Mammary Cell News Volume 13.39 | Oct 21 2021

    0
    76







    2021-10-21 | MCN 13.39


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.39 – 21 October, 2021
    TOP STORY

    DGUOK-AS1 Acts as a Tumor Promoter through Regulating miR-204-5p/IL11 Axis in Breast Cancer

    The authors reported that DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediated by the increased secretion of IL11, which was extremely important for cancer progression.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract
    Enjoy your weekend. Your cells will too. Reduce medium acidosis with mTeSRâ„¢ Plus.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Transcriptomics Reveal the Heterogeneity and Dynamic of Cancer Stem-Like Cells during Breast Tumor Progression

    Investigators used the breast cancer mouse model MMTV-PyMT, and constructed a single-cell atlas of 31,778 cells from four distinct stages of tumor progression, during which malignant transition occured.
    [Cell Death & Disease]

    Full Article

    CircGFRA1 Facilitates the Malignant Progression of HER-2-Positive Breast Cancer via Acting as a Sponge of miR-1228 and Enhancing AIFM2 Expression

    Researchers employed various in vitro along with in vivo assays and explored the effects of circGFRA1 in the progress of HER-2-positive breast cancer (BC) and interactions of circGFRA1, miR-1228 and AIFM2 in HER-2-positive BC.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    EGFR Is a Pivotal Player of the E2/ERβ – Mediated Functional Properties, Aggressiveness and Stemness in Triple-Negative Breast Cancer Cells

    Scientists reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and cancer stem cell-like characteristics of TNBC cells.
    [FEBS Journal]

    Full Article

    Cell Viability and Electrical Response of Breast Cancer Cell Treated in Aqueous Graphene Oxide Solution Deposition on Interdigitated Electrode

    The authors investigated the cell viability and electrical response of graphene oxide (GO), in terms of resistivity and impedance towards the breast cancer cells and normal breast cells, by varied pH and concentration of GO.
    [Scientific Reports]

    Full Article

    Dual Recombinase Action in the Normal and Neoplastic Mammary Gland Epithelium

    Researchers demonstrated the versatile applicability of the new MMTV-Flp strain and manipulated genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpressed ERBB2, and in a new KRAS-associated mammary cancer model.
    [Scientific Reports]

    Full Article

    Human Induced Pluripotent Stem Cell-Derived Platelets Loaded with Lapatinib Effectively Target HER2+ Breast Cancer Metastasis to the Brain

    Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human induced pluripotent stem cells in a scalable fashion.
    [Scientific Reports]

    Full Article

    The Pro-Proliferative Effect of Interferon-γ in Breast Cancer Cell Lines Is Dependent on Stimulation of ASCT2-Mediated Glutamine Cellular Uptake

    Scientists reported that IFN-γ and insulin possessed pro-proliferative effects in breast cancer and non-cancer cell lines, respectively, which were dependent on increased ASCT2-mediated glutamine transport.
    [Life Sciences]

    AbstractGraphical Abstract

    Combinative Treatment of Curdione and Docetaxel Triggers Reactive Oxygen Species (ROS)-Mediated Intrinsic Apoptosis of Triple-Negative Breast Cancer Cells

    The authors reported that the combination of curdione and docetaxel (DTX) strengthened the DTX-induced pro-apoptotic effects in TNBC cells and identified its involved signaling pathways.
    [Bioengineered]

    Full Article
    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Expression and Functions of Long Non-coding RNA NEAT1 and Isoforms in Breast Cancer

    The authors review the current knowledge of NEAT1 expression and functions in breast cancer, highlighting its established role in postnatal mammary gland development.
    [British Journal of Cancer]

    Abstract

    Prolactin and Endocrine Therapy Resistance in Breast Cancer: The Next Potential Hope for Breast Cancer Treatment

    Scientists illustrated and summarized the correlations between endocrine therapy resistance in breast cancer and prolactin, as well as the pathophysiological mechanisms and clinical practices.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Light at Night and Risk of Breast Cancer: A Systematic Review and Dose–Response Meta-Analysis

    Investigators perform a systematic review of epidemiological evidence on the association between light-at-night exposure and breast cancer risk, using a dose–response meta-analysis and examining the shape of the relation.
    [International Journal of Health Geographics]

    Full Article
    INDUSTRY AND POLICY NEWS

    Celcuity Announces Clinical Trial Collaboration with University of Rochester Wilmot Cancer Center and Puma to Study Patients with Breast Cancer Brain Metastases

    Celcuity, Inc. announced a clinical trial collaboration with the University of Rochester Wilmot Cancer Center and Puma Biotechnology to conduct a Phase II clinical trial that will evaluate the efficacy and safety of NERLYNX®, and Xeloda®.
    [Celcuity, Inc. (BusinessWire, Inc.)]

    Press Release

    Menarini Group and Radius Health Announce Positive Phase III Topline Results from the EMERALD Trial Evaluating Elacestrant in Breast Cancer

    The Menarini Group and Radius Health, Inc. announced positive topline results from the EMERALD study evaluating elacestrant as a monotherapy versus the standard of care for the treatment of ER+/HER2- advanced or metastatic breast cancer.
    [Menarini Group]

    Press Release
    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Training Fellow – Target Validation and DNA Damage

    Institute of Cancer Research – London, United Kingdom

    Postdoctoral Position – Translational Oncology

    Medical University of Vienna – Vienna, Austria

    Postdoctoral Fellow – Tumor Heterogeneity and Development of Resistant Cancer

    City of Hope – Los Angeles, California, United States

    Postdoctoral Fellow – Molecular and Cellular Oncology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Immunology

    Weill Cornell Medicine – New York, New York, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mammary Cell News Twitter