Mammary Cell News Volume 14.02 | Jan 20 2022

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    2022-01-20 | MCN 14.02


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.02 – 20 January, 2022
    TOP STORY

    Single-Cell Analysis of Somatic Mutation Burden in Mammary Epithelial Cells of Pathogenic BRCA1/2 Mutation Carriers

    Investigators used an accurate, single-cell whole genome sequencing approach to show that telomerized primary mammary epithelial cells heterozygous for a highly penetrant BRCA1 variant displayed a robustly elevated mutation frequency as compared to their isogenic control cells.
    [Journal of Clinical Investigation]

    AbstractFull Article
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Low Glucose-Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer

    Researchers revealed a critical role for HOXC-AS3 in regulating the metabolic reprogramming of breast cancer cells under metabolic stress.
    [Cancer Research]

    Abstract

    Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors

    Investigators analyzed lineage-dependent gene expression in human breast tumors to identify differences in metabolic gene expression that may limit pathway redundancy and create therapeutic vulnerabilities.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Coordinate Control of Basal Epithelial Cell Fate and Stem Cell Maintenance by Core EMT Transcription Factor Zeb1

    The authors reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition (EMT), for mammary epithelial ductal side branching and for basal cell regenerative capacity.
    [Cell Reports]

    AbstractFull ArticleGraphical Abstract

    STAT3 Induces Breast Cancer Growth via ANGPTL4, MMP13 and STC1 Secretion by Cancer Associated Fibroblasts

    Researchers demonstrated that STAT3 was essential for the pro-tumorigenic functions of murine breast cancer associated fibroblasts both in vitro and in vivo, and identified a STAT3 signature significantly enriched for genes encoding for secreted proteins.
    [Oncogene]

    Abstract

    C/EBPβ Isoform-Specific Regulation of Migration and Invasion in Triple-Negative Breast Cancer Cells

    Scientists showed that reverting the high liver-enriched inhibitory protein (LIP)/liver-enriched activating protein (LAP) ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.
    [npj Breast Cancer]

    Full Article

    Comparative Transcriptional Analyses of Preclinical Models and Patient Samples Reveal MYC and RELA Driven Expression Patterns That Define the Molecular Landscape of IBC

    The authors evaluated the transcriptome of an extended series of inflammatory breast cancer (IBC) preclinical models and performed a comparative analysis with patient samples to determine the extent to which the current models recapitulated the molecular characteristics of IBC observed clinically.
    [npj Breast Cancer]

    Full Article

    Targeting CLK4 Inhibits the Metastasis and Progression of Breast Cancer by Inactivating TGF-β Pathway

    Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal (MES)-like TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.
    [Cancer Gene Therapy]

    Abstract

    Antiproliferative and Proapoptotic Activities of Sea Cucumber H. Leucospilota Extract on Breast Carcinoma Cell Line (SK-BR-3)

    H. leucospilota was collected, the methanolic extract was prepared and in vitro cytotoxicity of H. leucospilota extract in the range of 12.5, 25, 50, 100, and 200 μg/mL concentrations for 48 hours on SK-BR-3 and MCR5 cells was determined.
    [Molecular Biology Reports]

    Abstract

    Herceptin-Conjugated Magnetic Polystyrene-Agsbox Nanoparticles as a Theranostic Agent for Breast Cancer

    Researchers demonstrated selective binding, effective uptake of herceptin (HER)-conjugated magnetic polystyrene-Agsbox nanoparticles into MDA-MB-231and SKBR-3 cell lines with no effect against L929.
    [Journal of Biomaterials Applications]

    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Updates on Breast Biomarkers

    The authors cover the evolution and latest updates of the CAP/ASCO guidelines relevant to ER and HER2 biomarkers in breast cancer.
    [Virchows Archiv]

    Abstract

    A Review of Prognostic and Predictive Biomarkers in Breast Cancer

    By combining established prognostic factors with valid prognostic/predicted biomarkers, scientists can start the journey to personalized treatment for every recently diagnosed breast cancer patient.
    [Clinical and Experimental Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Syapse Extends Collaboration with Pfizer to Continue to Generate Real-World Evidence in Breast Cancer

    Syapse® announced that Pfizer will continue working with Syapse to advance the use of real-world data from the Syapse Learning Health Network™ as an extension of the organizations’ ongoing collaboration. Syapse will maintain clinical abstractions resources to continue to grow the breast cancer data cohort.
    [Syapse®]

    Press Release
    FEATURED EVENT

    Cell Therapy Analytics Symposium

    2 March, 2022
    Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellows – Cancer Research

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Pathologist – Surgical Cases

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Student – Systems Biology

    Charity-University Medicine Berlin – Berlin, Germany

    Postdoctoral Fellowship – Breast Cancer Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Position – Cell and Chemical Biology

    Leiden University – Leiden, United Kingdom

    > See All Jobs

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