 | | Vol. 14.08 – 3 March, 2022 |
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| Investigators reported a comprehensive proteomic study of a 90-case cohort of paired samples of TNBC in quantification, phosphorylation, and DNA-binding capacity.
[Cell Reports] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using breast cancer (BC) sphere cells as a model, researchers showed that BC stem-like cells expressed high levels of Myc, which required the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair.
[Oncogene] |
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| Scientists identified a 21-amino-acid survival-associated micropeptide XBP1SBM, encoded by the long non-coding RNA (lncRNA) MLLT4-AS1, which was upregulated in TNBC tissues and glutamine-deprived TNBC cell lines.
[Oncogene] |
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| Researchers analyzed murine and human tumors and identified a role for Tgfβr2 in governing the molecular aspects of epithelial to mesenchymal transition that occured with Brca1 loss.
[Cell Death & Disease] |
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| The authors reported that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process.
[Cell Death & Disease] |
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| Investigators demonstrated that circular RNA PRKCI (circPRKCI), derived from the PRKCI gene, was elevated in breast cancer tissues and cell lines, especially in TNBC.
[Cell Death Discovery] |
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| The authors investigated the reactivation of p53 in DNA repair mechanisms and the maintenance of genomic stability using PRIMA‑1METAPR‑246 small molecules, in both MDA‑MB‑231 and MCF‑7 breast cancer cell lines.
[Oncology Reports] |
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| Scientists found that the expression level of YAP/TAZ in tamoxifen-resistant MCF7 breast cancer cells was significantly increased compared with that in MCF7 cells.
[Biochemical and Biophysical Research Communications] |
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| To study laminin N-terminus α31 (LaNt α31) function, an adenoviral system was used to induce expression in MCF-7 and MDA-MB-231 cells. 2D cell migration and invasion into collagen hydrogels were not significantly different between LaNt α31 overexpressing cells and control treated cells.
[PLoS One] |
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| Reverse transcription‑quantitative PCR was used to detect the expression levels of DDX11 antisense RNA 1 (DDX11-AS1) and microRNA‑497 in MCF‑7 and MDA‑MB‑231 cells.
[Molecular Medicine Reports] |
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| Investigators illustrate the functions of unconventional post-translational modifications such as acetylation, glycosylation, sumoylation, methylation, ubiquitination, citrullination, and palmitoylation and highlight their impact on the oncogenesis and progression of breast cancer.
[Cell and Bioscience] |
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| The authors provide a summary of current findings on non-coding RNAs (ncRNAs) dysregulation after irradiation and present the function and mechanism of ncRNAs in modulating radiosensitivity or radioresistance of breast cancer cells.
[Molecular Biology Reports] |
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| With a $2 million recruitment grant from the Cancer Prevention and Research Institute of Texas, a University of Houston (UH) researcher will be setting up a lab to develop drugs that will work on traditionally undruggable targets in cancer.
[University of Houston] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | Monash University – Clayton, Australia |
| | | German Cancer Research Center in the Helmholtz Association – Heidelberg, German |
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| | National University of Ireland Galway – Galway, Ireland |
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| | University of Vienna – Vienna, Austria |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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