 | | Vol. 14.29 – 4 August, 2022 |
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| The authors demonstrated that spontaneous TNBC tumors from a genetically engineered mouse model, multiple patient-derived xenografts, and archival patient samples exhibited large populations in vivo of hybrid E/M cells that led invasion ex vivo while expressing both epithelial and mesenchymal characteristics.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators isolated multiple distinct single-cell clones from the SUM149PT human breast cell line spanning the epithelial-to-mesenchymal transition (EMT) spectrum having diverse migratory, tumor-initiating, and metastatic qualities, including three unique intermediates.
[Science Advances] |
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| A synergistic immunotherapy strategy for breast cancer incorporating immune cell infiltration, immunogenic cell death, and dendritic cell maturation through a reactive oxygen species-responsive dual-targeted smart nanosystem for the simultaneous release of DOX, R848, and MIP-3α in the tumor microenvironment was reported.
[Bioengineering & Translational Medicine] |
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| Dual inhibition of enhancer of zeste homolog 2 (EZH2) methyltransferase and p38 kinase activities downregulated pEZH2-T367, H3K27me3, and p-p38 pathways in vivo, and reduced TNBC growth and metastasis.
[iScience] |
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| CircPDSS1 was upregulated in breast cancer (BC) cells, and circPDSS1 knockdown repressed BC cell malignant behaviors.
[Cancer Cell International] |
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| Researchers demonstrated that the isogenic 4T1 and 67NR breast cancer cells sorted from each other in 3D spheroids, followed by cooperative invasion.
[Communications Biology] |
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| Scientists presented an image processing and segmentation pipeline for the detection of 3D GFP-fluorescent TNBC cell nuclei, and they performed quantitative analysis of the formed spatial patterns and their temporal evolution.
[Annals of Biomedical Engineering] |
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| Researchers examined the effect of glucose as well as its deprivation, and antagonism using the non-metabolized analogue 2-deoxy glucose, on the proliferation of several breast cancer cell lines MCF7, MDA-MB-231, YS1.2 and pII and one normal breast cell line, using the MTT assay.
[PLoS One] |
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| Investigators compile the current knowledge demonstrating the altered expression of splicing variants and spliceosomal components in breast cancer, showing the existence of a growing body of evidence supporting the close implication of the alteration in the splicing process in mammary tumorigenesis.
[Endocrine-Related Cancer] |
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| Qualigen Therapeutics, Inc. announced it has completed its in vivo efficacy analysis of QN-247 in solid tumors. Data demonstrated robust efficacy and no safety signals in a TNBC model.
[Qualigen Therapeutics, Inc.] |
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| FLAMINGO-01 is a Phase III clinical trial designed to evaluate the safety and efficacy of GLSI-100 in HER2/neu positive breast cancer patients who had residual disease or high-risk pathologic complete response at surgery and who have completed both neoadjuvant and postoperative adjuvant trastuzumab based treatment.
[Greenwich LifeSciences, Inc.] |
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| October 24 – 26, 2022
Madrid, Spain |
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| Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Hershey College of Medicine – Hershey, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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