 | | Vol. 14.31 – 25 August, 2022 |
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| Researchers identified genome-wide the sites where mitotic DNA synthesis reactions occured when BRCA2 was abrogated.
[Molecular Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors compare intraductal xenografts of ER+ and TNBC cells and demonstrate that disseminated TNBC cells proliferate similarly as TNBC cells at the primary site, whereas disseminated ER+ breast cancer cells proliferate slower.
[Nature Communications] |
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| Researchers investigated the primary interaction partners of a protein tyrosine phosphatase (PTPN18) in breast cancer cells, and explored its novel molecular functions.
[Cell Death & Disease] |
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| Scientists identified the induction of an estrogen receptor alpha (ERα) isoform, ERα-LBD, that was encoded by an alternative ESR1 transcript and lacks the activation function and DNA binding domains.
[npj Breast Cancer] |
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| Investigators report (on the cytotoxic effects of) two monoorganotin(IV) complexes based on a dibenzyl phosphinoyldithioformate (H-DBPTF) ligand, containing either bromide (Sn-DBPTF-1) or chloride (Sn-DBPTF-2) anions.
[Dalton Transactions] |
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| Using co-expression analysis of lncRNAs with protein coding genes, scientists discovered three distinct clusters of lncRNAs associated with breast cancer pathogenesis.
[Communications Biology] |
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| The authors investigated Znhit1 and HIF-2α gene expression in breast cancer tissues as well as their relation to cancer stem cell markers LGR5, ALDH1A1 and β-catenin in tissue and serum of breast cancer patients.
[Scientific Reports] |
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| Researchers investigated the expression level of CDCA5 in breast cancer and its effect on breast cancer progression.
[Oncology Reports] |
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| The authors summarized the diverse roles that each STAT family member plays in breast cancer pathobiology, as well as the opportunities and challenges in pharmacologically targeting STAT proteins and their upstream activators in the context of breast cancer treatment.
[Seminars in Cancer Biology] |
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| Unlike the other clinical subtypes, in TNBC we still lack tumor-specific targeted therapy. Early TNBC outcomes have improved due to the intensification of therapies, including improvements in polychemotherapy and the addition of immunotherapy.
[npj Breast Cancer] |
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| | AstraZeneca India has received a Drugs Controller General of India (DCGI) approval to market Lynparza (olaparib) as a monotherapy for the adjuvant treatment of adult patients with BRCA-mutated HER2-negative high-risk early breast cancer.
[AstraZeneca (The Pharma Letter)] |
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| | This Phase I, multi-center study arm will investigate evorpacept in combination with ENHERTU®, a HER2 directed antibody-drug conjugate, to determine the safety, tolerability and efficacy of this drug combination.
[ALX Oncology] |
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| | The Breast Cancer Research Foundation Scientific Advisory Board and its Board of Directors recently announced its 2022 research grants, including six funded grants at Yale Cancer Center and Smilow Cancer Hospital.
[Yale School of Medicine] |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
| | | The Institute of Cancer Research – London, UK |
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| | University of California Santa Cruz – Santa Cruz, California, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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