 | | Vol. 13.33 – 2 September, 2021 |
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| To understand the mechanism of the bone-tropism of ER+ tumors, and to identify liquid biopsy biomarkers for patients with high risk of bone metastasis, researchers examined the secreted extracellular vesicles and cytokines from bone-tropic breast cancer cells.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the epithelial-like and mesenchymal-like subpopulations of breast cancer stem-like cells demonstrated different levels of dormancy and tumorigenicity in lungs.
[Nature Communications] |
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| The authors found that nuclear factor-kB (NF-κB) p65 was a new substrate of the F-box and WD-repeat-containing protein 2 (FBXW2), and that the FBXW2-p65 axis was a crucial regulator of SOX2-induced stemness in breast cancer.
[Cell Death & Differentiation] |
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Investigators reported that the single nucleotide polymorphism (SNP) rs4971059, 1 of 65 new breast cancer risk loci identified in a recent genome-wide association study, functioned as an active enhancer of TRIM46 expression. TRIM46 promoted breast cancer cell proliferation and chemoresistance in vitro and accelerated tumor growth in vivo.
[EMBO Journal] |
| | Researchers developed dual-mechanism estrogen receptor (ER) inhibitors that caused alternate, noncanonical structural perturbations of the receptor ligand-binding domain to antagonize proliferation in ER-positive breast cancer cells and in allele-specific resistance models.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors manipulated tripartite motif–containing 47 (TRIM47) expression in estrogen receptor–positive breast cancer cells MCF-7 and its 4-hydroxytamoxifen (OHT)-resistant derivative OHTR, which was established in a long-term culture with OHT. TRIM47 promoted both MCF-7 and OHTR cell proliferation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| TCGA analysis was performed to identify the clinical relevance of short stature homeobox 2 (SHOX2) in breast cancer. Molecular regulations and alterations were assessed by Western blotting, immunoprecipitation, immunohistochemistry, qRT-PCR, chromatin immunoprecipitation coupled with qPCR, and ChIP/re-ChIP.
[Journal of Experimental & Clinical Cancer Research] |
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| Integrated affinity purification combined with mass spectrometry and TCGA analysis identified a cell cycle-related E3 ubiquitin ligase, checkpoint with forkhead and ring finger domains (CHFR), as a key negative regulator of zinc finger E-box-binding homeobox 1 (ZEB1) in TNBC.
[Cell Death & Disease] |
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| In cell lines, BRCA1 loss was associated with stabilized cyclin E1 during the cell cycle, and BRCA1 siRNA led to increased cyclin E1 in association with reduced phospho-cyclin E1 T62.
[npj Breast Cancer] |
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| Scientists presented an experimental model for human luminal progenitor cells that enabled single, primary cells isolated from normal tissue to generate complex branched structures resembling the ductal morphology of low-grade carcinoma of no special type.
[Journal of Pathology] |
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| Researchers used a xenograft model of spontaneous metastasis to the liver from an ectopic tumour employing a metastatic TNBC cell line. Atorvastatin was provided to sensitise metastatic cells, followed by chemotherapy.
[British Journal of Cancer] |
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| Silencing small nucleolar RNA host gene 1 (SNHG1) inhibited tumorigenesis in breast cancer both in vitro and in vivo. Mechanistically, SNHG1 functioned as a competing endogenous RNA to promote TERT expression by sponging miR-18b-5p in breast cancer.
[Cell & Bioscience] |
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| The functional roles of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ)–dishevelled-associated activator of morphogenesis 1 (DAAM1) axis and their regulator microRNA-613 in breast cancer cells and associated molecular mechanisms were demonstrated in vitro.
[Cell Death Discovery] |
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| The authors provide an overview of currently available molecular assays and testing modalities that have prognostic, predictive, and therapeutic value. These include multi-gene assays for invasive breast cancer and ductal carcinoma in situ, and companion tests to detect PIK3CA mutations and NTRK fusions.
[Journal of Molecular Diagnostics] |
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| Scientists review diagnostic criteria and prognostic parameters of breast neoplasms of special histotypes. Specifically, adenoid cystic carcinoma, adenomyoepithelioma, acinic cell carcinoma, mucoepidermoid carcinoma, tall cell carcinoma with reverse polarity, and secretory carcinoma are discussed.
[Virchows Archiv] |
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| Genentech, Inc. announced that the company has made the decision to voluntarily withdraw the US accelerated approval for Tecentriq® in combination with chemotherapy for the treatment of adults with unresectable locally advanced or metastatic TNBC whose tumors express PD-L1, as determined by a US FDA-approved test.
[Genentech, Inc.] |
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| HUTCHMED initiated a Phase Ib/II study of fruquintinib in combination with BeiGene’s tislelizumab in patients with advanced triple negative breast cancer or advanced endometrial cancer in the US. This trial is to explore the potential for the addition of a highly selective vascular endothelial growth factor receptor inhibitor, fruquintinib, to anti-programmed death-1 antibody tislelizumab in inducing activity to immune checkpoint inhibitors.
[HUTCHMED, Ltd.] |
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| October 19, 2021
London, England, United Kingdom |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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