 | | Vol. 14.00 – 6 January, 2022 |
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| Researchers uncovered a previously unrecognized mechanistic role for MORC family CW-type zinc finger 2 (MORC2) O-GlcNAcylation in breast cancer progression and provided evidence for targeting MORC2-dependent breast cancer through blocking its O-GlcNAcylation.
[Cell Death & Differentiation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.
[Theranostics] |
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| The authors developed a Gata3 depleted mammary tumor model system to determine the role of Gata3 loss in controlling cell proliferation and aberrant differentiation in mammary tumor development and progression.
[Theranostics] |
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| Scientists found that PBX3-activated DLG1-AS1 could promote the proliferation, invasion and migration of TNBC cells by sponging miR-16-5p and elevating JARID2 expression.
[Molecular Therapy Oncolytics] |
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| The authors identified that FKBP4/NR3C1 axis was a novel negative regulator of TMEM173 in human breast cancer (BC) cells and demonstrated that FKBP4/NR3C1/TMEM173 signaling pathway could regulate autophagy and proliferation of BC cells as well as dendritic cell abundance through exosome release.
[Molecular Therapy Oncolytics] |
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| Investigators elucidated the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provided evidence for the connection between its metabolic actions and the suppression of breast cancer.
[Journal of Experimental & Clinical Cancer Research] |
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| The stemness of OAcGD2+ cells isolated by sorting and the effects of mAb8B6 were assessed by cancer stem cell growth and mammosphere formation in vitro and tumor growth in vivo using patient-derived xenograft models.
[Frontiers in Immunology] |
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| Researchers explored whether circCCDC85A could function as a miR-550a-5p sponge and influence breast cancer progression and found novel evidence that circCCDC85A inhibited the progression of breast cancer by functioning as a molecular sponge of miR-550a-5p to enhance MOB1A expression.
[Breast Cancer Research] |
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| Breast cancer cells were transfected with N-glycosylation mutation EpCAM plasmid to express deglycosylated EpCAM. Investigators showed that deglycosylated EpCAM promoted autophagy in breast cancer cells.
[Aging] |
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| Scientists demonstrated that chrysin impaired genomic stability in MCF-7 and BT474 cells, inhibited cell survival and enhanced the sensitivity of MCF-7 cells to chemotherapeutic drugs.
[Cell Cycle] |
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| Oncobiosis in breast cancer supports invasion, metastasis, and recurrence by supporting cellular movement, epithelial-to-mesenchymal transition, cancer stem cell function, and diapedesis. The microbiome provides novel leverage on breast cancer that should be exploited for better management.
[Cancer and Metastasis Reviews] |
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| Zai Lab Limited announced that the China National Medical Products Administration (NMPA) has accepted the New Drug Application (NDA) for margetuximab, an investigational, Fc-engineered monoclonal antibody that targets HER2.
[Zai Lab Limited] |
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| February 6 – 10, 2022
Banff, Alberta, Canada |
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| | Charity-University Medicine Berlin – Berlin, Germany |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Leiden University – Leiden, United Kingdom |
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| | The University of Manchester – Manchester, United Kingdom |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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