Mammary Cell News Volume 14.30 | Aug 18 2022

Vol. 14.30 – 18 August, 2022 TOP STORY A Complex Epigenome-Splicing Crosstalk Governs Epithelial-to-Mesenchymal Transition in Metastasis and Brain Development Researchers discovered that a C2H2 zinc finger protein, ZNF827, is strongly induced during various contexts of epithelial-to-mesenchymal transition (EMT), including in brain development and breast cancer metastasis. [Nature Cell Biology] Full Article PUBLICATIONSRanked by the impact factor of the journal Breast Cancer Cell-Derived MicroRNA-155 Suppresses Tumor Progression via Enhancing Immune Cell Recruitment and Anti-Tumor Function Scientists interrogated the impact of tumor miR-155 expression, particularly cancer cell-derived miR-155, on anti-tumor immunity in breast cancer. [Journal of Clinical Investigation] AbstractFull ArticleGraphical Abstract A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer Biochemical assays demonstrated that one of two novel peptide inhibitors of PELP1, PIP1, directly interacted with PELP1 to block PELP1 oncogenic functions. [Cancer Research] Abstract A Specific JMJD6 Inhibitor Potently Suppresses Multiple Types of Cancers Both In Vitro and In Vivo The authors reported that iJMJD6, a specific small-molecule inhibitor of JMJD6 with favorable physiochemical properties, inhibited the enzymatic activity of JMJD6 protein both in vitro and in cultured cells. [Proceedings of the National Academy of Sciences of the United States of America] Full Article Radiation Enhances the Efficacy of EGFR-Targeted CAR-T Cells against Triple-Negative Breast Cancer by Activating NF-κB/Icam1 Signaling Mechanistically, radiation significantly increased Icam1 expression on TNBC cells via activating nuclear factor κB (NF-κB) signaling, thereby promoting chimeric antigen receptor T cell infiltration and killing. [Molecular Therapy] AbstractGraphical Abstract PACT Promotes the Metastasis of Basal-Like Breast Cancer through Rac1 SUMOylation and Activation Scientists screened out protein activator of the interferon-induced protein kinase as an essential gene in basal-like breast cancers metastasis. [Oncogene] Abstract PI3K-Activated MSC Proteomes Inhibit Mammary Tumors via Hsp90ab1 and Myh9 In an ex vivo assay, the size of freshly isolated human breast cancer tissues, including ER-positive & negative as well as HER2-positive & negative, was reduced by YS49-treated mesenchymal stem cell (MSC) derived conditioned medium. [Molecular Therapy Oncolytics] AbstractFull ArticleGraphical Abstract Diltiazem Inhibits Breast Cancer Metastasis via Mediating Growth Differentiation Factor 15 and Epithelial-Mesenchymal Transition By using both mouse and human TNBC cell lines, investigators found that diltiazem decreased colony formation and cell migration in breast cancer cells. [Oncogenesis] Full Article Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment via the miR-125b/HIF1α Signaling Pathway The authors suggested a novel strategy to treat triple negative breast cancer (TNBC) using mesenchymal stem cell-derived extracellular vesicles to transform the behaviors and cellular communication of TNBC cells with other non-cancer cells related to tumorigenesis and metastasis. [Scientific Reports] Full Article REVIEWS Adipocyte Plasticity in Tissue Regeneration, Repair, and Disease The author discusses the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues: skin, heart, skeletal muscle, and mammary gland. [Current Opinion in Genetics & Development] Full ArticleGraphical Abstract INDUSTRY AND POLICY NEWS Sanofi Trial Failure Halts Work on Breast Cancer Treatment Amcenestrant Sanofi has stopped further work on amcenestrant, a treatment once seen to have strong commercial potential in breast cancer, after a second trial failure. [Reuters] Press Release Propanc Biopharma Receives Notice of Allowance for Proenzyme Compositions to Treat Cancer from the European Patent Office Propanc Biopharma, Inc. today announced that a Notice of Allowance has been received from the European Patent Office for claims involving compositions of proenzymes to treat cancer. [Business Wire] Press Release FEATURED EVENT Cell Bio 2022 December 3-7, 2022 Washington, DC, United States > See All Events JOB OPPORTUNITIES Postdoctoral Researcher – Stem Cell and Cancer Biology University of California Santa Cruz – Santa Cruz, California, United States Postdoctoral Researcher – Cancer and Stem Cell Biology Stanford Medicine – Stanford, California, United States Research Associate Professor – Breast Cancer Metastasis Albert Einstein College of Medicine – Bronx, New York, United States Postdoctoral Researcher – Brain Metastasis from Lung and Breast Cancers Hershey College of Medicine – Hershey, Pennsylvania, United States Postdoctoral Position – Cancer Research Albert Einstein College of Medicine – Bronx, New York, United States > See All Jobs Brought to you by Science News Mammary Cell News Archives Contact Us

