 | | Vol. 13.45 – 9 December, 2021 |
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| Investigators showed that the deletion of the long noncoding RNA Neat1 in MMTV-PyVT mice profoundly impaired tumor initiation, growth, and metastasis, specifically switching off the penultimate step of glycolysis.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors illustrated how pregnancy-induced changes modulated the communication between mammary epithelial cells and the immune microenvironment and established a causal link between pregnancy, the immune microenvironment, and mammary oncogenesis.
[Cell Reports] |
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| Scientists found that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor FDI-6 could sensitize BRCA-proficient TNBC to PARP inhibitor Olaparib in vitro and in vivo.
[Cell Death & Disease] |
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| Investigators tested the activity of co-targeting of estrogen receptor, HER2, and cyclin-dependent kinases 4/6 therapy with tucatinib, palbociclib, and fulvestrant in HR+/HER2+ human breast tumor cell lines and xenograft models.
[Molecular Cancer therapeutics] |
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| Scientists observed that expression of a construct derived from the N-terminus of Syntaxin4 (Stx4), which interfered with Stx4-Munc18c interaction, led to perturbed trafficking of MT1-MMP, and reduced invadopodium-based invasion in vitro, in models of TNBC.
[Molecular Cancer Research] |
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| For the development of anticancer drugs with higher activity and reduced toxicity, two approaches were combined: preparation of platinum complexes exhibiting higher stability compared to their platinum counterparts and loading them into mesoporous silica SBA-15.
[Dalton Transactions] |
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| Non-coding RNAs including circular RNAs have been reported to be involved in different aspects during tumorigenesis and progression. Scientists explored the biological functions and underlying mechanism of circRPPH1 in breast cancer.
[Cell Death Discovery] |
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| Researchers developed a protocol for processing human adipose derived mesenchymal stem cell secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro using breast cancer cell lines.
[Scientific Reports] |
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| The authors found that a small molecule phenylbutenoid dimer NMac1, a previously identified anti-metastatic agent, had novel anti-proliferative effects only under glucose starvation in metastatic breast cancer cells.
[Scientific Reports] |
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| Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.
[Military Medical Research] |
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| Atypia in breast pathology may be cytonuclear and/or architectural with different applications and implications. Investigators provide a comprehensive review of atypia in breast pathology with reference to inconsistencies, challenges and limitations.
[Pathology] |
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| Scientists review the role of exosomes in the breast cancer (BC) pathophysiology, diagnosis, and therapy as well as the role of tumor derived exosomes in the mechanistic pathways of BC metastasis, immunosuppression, migration, dormancy and chemo-resistance.
[Life Sciences] |
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| The authors review previous research on the correlation between chronic stress and the occurrence and development of breast cancer, particularly the molecular mechanism through which chronic stress promotes breast cancer via neurotransmitters secreted by the nervous system.
[Translational Oncology] |
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| New results from the DESTINY-Breast03 Phase III trial showed that Enhertu demonstrated a higher progression-free survival and objective response rate in pre-specified patient subgroups compared to trastuzumab emtansine in patients with HER2-positive unresectable and/or metastatic breast cancer.
[AstraZeneca] |
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| January 16 – 20, 2022
Banff, Alberta, Canada |
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| | The University of Manchester – Manchester, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Georgetown University School of Medicine – Washington, District of Columbia, United States |
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