 | | Vol. 14.35 – 22 September, 2022 |
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| By imaging single-cell ERK activity dynamics in MCF10A acini, researchers found that mammary epithelial acinar morphogenesis fates depended on the average frequency of non-periodic ERK pulses.
[Developmental Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified the long noncoding RNA TGFB2-AS1 as an important regulator of the reversibility and plasticity of noncancer stem cell populations in TNBC.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists identified srGAP1 as a regulator of a proliferative-to-invasive switch in breast cancer cells, and high-resolution light-sheet microscopy demonstrated that these cells could switch form actin-rich protrusions during extravasation.
[Cell Reports] |
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| Investigators showed that pharmacological inhibition or knock down of MCL-1 in primary breast ancer-associated fibroblasts directly derived from human samples mitigated myofibroblastic features.
[Cell Death & Disease] |
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| Researchers demonstrated that Nucleolin (NCL) was a novel interacting partner of Orai1. NCL is a multifunctional nucleocytoplasmic protein and is upregulated in human breast tumors.
[Oncogenesis] |
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| Investigators identified a potent microRNA, miR-570 that could bind the 3′untranslated regions of multiple heat shock protein (HSP) mRNAs and inhibit HSP synthesis.
[Scientific Reports] |
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| The authors evaluated standardized incidence ratios for overall second priamary cancerss, site-specific risks, by age at breast cancer onset, time since breast cancer onset, and geographic region.
[Epidemiology] |
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| The grant from the NIH’s National Cancer Institure will establish the Center for Systems Analysis of Stress-Adapted Cancer Organelles.
[University of Virginia] |
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| The Cancer Prevention and Research Institute of Texas has released three grant research funding awards to research projects at the University of Texas at Austin College of Pharmacy.
[University of Texas] |
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| November 6 – 8, 2022
Seville, Spain |
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| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| | University of Sydney – Camperdown, Australia |
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| | Salk Institute – La Jolla, California, United States |
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| | AstraZeneca – Mississauga, Ontario, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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