Mammary Cell News Volume 14.15 | Apr 21 2022

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    2022-04-21 | MCN 14.15


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.15 – 21 April, 2022
    TOP STORY

    Targeted Intervention of NF2–YAP Signaling Axis in CD24-Overexpressing Cells Contributes to Encouraging Therapeutic Effects in TNBC

    CD24high cells accounted for the vast majority of TNBC cells, and were insensitive to Taxol but sensitive to ferroptosis agonists and effectively escaped phagocytosis by tumor-associated macrophages.
    [ACS Nano]

    AbstractGraphical Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    KMT5A-Methylated SNIP1 Promotes Triple-Negative Breast Cancer Metastasis by Activating YAP Signaling

    Researchers identify that smad nuclear-interacting protein 1 (SNIP1) was a non-histone substrate of lysine methyltransferase KMT5A, which underwent KMT5A-mediated mono-methylation and promoted breast cancer cell growth, invasion and lung metastasis.
    [Nature Communications]

    Full Article

    Extracellular Vesicles from Triple Negative Breast Cancer Promote Pro-Inflammatory Macrophages Associated with Better Clinical Outcome

    Scientists showed that TNBCs released extracellular vesicles and soluble molecules promoting monocyte differentiation toward distinct macrophage fates.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Flubendazole Induces Mitochondrial Dysfunction and DRP1-Mediated Mitophagy by Targeting EVA1A in Breast Cancer

    Investigators found that flubendazole impaired the permeability of the mitochondrial outer membrane and mitochondrial function in breast cancer.
    [Cell Death & Disease]

    Full Article

    ROR Activation by Nobiletin Enhances Antitumor Efficacy via Suppression of IκB/NF-κB Signaling in Triple-Negative Breast Cancer

    The authors identified several TNBC cell lines that were sensitive to nobiletin (NOB), by itself or in combination. Cell and xenograft experiments showed that NOB significantly inhibited TNBC cell proliferation and motility in vitro and in vivo.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Aberrant Promoter Methylation Contributes to LRIG1 Silencing in Basal/Triple-Negative Breast Cancer

    Leucine-rich repeat and immunoglobulin-like domain 1 (LRIG1) gene expression, protein abundance, and methylation enrichment were examined by quantitative reverse-transcription PCR, immunoblotting, and methylation immunoprecipitation, respectively, in breast cancer cell lines in vitro.
    [British Journal of Cancer]

    Full Article

    Establishment and Characterization of Equine Mammary Organoids Using a Method Translatable to Other Non-Traditional Model Species

    Researchers established equine mammary organoids (EqMaOs) from cryopreserved mammary tissue, in which mammary tissue fragments were isolated and embedded into a 3D matrix to produce EqMaOs.
    [Development]

    Full Article

    PTHrP Induces STAT5 Activation, Secretory Differentiation and Accelerates Mammary Tumor Development

    Investigators developed a tetracycline-regulated, mouse mammary tumor virus-driven model of parathyroid hormone-related protein (PTHrP) overexpression in mammary epithelial cells.
    [Breast Cancer Research]

    Full Article

    GATA3 and MDM2 Are Synthetic Lethal in Estrogen Receptor-Positive Breast Cancers

    Depletion and pharmacological inhibition of mouse double minute 2 homolog (MDM2) significantly impaired tumor growth in GATA3-deficient models in vitro, in vivo and in patient-derived organoids/xenograft harboring GATA3 somatic mutations.
    [Communications Biology]

    Full Article

    Ketone-Selenoesters as Potential Anticancer and Multidrug Resistance Modulation Agents in 2D and 3D Ovarian and Breast Cancer In Vitro Models

    Scientists tested the anticancer and multidrug resistance modulation activity of 15 selenocompounds. These compounds induced oxidation stress, inhibited P-glycoprotein transport activity and altered ABC gene expression.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Wnt Signaling in Triple-Negative Breast Cancers: Its Roles in Molecular Subtyping and Cancer Cell Stemness and Its Crosstalk with Non-Coding RNAs

    The authors highlight the dysregulation of Wnt signaling in TNBCs and its potential biological roles in molecular subtyping and stemness traits of specific subtypes.
    [Life Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    Health Canada Approves KEYTRUDA®
    (Pembrolizumab) for the Treatment of Adult Patients with High-Risk Early-Stage Triple-Negative Breast Cancer (TNBC) in Combination with Chemotherapy as Neoadjuvant Treatment, and Then Continued as Monotherapy as Adjuvant Treatment after Surgery

    Merck announced that Health Canada has granted approval for KEYTRUDA® (pembrolizumab), Merck’s anti-PD-1 therapy, as a treatment for adult patients with high-risk early-stage TNBC in combination with chemotherapy.
    [Merck & Co., Inc.]

    Press Release
    FEATURED EVENT

    ISSCR 2022 Annual Meeting

    June 15 – 18, 2022
    San Francisco, California, United States

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    JOB OPPORTUNITIES

    PhD Studentship – 3D Breast Cancer Models

    Queensland University of Technology – Queensland, Australia

    Lead Scientist – Cancer Biology

    Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

    Postdoctoral Fellow – Cancer Biology

    Augusta University – Augusta, Georgia, United States

    Postdoctoral Fellow – Chemotherapy Resistance

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellowship – Pharmacometabolomics

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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