 | | Vol. 14.16 – 28 April, 2022 |
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| Researchers showed primary BRCA1 mutant/+ cells exhibited defective BRCA1 localization, high radiosensitivity and an accelerated entry into cell division, but failed to orient their cell division axis.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that BPTF-associated protein of 18 KDa (BAP18) promoted TNBC cell proliferation, migration, and invasion in vitro and xenograft tumor growth and lung colonization in vivo.
[Cell Death & Disease] |
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| The authors observed significantly increased histone chaperone holiday junction recognition protein (HJURP) expression levels in TNBCs compared to other subtypes.
[Cell Death & Disease] |
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| Investigators measured the expression levels of ESR1 and ESR2 genes in immortalized mammary epithelial cells and different breast cancer cell lines.
[Frontiers in Oncology] |
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| Researchers isolated a tumorigenic cell line which exhibited mesenchymal characteristics, after inoculating Ha-Ras-expressing retrovirus into mammary glands of rats, and subsequently isolated a non-aggressive revertant cell line.
[Cancer Gene Therapy] |
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| Biology and transcriptomes of non-cancerous human mammary epithelial cells at risk for breast cancer development were explored following primary isolation.
[Scientific Reports] |
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| Hybrid molecules exhibited anti-tumor efficacy in reducing tumor growth and metastases in an aggressive model of TNBC.
[Scientific Reports] |
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| Scientists investigated the expression of ribosome assembly factor partner of NOB1 homolog (PNO1) and its association with the progression of breast cancer in patients.
[Oncology Reports] |
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| Researchers showed that eupaformosanin, a natural compound isolated from Eupatorium cannabinum Linn., significantly inhibited the viability of TNBC cells.
[European Journal of Pharmacology] |
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| The authors explored the roles and underlying mechanisms of miR-1290 in determining the sensitivity of TNBC to radiation therapy.
[Clinical and Translational Oncology] |
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| Investigators review studies examining the heterogeneity of cancer-associated fibroblasts (CAFs) in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.
[Cancer Communications] |
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| The authors emphasize the multiple exosomes from a variety of cell sources in constructing nanoplatforms for breast cancer therapy
[Frontiers in Oncology] |
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| HiberCell announced that the first patients have been dosed in a Phase II clinical trial of odetiglucan plus KEYTRUDA® for the treatment of metastatic, hormone-refractory breast cancer in adults.
[HiberCell, Inc. (GlobalNewsWire, Inc.)] |
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| AstraZeneca and Daiichi Sankyo’s ENHERTU® has been granted Breakthrough Therapy Designation in the US for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received a prior systemic therapy.
[AstraZeneca plc] |
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| June 20 – 23, 2022
Sevilla, Spain |
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| | Luxembourg Institute of Health – Strassen, Luxembourg |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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| | City of Hope – Irvine, California, United States |
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