| Vol. 13.39 – 21 October, 2021 |
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| The authors reported that DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediated by the increased secretion of IL11, which was extremely important for cancer progression. [Molecular Therapy-Nucleic Acids] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used the breast cancer mouse model MMTV-PyMT, and constructed a single-cell atlas of 31,778 cells from four distinct stages of tumor progression, during which malignant transition occured. [Cell Death & Disease] |
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| Researchers employed various in vitro along with in vivo assays and explored the effects of circGFRA1 in the progress of HER-2-positive breast cancer (BC) and interactions of circGFRA1, miR-1228 and AIFM2 in HER-2-positive BC. [Journal of Cellular and Molecular Medicine] |
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| Scientists reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and cancer stem cell-like characteristics of TNBC cells. [FEBS Journal] |
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| The authors investigated the cell viability and electrical response of graphene oxide (GO), in terms of resistivity and impedance towards the breast cancer cells and normal breast cells, by varied pH and concentration of GO. [Scientific Reports] |
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| Researchers demonstrated the versatile applicability of the new MMTV-Flp strain and manipulated genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpressed ERBB2, and in a new KRAS-associated mammary cancer model. [Scientific Reports] |
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| Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human induced pluripotent stem cells in a scalable fashion. [Scientific Reports] |
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| Scientists reported that IFN-γ and insulin possessed pro-proliferative effects in breast cancer and non-cancer cell lines, respectively, which were dependent on increased ASCT2-mediated glutamine transport. [Life Sciences] |
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| The authors reported that the combination of curdione and docetaxel (DTX) strengthened the DTX-induced pro-apoptotic effects in TNBC cells and identified its involved signaling pathways. [Bioengineered] |
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| The authors review the current knowledge of NEAT1 expression and functions in breast cancer, highlighting its established role in postnatal mammary gland development. [British Journal of Cancer] |
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| Scientists illustrated and summarized the correlations between endocrine therapy resistance in breast cancer and prolactin, as well as the pathophysiological mechanisms and clinical practices. [Journal of Cellular and Molecular Medicine] |
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| Investigators perform a systematic review of epidemiological evidence on the association between light-at-night exposure and breast cancer risk, using a dose–response meta-analysis and examining the shape of the relation. [International Journal of Health Geographics] |
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| Celcuity, Inc. announced a clinical trial collaboration with the University of Rochester Wilmot Cancer Center and Puma Biotechnology to conduct a Phase II clinical trial that will evaluate the efficacy and safety of NERLYNX®, and Xeloda®. [Celcuity, Inc. (BusinessWire, Inc.)] |
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| The Menarini Group and Radius Health, Inc. announced positive topline results from the EMERALD study evaluating elacestrant as a monotherapy versus the standard of care for the treatment of ER+/HER2- advanced or metastatic breast cancer. [Menarini Group] |
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| November 9 – 10, 2021 Montpellier, France |
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| Institute of Cancer Research – London, United Kingdom |
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| Medical University of Vienna – Vienna, Austria |
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| City of Hope – Los Angeles, California, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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