Mammary Cell News Volume 14.14 | Apr 14 2022

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    2022-04-14 | MCN 14.14


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.14 – 14 April, 2022
    TOP STORY

    H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

    By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.
    [Nature Genetics]

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    Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

    Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Clinically Relevant CHK1 Inhibitors Abrogate Wild-Type and Y537S Mutant ERα Expression and Proliferation in Luminal Primary and Metastatic Breast Cancer Cells

    The authors evaluated if kinases could be new targets for the treatment of luminal primary and metastatic breast cancers.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Nrf2 and NF-κB/NLRP3 Inflammasome Pathways Are Involved in Prototheca bovis Infections of Mouse Mammary Gland Tissue and Mammary Epithelial Cells

    Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.
    [Free Radical Biology and Medicine]

    Full ArticleGraphical Abstract

    LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

    Researchers identified 1127 long non-coding RNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.
    [npj Breast Cancer]

    Full Article

    Diosgenin Derivatives Developed from Pd(II) Catalyzed Dehydrogenative Coupling Exert an Effect on Breast Cancer Cells by Abrogating Their Growth and Facilitating Apoptosis via Regulating the AKT1 Pathway

    Based on the pharmacological importance of diosgenin, the derivatives were exposed to study their effect on breast cancer cells where they significantly reduced the growth of cancer cells and left non-malignant breast epithelial cells unaffected.
    [Dalton Transactions]

    AbstractGraphical Abstract

    A Positive Feedback Loop: RAD18-YAP-TGF-β between Triple-Negative Breast Cancer and Macrophages Regulates Cancer Stemness and Progression

    TGF-β from tumor-associated macrophages activated RAD18 in TNBC to enhance tumor stemness, forming a positive feedback loop. Inhibition of YAP or TGF-β broke this loop and suppressed cancer stemness and proliferation.
    [Cell Death Discovery]

    Full Article

    Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

    Investigators examined the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.
    [Oncology Reports]

    Abstract

    Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells

    Scientists described the use of two chemical modifications, incorporating a neuropilin receptor agonist peptide and a hypoxia-responsive lipid for targeting and release of an encapsulated drug from bovine milk exosomes to TNBC cells.
    [ACS Applied Bio Materials]

    AbstractGraphical Abstract

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    REVIEWS

    Breast Cancer in the Era of Integrating “Omics” Approaches

    The authors investigate the correlation between different “omics” datasets and define the new important key pathway and upstream regulators in breast cancer.
    [Oncogenesis]

    Full Article

    Delineating the Role of Osteoprotegerin as a Marker of Breast Cancer Risk among Women with a BRCA1 Mutation

    Scientists provide a review of the emerging preclinical and epidemiologic evidence implicating the dysregulation of progesterone-mediated receptor activator of nuclear factor κB signaling in the pathogenesis of BRCA1-associated breast cancer.
    [Hereditary Cancer in Clinical Practice]

    Full Article

    INDUSTRY AND POLICY NEWS

    BriaCell Receives FDA Fast Track Approval for Targeted Breast Cancer Immunotherapy

    BriaCell Therapeutics Corp., a clinical-stage biotechnology company specializing in targeted immunotherapies for cancer, announced that the US FDA has granted Fast Track status to BriaCell’s lead candidate, Bria-IMT™, for the treatment of metastatic breast cancer.
    [BriaCell Therapeutics Corp.]

    Press Release

    FEATURED EVENT

    ASGCT 25th Annual Meeting

    May 16 – 19, 2022
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    JOB OPPORTUNITIES

    PhD Studentship – 3D Breast Cancer Models

    Queensland University of Technology – Queensland, Australia

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    Augusta University – Augusta, Georgia, United States

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    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellowship – Pharmacometabolomics

    The University of British Columbia – Vancouver, British Columbia, Canada

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