 | | Vol. 14.06 – 17 February, 2022 |
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| Researchers demonstrated that Lin28B promoted lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that Lgl1 modulation of Integrin β1 signaling was essential for directional migration and that epithelial branching in invertebrates and the mammary gland was fundamentally distinct.
[Cell Reports] |
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| CircKDM4B inhibited migration and tube formation of human umbilical vein endothelial cells in vitro and angiogenesis in vivo.
[Oncogene] |
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| The authors investigated the expression profiles and biological effects of fascin actin-bundling protein 1 (Fascin) in breast cancer.
[Cell Death & Disease] |
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| Investigators reported that RNF187, a RING family ubiquitin ligase, facilitated breast cancer growth and inhibited apoptosis by modulating P53 signaling.
[Cell Death & Disease] |
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| Researchers identified that only Trastuzumab+Pertuzumab combination therapy, but not when either antibody used in isolation, allowed for the activation of the classical complement pathway, resulting in both direct complement-dependent cytotoxicity as well as complement-dependent cellular phagocytosis of HER2+ breast cancer cells.
[JCI Insight] |
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| The authors explored whether breast cancer cell drug sensitivity to 5-Fluorouracil was related to lncRNA CCAT2-regulated mTOR pathway.
[Journal of Cellular and Molecular Medicine] |
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| Researchers demonstrated approximately 3-fold higher doxorubicin internalization in inflammatory breast cancer cells compared to healthy breast epithelial cells, leading to targeted cell death at concentrations below the IC50 of free doxorubicin.
[Journal of the American Chemical Society] |
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| Angiopep-2 had high loading efficiency of paclitaxel and lapatinib could transport across the in vitro blood–brain barrier model and accumulate in breast cancer cells.
[Scientific Reports] |
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| The authors investigated the effect of 10 serotoninergic receptor ligands on viability of MCF7, SKBR3 and MDA-MB231 breast cancer cells and focused on their potential ability to affect Tamoxifen responsiveness in ER+ cells.
[BMC Cancer] |
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| Scientists review the recent progress of TNBC research in transcriptomics and proteomics to identify possible therapeutic goals and improve the survival of patients with TNBC.
[Journal of Cellular and Molecular Medicine] |
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| The authors provide insight into the mechanistic pathway(s) of doxorubicin at levels found within patients and establish the magnitude of effect for each mechanism.
[Cancer Chemotherapy and Pharmacology] |
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| Paige and Mindpeak announced a distribution partnership, which will enable pathologists to use Mindpeak’s BreastIHC within the Paige Platform. Mindpeak’s BreastIHC is an AI software that reliably and accurately detects, classifies and quantifies breast cancer cells.
[Paige AI] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | University of Vienna – Vienna, Austria |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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