 | | Vol. 14.09 – 10 March, 2022 |
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| Researchers used a highly physiologically relevant human breast tissue-derived organoid system and provided evidence that replacement bisphenols had protumorigenic effects on the mammary gland at morphologic and proteomic levels.
[Proceedings of the National Academy of Sciences of the United States of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified a 21-amino-acid survival-associated micropeptide XBP1SBM, encoded by the long non-coding RNA (lncRNA) MLLT4-AS1, which was upregulated in TNBC tissues and glutamine-deprived TNBC cell lines.
[Oncogene] |
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| The authors investigated the interaction of ras-related protein in brain (Rab8A) and tropomyosin-related kinase B in regulating the progression of breast cancer. Rab8A was upregulated in breast cancer tissues.
[Cancer Letters] |
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| Investigators found that decreases in N6AMT1 correlated with the extent of DNA N6-methyladenosine (6mA) in clinical breast cancer (BC) tissues and predicted a worse survival of BC patients.
[Cell Death & Disease] |
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| In order to gain insight into pathways that contributed to the divergent sensitivity to chemotherapy, scientists compared the inflammatory profile of two TNBC subtypes treated with docetaxel.
[npj Breast Cancer] |
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| Researchers investigated the effects of inhibiting estrogen receptor (ER) signaling in combination with ionizing radiation in multiple preclinical ER-positive breast cancer models.
[npj Breast Cancer] |
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| The myoepithelial lineage of human breast is comprised of bipotent and multipotent progenitors in ducts and terminal duct lobular units. Investigators assessed whether this heterogeneity impacted on oncogenic PIK3CA transformation.
[Communications Biology] |
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| The authors investigated the expression profile of 48 apoptotic and 35 oxidative gene markers after canady helios cold plasma treatment in six different types of breast cancer cell lines.
[Scientific Reports] |
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| MDA-MB-231-HM cells secreted exosomes enriched matrix metalloproteinase-1 (MMP-1), which could be taken up and enhanced invasion and migration activities of TNBC cells, including MDA-MB-231, MDA-MB-468 and BT549.
[Breast Cancer Research and Treatment] |
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| Investigators discussed possible resistance mechanisms to trastuzumab and introduced mucin 1 (MUC1) as a potential target efficient for overcoming such resistance.
[Cancer Cell International] |
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| Gilead Sciences, Inc. announced results from the Phase III TROPiCS-02 study evaluating Trodelvy® (sacituzumab govitecan-hziy) in patients with HR+/HER2– metastatic breast cancer who received prior endocrine therapy, CDK4/6 inhibitors and two to four lines of chemotherapy.
[Gilead Sciences, Inc.] |
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| April 8 – 13, 2022
New Orleans, Louisiana, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Diagnostisk Center, Rigshospitalet – Copenhagen, Denmark |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Monash University – Clayton, Australia |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, German |
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