.
[Journal of Cancer Research and Clinical Oncology] |
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| Researchers engineered human breast cancer cells to express either Akaluc or Antares2 for bioluminescence imaging and tdTomato or zsGreen for ex vivo fluorescence microscopy.
[Molecular Imaging and Biology] |
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| To scrutinize hormone response heterogeneity among breast cancer (BCa) tumor cells, scientists developed a precision tool to specifically measure estrogen receptor alpha (ER-α)-66, ER-α46, and eight ER-signaling proteins with single-cell resolution in the highly hetero-clonal MCF-7 BCa cell line.
[PLoS One] |
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| The L-Arginine (Arg) auxotrophic cancerous cells like hepatocellular carcinoma, human colon cancer, leukemia, and breast cancer cells were sensitive to Arg depriving enzymes treatment due to low expression of crucial enzymes argininosuccinate synthetase, argininosuccinate lyase, and ornithine transcarbamylase.
[Cancer Chemotherapy and Pharmacology] |
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| The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
[Capitol Weekly] |
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| September 22 – 24, 2021
Virtual |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Mayo Clinic Health System – Rochester, Minnesota, United States |
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