Mammary Cell News Volume 13.32 | Aug 26 2021

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    2021-08-26 | MCN 13.32


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.32 – 26 August, 2021
    TOP STORY

    Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds

    Seven CADA compounds were examined for reduction of cellular sortilin expression and progranulin-induced breast cancer stem cell propagation.
    [Journal of the American Chemical Society]

    AbstractGraphical Abstract

    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    Co-Targeting CDK4/6 and AKT with Endocrine Therapy Prevents Progression in CDK4/6 Inhibitor and Endocrine Therapy-Resistant Breast Cancer

    The authors showed that triple inhibition with fulvestrant, CDK4/6i and AKT inhibitor durably impaired growth of breast cancer cells, prevented progression and reduced metastasis of tumor xenografts resistant to CDK4/6i-fulvestrant combination or fulvestrant alone.
    [Nature Communications]

    Full Article

    Restoring Mammary Gland Structures and Functions with Autogenous Cell Therapy

    In vitro chemical induction with RepSox generated chemically induced mammary epithelial cells (MECs) with milk secreting functions from goat ear fibroblasts (GEFs). Single-cell RNA sequencing revealed that during the reprogramming process, GEFs may have sequentially undergone embryonic ectoderm-like and different MEC developmental states.
    [Biomaterials]

    Full Article

    Drivers and Suppressors of Triple-Negative Breast Cancer

    Researchers found that except for SP1, the other tethering partners of ERβ were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Parsing β-Catenin’s Cell Adhesion and Wnt Signaling Functions in Malignant Mammary Tumor Progression

    Employing the mouse mammary tumor virus–PyMT mouse model of metastatic breast cancer, scientists compared the complete elimination of β-catenin with the specific ablation of its signaling outputs in mammary tumor cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Circ-EIF6 Encodes EIF6-224aa to Promote TNBC Progression via Stabilizing MYH9 and Activating Wnt/Beta-Catenin Pathway

    The authors identified a circRNA termed circ-EIF6, which predicted a poorer prognosis and correlated with clinicopathological characteristics in a cohort of TNBC patients. Functionally, they showed that circ-EIF6 promoted the proliferation and metastasis of TNBC cells in vitro and in vivo.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Osthole Inhibits the Migration and Invasion of Highly Metastatic Breast Cancer Cells by Suppressing ITGα3/ITGβ5 Signaling

    Investigators showed that the expression of integrin α3 (ITGα3) and integrin β5 (ITGβ5) was upregulated in highly metastatic MDA-MB-231, MDA-MB-231BO breast cancer cell lines but was downregulated in poorly metastatic MCF-7 breast cancer cell line, which may have been the key targets of osthole’s anti-metastatic action.
    [Acta Pharmacologica Sinica]

    Abstract

    Ethanol-Based Garlic Extract Prevents Malignant Evolution of Non-Invasive Breast Tumor Cells Induced by Moderate Hypoxia

    Homemade ethanol-based garlic extract was administered to breast tumor cell lines grown under moderate hypoxia. Cell cycle, epithelial-to-mesenchymal transition and cancer stem cell markers were evaluated.
    [Biomedicine & Pharmacotherapy]

    AbstractGraphical Abstract

    Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution

    Researchers presented comprehensive proteomes comprised of >9,000 total proteins, and >15,000 phosphopeptides, from normal primary human mammary epithelia at lineage resolution from ten women ranging in age from 19 to 68. Results were biologically validated with cell-based assays.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Quercetin against MCF7 and CAL51 Breast Cancer Cell Lines: Apoptosis, Gene Expression, and Cytotoxicity of Nano-Quercetin

    Investigators evaluated the anti breast-cancer activity, biocompatibility, and toxicity of poly(d,l)-lactic-co-glycolic acid-encapsulated quercetin nanoparticles. Activity against CAL51 and MCF7 cell lines was assessed by DNA fragmentation assays, fluorescence microscopy, and acridine-orange, and propidium-iodide double-stainings.
    [Nanomedicine]

    AbstractGraphical Abstract

    CircRNA Circ-PDCD11 Promotes Triple-Negative Breast Cancer Progression via Enhancing Aerobic Glycolysis

    The authors investigated the function and underlying mechanisms of novel circPDCD11 in TNBC aerobic glycolysis and revealed that circPDCD11 expression was significantly upregulated in TNBC tissues and cells.
    [Cell Death Discovery]

    Full Article

    Translocation of Intracellular CD24 Constitutes a Triggering Event for Drug Resistance in Breast Cancer

    Scientists evaluated the phenotype switching associated with drug resistance in breast cancer cell lines and highlighted the role of the cancer stem cell marker CD24 in the dynamics of cell plasticity and the acquirement of drug resistance.
    [Scientific Reports]

    Full Article

    Desensitization of Human Breast Progenitors by a Transient Exposure to Pregnancy Levels of Estrogen

    Hormone receptor positive, reduction mammoplasty-derived human breast epithelial progenitors were exposed to a short-term, pregnancy-level of estradiol, and their subsequent response to estradiol stimulation was analyzed.
    [Scientific Reports]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    LncRNA and Breast Cancer: Progresses from Functional and Regulatory Mechanism to Challenges and Opportunities of Clinical Treatment

    Investigators elucidate the general characteristics, potential mechanisms and targeted therapy of long non-coding RNAs (LncRNAs) and discuss the emerging functions of LncRNAs in breast cancer.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    BriaCell and ImaginAb Announce Collaboration to Evaluate Immunotherapy Imaging Technology in Advanced Breast Cancer

    BriaCell Therapeutics Corp., a clinical-stage biotechnology company specializing in targeted immunotherapies for advanced breast cancer, jointly announced a multi-year, non-exclusive license agreement with ImaginAb Inc., a biotechnology company focused on developing next-generation immuno oncology imaging agents and radiopharmaceutical therapies.
    [BriaCell Therapeutics Corp.]

    Press Release

    FEATURED EVENT

    6th World Congress of the Tissue Engineering and Regenerative Medicine International Society

    November 15 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Breast Cancer Immunology and Immunotherapy

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Principal Medical Scientist – Oncology

    Gilead Sciences, Inc. – Foster City, California, United States

    Research Associate – Breast Cancer Research

    Baylor College of Medicine – Houston, Texas, United States

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    > See All Jobs

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