 | | Vol. 14.12 – 31 March, 2022 |
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| Scientists investigated the expression profile of circular RNAs in breast cancer MCF-7 cells under hypoxia and normoxia using microarray.
[Molecular Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified and isolated chemoradiotherapy-resistant cancer stem cells in quiescent state with high capacity of tumor-initiation and tumorsphere formation from three types of breast tumors in mice.
[Oncogene] |
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| Investigators elucidated an important role of PIEZO1 in breast cancer and provided key clues for identifying PIEZO1 as a therapeutic target and prognostic biomarker in breast cancer.
[Genomics] |
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| The authors showed that sulforaphane (SFN), including its two isomers of R-SFN and S-SFN, significantly inhibited transforming growth factor-β1-induced migration and invasion in breast cancer cells.
[npj Breast Cancer] |
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| Scientists found that cancer-associated fibroblasts predominantly secreted hepatocyte growth factor (HGF) and activated MET receptor tyrosine kinase in TNBC cells.
[Molecular Cancer Research] |
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| Everolimus in combination with T-DM1 showed strong antitumor effects in HER2-positive breast cancer, both in vitro and in vivo.
[Molecular Cancer Research] |
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| Scientists targeted Monoacylglycerol lipase (MAGL) in TNBCs, using a potent carbamate-based inhibitor AM9928 with prolonged pharmacodynamic effects. AM9928 blocked TNBC cell adhesion and transmigration across human brain microvascular endothelial cells in 3D co-cultures.
[Scientific Reports] |
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| Researchers investigated the toxicity of different phosphate compounds to TNBCs, particularly, MDA-MB-231, and compared it to that of human monocytes, THP-1.
[Scientific Reports] |
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| Investigators sought to alter transcriptional programs by enforcing the expression of the catalytic domain of the methylcytosine dioxygenase TET2 in breast cancer cells.
[Life Science Alliance] |
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| The authors highlight the unique characteristics of invasive lobular carcinoma (ILC) and describe the need for dedicated ILC clinical trials.
[Breast Cancer Research and Treatment] |
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| On-target compounds specific to MCL-1 have demonstrated promising efficacy in preclinical models of breast cancer and show potential to enhance the anti-tumor effect of conventional therapies.
[Cell Cycle] |
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| Paige launched its latest product, Paige Breast Lymph Node, an AI medical device software that helps pathologists detect if breast cancer has metastasized to lymph nodes, concurrent with pathologists’ own interpretive review.
[Paige AI] |
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| June 15 – 18, 2022
San Francisco |
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| | Augusta University – Augusta, Georgia, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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