 | | Vol. 14.07 – 24 February, 2022 |
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| RNA-seq analysis and coimmunoprecipitation assays indicated that HTR1A interacted with TRIM21 and PSMD7 to inhibit the degradation of TβRII through the ubiquitin-proteasome pathway.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists explored the therapeutic potential of targeting PTPN2 in TNBC and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival.
[Science Advances] |
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| Researchers uncovered overexpression and gene copy-number alterations of nucleoporin-93 NUP93, a nuclear pore component, in aggressive human mammary tumors.
[Cell Reports] |
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| The authors reported that NUMB exon 9 inclusion, which resulted in production of a protein isoform with an additional 49 amino acids, was a feature of multiple cancer types including all subtypes of breast cancer and correlated with worse progression-free survival.
[Oncogene] |
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| Investigators showed that YTHDF1 was overexpressed in breast cancer cells and clinical tissues specimens.
[Cells & Bioscience] |
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| The authors demonstrated that triple negative breast cancer cell-derived exosomes increased normal fibroblast collagen contraction and migration alongside cancer-associated fibroblasts molecular markers.
[Molecular Therapy-Nucleic Acids] |
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| Researchers assessed the anti-cancer effects of hibernating common carp plasma on 4T1 cancer cells in vitro and in vivo.
[Scientific Reports] |
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| Scientists found that chronic leptin treatment induced a switch from an epithelial to a mesenchymal morphology, partial loss of E-cadherin and gain of vimentin expression.
[Journal of Mammary Gland Biology and Neoplasia] |
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| The authors reported a bank of human patient-derived xenografts and matched organoid cultures from tumors that represented the greatest unmet need: endocrine-resistant, treatment-refractory, and metastatic breast cancers
[Nature Cancer] |
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| More efforts are made to present a comprehensive overview of the recent advances of exosome nanotechnology for breast cancer therapy, including natural exosomes from different cell types.
[Biomaterials Science] |
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| FGFR signaling on epithelial cells is affected by signals from the breast microenvironment, therefore increasing the possibility of breast developmental abnormalities or cancer progression.
[Open Biology] |
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| Positive high-level results from the pivotal DESTINY-Breast04 Phase III trial showed ENHERTU® demonstrated a statistically significant and clinically meaningful improvement in both progression-free survival and overall survival in patients with HER2-low unresectable and/or metastatic breast cancer.
[AstraZeneca plc] |
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| | March 20 – March 25 | Vienna, Austria |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | University of Vienna – Vienna, Austria |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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