Mammary Cell News Volume 14.34 | Sep 15 2022

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    2022-09-15 | MCN Vol 14.34


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.34 – 15 September, 2022
    TOP STORY

    Connexins Orchestrate Progression of Breast Cancer Metastasis to the Brain by Promoting FAK Activation

    Researchers described a preclinical model of breast cancer metastasis to the brain in mice, and uncovered molecular mechanisms involed in metastatic dissemination and colonization of the brain.
    [Science Translational Medicine]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Error-Prone Repair of Stalled Replication Forks Drives Mutagenesis and Loss of Heterozygosity in Haploinsufficient BRCA1 Cells

    Investigators found that stalled forks were repaired by error-prone pathways, such as microhomology-mediated break-induced replication, in haploinsufficient BRCA1 breast epithelial cells.
    [Molecular Cell]

    AbstractGraphical Abstract

    CDK14 Inhibition Reduces Mammary Stem Cell Activity and Suppresses Triple Negative Breast Cancer Progression

    Scientists investigated the function of cyclin-dependent kinase 14 (CDK14), a member of the Wnt signaling pathway, in mammary development and breast cancer progression.
    [Cell Reports]

    Full ArticleGraphical Abstract

    ZNF276 Promotes the Malignant Phenotype of Breast Carcinoma by Activating the CYP1B1-Mediated Wnt/β-Catenin Pathway

    RNA-sequencing and CUT&Tag assay revealed that ZNF276 controlled a variety of growth and metastasis-related genes expression.
    [Cell Death & Disease]

    Full Article

    Loss of E-Cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

    Researchers generated CRISPR-mediated E-cadherin knockout invasive ductal carcinoma cell lines and investigated the mechanism by which loss of E-cadherin resulted in insulin-like growth factor (IGF) pathway activation.
    [Molecular Cancer Research]

    Abstract

    ADSCs Stimulated by Resistin Promote Breast Cancer Cell Malignancy via CXCL5 in a Breast Cancer Coculture Model

    Investigators utilized a transwell co-culture model containing patient-derived adipose-derived stem cells (ADSCs) and breast cancer cell lines to investigate their potential interaction.
    [Scientific Reports]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Adipose Tissue-to-Breast Cancer Crosstalk: Comprehensive Insights

    The authors introduce the relationship between obesity and breast cancer from two aspects, including factors that promote cancer occurrence or promote metastasis.
    [Biochimica et Biophysica Acta-Reviews On Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Mersana Therapeutics Announces FDA Fast Track Designation Granted to XMT-1660 for the Treatment of TNBC

    Mersana Therapeutics, Inc. announced that the US FDA has granted fast track designation to XMT-1660 for the treatment of adult patients with advanced or metastatic TNBC.
    [Mersana Therapeutics, Inc.]

    Press Release

    OncXerna Therapeutics Doses First Patient in Phase II Trial Evaluating Navicixizumab Alone or in Combination with Chemotherapy in Patients with Select Advanced Solid Tumors

    OncXerna Therapeutics, Inc. announced the initiation of dosing in a trial evaluating the anti-DLL4/VEGF bispecific antibody navicixizumab, in patients with select advanced solid tumors.
    [OncXerna Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    5th International Cancer Symposium

    November 2-4, 2022
    Lyon, France

    > See All Events

    JOB OPPORTUNITIES

    Medical Advisor – Breast Cancer

    AstraZeneca – Mississauga, Ontario, Canada

    Senior Research Fellow – Breast Cancer Prevention

    University of Sydney – Camperdown, Australia

    Senior Scientific Officer – Target Validation and DNA Damage

    The Institute of Cancer Research – London, UK

    Postdoctoral Researcher – Stem Cell and Cancer Biology

    University of California Santa Cruz – Santa Cruz, California, United States

    Research Associate Professor – Breast Cancer Metastasis

    Albert Einstein College of Medicine – Bronx, New York, United States

    > See All Jobs

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