On Thu, Aug 18, 2022 at 3:46 PM Laurisa Dohm wrote:

Vol. 14.30 – 18 August, 2022 TOP STORY A Complex Epigenome-Splicing Crosstalk Governs Epithelial-to-Mesenchymal Transition in Metastasis and Brain Development Researchers discovered that a C2H2 zinc finger protein, ZNF827, was strongly induced during various contexts of epithelial-to-mesenchymal transition, including in brain development and breast cancer metastasis. [Nature Cell Biology] Full Article PUBLICATIONSRanked by the impact factor of the journal Breast Cancer Cell-Derived MicroRNA-155 Suppresses Tumor Progression via Enhancing Immune Cell Recruitment and Anti-Tumor Function Scientists interrogated the impact of tumor miR-155 expression, particularly cancer cell-derived miR-155, on anti-tumor immunity in breast cancer. [Journal of Clinical Investigation] AbstractFull Article A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer Biochemical assays demonstrated that one of these peptides, PIP1, directly interacted with PELP1 to block PELP1 oncogenic functions. [Cancer Research] Abstract A Specific JMJD6 Inhibitor Potently Suppresses Multiple Types of Cancers Both In Vitro and In Vivo The authors reported that iJMJD6, a specific small-molecule inhibitor of JMJD6 with favorable physiochemical properties, inhibited the enzymatic activity of JMJD6 protein both in vitro and in cultured cells. [Proceedings of the National Academy of Sciences of the United States of America] Full Article Radiation Enhances the Efficacy of EGFR-Targeted CAR-T Cells against Triple-Negative Breast Cancer by Activating NF-κB/Icam1 Signaling Mechanistically, radiation significantly increased Icam1 expression on TNBC cells via activating nuclear factor κB (NF-κB) signaling, thereby promoting chimeric antigen receptor T cell infiltration and killing. [Molecular Therapy] AbstractGraphical Abstract PACT Promotes the Metastasis of Basal-Like Breast Cancer through Rac1 SUMOylation and Activation Scientists screened out protein activator of the interferon-induced protein kinase as an essential gene in basal-like breast cancers metastasis. [Oncogene] Abstract PI3K-Activated MSC Proteomes Inhibit Mammary Tumors via Hsp90ab1 and Myh9 In an ex vivoassay, the size of freshly isolated human breast cancer tissues, including ER-positive & negative as well as HER2-positive & negative, was reduced by YS49-treated mesenchymal stem cell (MSC) derived conditioned medium. [Molecular Therapy Oncolytics] AbstractFull ArticleGraphical Abstract Diltiazem Inhibits Breast Cancer Metastasis via Mediating Growth Differentiation Factor 15 and Epithelial-Mesenchymal Transition By using both mouse and human TNBC cell lines, investigators found that diltiazem decreased colony formation and cell migration in breast cancer cells. [Oncogenesis] Full Article Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment via the miR-125b/HIF1α Signaling Pathway The authors suggested a novel strategy to treat triple negative breast cancer (TNBC) using mesenchymal stem cell-derived extracellular vesicles to transform the behaviors and cellular communication of TNBC cells with other non-cancer cells related to tumorigenesis and metastasis. [Scientific Reports] Full Article REVIEWS Adipocyte Plasticity in Tissue Regeneration, Repair, and Disease The author discusses the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues: skin, heart, skeletal muscle, and mammary gland. [Current Opinion in Genetics & Development] Full ArticleGraphical Abstract INDUSTRY AND POLICY NEWS Sanofi Trial Failure Halts Work on Breast Cancer Treatment Amcenestrant Sanofi has stopped further work on amcenestrant, a treatment once seen to have strong commercial potential in breast cancer, after a second trial failure. [Reuters] Press Release Propanc Biopharma Receives Notice of Allowance for Proenzyme Compositions to Treat Cancer from the European Patent Office Propanc Biopharma, Inc. today announced that a Notice of Allowance has been received from the European Patent Office for claims involving compositions of proenzymes to treat cancer. [Business Wire] Press Release FEATURED EVENT Cell Bio 2022 December 3-7, 2022 Washington, DC, United States > See All Events JOB OPPORTUNITIES Postdoctoral Researcher – Stem Cell and Cancer Biology University of California Santa Cruz – Santa Cruz, California, United States Postdoctoral Researcher – Cancer and Stem Cell Biology Stanford Medicine – Stanford, California, United States Research Associate Professor – Breast Cancer Metastasis Albert Einstein College of Medicine – Bronx, New York, United States Postdoctoral Researcher – Brain Metastasis from Lung and Breast Cancers Hershey College of Medicine – Hershey, Pennsylvania, United States Postdoctoral Position – Cancer Research Albert Einstein College of Medicine – Bronx, New York, United States > See All Jobs Brought to you by Science News Mammary Cell News Archives Contact Us