 | | Vol. 14.33 – 08 September, 2022 |
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| Researchers revealed at a single-cell resolution that mesenchymal-like and pluripotency-like programs coordinated dissemination and a long-lived dormancy program of early disseminated cancer cells.
[Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that p16 overexpression was associated with reduced antitumor activity of CDK4/6 inhibitors in patient-derived xenografts and estrogen receptor-positive breast cancer cell lines.
[Nature Communications] |
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| Using transcriptomic and proteomic approaches in human and murine basal-like breast cancer cells (BLBC), scientists investigated the molecular mechanisms underlying aggressive and chemotherapy-resistant phenotypes in BLBC mammary tumors.
[Cell Death & Disease] |
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| Researchers studied the elongation of very long-chain fatty acids protein 5 (Elovl5) in breast cancer.
[Cell Death & Disease] |
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| Investigators demonstrated that compared to monotherapies, combined Poly (ADP-ribose) polymerase (PARP) inhibition and STING agonism resulted in increased STING pathway activation, greater cytotoxic T cell recruitment, and enhanced dendritic cell activation in BRCA1-deficient breast cancer models.
[npj Breast Cancer] |
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| Bioinformatic analysis, Western blot, immunohistochemistry, CCK-8, colony formation, flow cytometry, wound healing, Transwell, and dual-luciferase reporter assays were performed to explore the role of tumor necrosis factor receptor-related factor interacting protein (TRAIP) in TNBC.
[Cancer Gene Therapy] |
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| Scientists tested anti-cancer drugs on tumor cells from a metastatic breast cancer patient. Circulating tumor cell responses mirrored the impact of drugs on metastatic rather than primary tumors.
[iScience] |
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| Using a mouse model of orthotopic xenograft of the TNBC MDA-MB-231 cells, researchers demonstrated that mineral dust-induced gene (mdig) promoted the growth of primary tumors but inhibited metastasis of these cells in vivo.
[iScience] |
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| Investigators describe changes in the incidence of early-onset cancers globally and suggest measures that are likely to reduce the burden of cancers.
[Nature Reviews Clinical Oncology] |
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| The authors summarize the latest advances in multi-omics tumor profiling, focusing on spatial genomics and chromatin organization, spatial transcriptomics and proteomics, liquid biopsy, and ex vivo modeling of drug response.
[Cancer Cell] |
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| The results of the Next Generation Cancer Immunotherapy: Targeting the Tumor Microenvironment funding call are out. 20 consortia were selected for funding with a total amount of €25.9 million. Two of these were Rosalind and Morris Goodman Cancer Institute researchers, Professors Daniela Quail, and Morag Park.
[McGill Reporter] |
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| December 6 – 10, 2022
San Antonio, Texas, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Gunderson Health System – La Crosse, Wisconsin, United States |
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| | The Institute of Cancer Research – London, UK |
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| | University of California, San Francisco – San Francisco, California, United States |
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