 | | Vol. 13.38 – 14 October, 2021 |
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| Scientists identified MINDY1, a member that belongs to the motif interacting with Ubcontaining novel DUB family (MINDY), as a potential deubiquitylase of estrogen receptor α in breast cancer.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that TRIM31 was downregulated in breast cancer tissues and negatively correlated with breast cancer progression. Both gain- and loss-of-function assays indicated that TRIM31 inhibited the proliferation, colony formation, migration, and invasion of breast cancer cells.
[Cell Death & Disease] |
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| Investigators demonstrated that tumors harboring biallelic RAD51B alteration were deficient in homologous recombination DNA repair deficiency, as evidenced by analysis of sequencing data and in vitro functional assays.
[npj Breast Cancer] |
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| Scientists investigated the activity of QBS10072S in vitro with various cell lines including the human TNBC cell line MDA-MB-231 and its brain-tropic derivative MDA-MB-231-BR3, where QBS10072S was found to be preferentially toxic to TNBC cells.
[Molecular Cancer therapeutics] |
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| Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.
[Breast Cancer Research] |
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| Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.
[Journal of Cell Science] |
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| Investigators conducted a qRT-PCR assay to measure the expression of downregulated RNA in cancer (DRAIC) and other downstream target genes. They uncovered that DRAIC was expressed at a high level in breast cancer cells.
[Cancer Gene Therapy] |
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| The authors systematically studied the role of FAM49B in the proliferation, metastasis, apoptosis, and chemoresistance of breast cancer, as well as the corresponding molecular mechanisms and downstream target.
[Cancer Cell International] |
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| Researchers evaluated FBXO43 expression in breast cancer (BC) and analyzed The Cancer Genome Atlas. RT-qPCR and western blotting were utilized to detect FBXO43 expression in BC cell lines.
[Journal of Translational Medicine] |
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| Scientists investigated the effects of sauchinone on the growth of breast cancer cells along with the underlying molecular mechanisms. Results showed that sauchinone treatment markedly inhibited the proliferation, migration, and invasion of breast cancer cells.
[Bioscience Reports] |
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| The authors present the problem of overtreatment in early-stage breast cancer, review evidence supporting the use of anthracyclines in the pre-taxane era, analyze comparative trials evaluating taxanes with or without anthracyclines in biologically unselected and selected patient populations.
[npj Breast Cancer] |
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| Researchers summarize the pre-clinical characterization of ESR1 mutations and their association with clinical outcomes in metastatic breast cancer and primary disease.
[British Journal of Cancer] |
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| Rhizen Pharmaceuticals AG announced that it has commenced dosing in a Phase II trial to evaluate Tenalisib in patients with locally advanced or metastatic breast cancer.
[Rhizen Pharmaceuticals (BusinessNewsWire, Inc.)] |
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| Agilent Technologies Inc. announced its Ki-67 IHC MIB-1 pharmDx (Dako Omnis) is now FDA approved as an aid in identifying patients with early breast cancer at high risk of disease recurrence.
[Agilent Technologies, Inc.] |
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| November 8 – 10, 2021
Virtual |
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| | Medical University of Vienna – Vienna, Austria |
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| | City of Hope – Los Angeles, California, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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