 | | Vol. 13.44 – 2 December, 2021 |
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| Researchers examined 400 patient-derived breast epithelial and breast cancer explant cultures grown in various 3D matrix scaffolds, and found that ERα was primarily regulated by the matrix stiffness.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using breast cancer as a model of solid tumor metastasis to the bone marrow, scientists applied large-scale quantitative 3D imaging to characterize temporal changes in the bone marrow microenvironment during disease progression.
[Nature Communications] |
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| The authors employed tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full epithelial-mesenchymal transition (EMT) in the MMTV-PyMT mouse model of metastatic breast cancer.
[Developmental Cell] |
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| Investigators demonstrated that MLK4 promoted TNBC chemoresistance by regulating the pro-survival response to DNA-damaging therapies and identified a novel function of MLK4 in the regulation of DNA damage response signaling.
[Cell Death & Disease] |
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| Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had an enhancing effect on breast cancer cells migration and invasion.
[Cell Death & Disease] |
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| Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.
[Acta Pharmacologica Sinica] |
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| Researchers examined the significance of olfactory receptor (OR) transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs.
[iScience] |
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| The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.
[Scientific Reports] |
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| Scientists utilized a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with in vitro 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion.
[Molecular Biology of the Cell] |
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| Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.
[Bioengineered] |
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| The authors discuss the biological understanding of tumor-infiltrating lymphocytes (TILs), their analytical and clinical validity and efforts towards the clinical utility in breast cancer, and the current status of programmed death-ligand 1 and TIL testing across different continents.
[npj Breast Cancer] |
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| Breast cancer is immunogenic and a variety of vaccines have been designed to boost immunity directed against the disease. Newer approaches are designing vaccines to prevent breast cancer by intercepting high-risk lesions such as ductal carcinoma in situ to limit the progression of these tumors to invasive cancer.
[Breast Cancer Research and Treatment] |
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| G1 Therapeutics, Inc. announced that the company has initiated a Phase II, single arm, open-label study of trilaciclib in patients with early-stage TNBC designed to further investigate the role of trilaciclib in modulating the anti-tumor immune response.
[G1 Therapeutics, Inc.] |
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| January 9 – 12, 2022
Portland, Oregon, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Georgetown University School of Medicine – Washington, District of Columbia, United States |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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