 | | Vol. 14.39 – 20 October, 2022 |
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| Researchers demonstrated that NHE1 and SWELL1 preferentially polarized at the cell leading and trailing edges, respectively, mediated cell volume regulation, cell dissemination from spheroids, and confined migration.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The in vitro tumor spheroid model established in this study mimicked the evolution of ER+ to ER– human breast cancer, and provided a useful model for future investigation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists reported the discovery of a novel small molecule inhibitor (NSC33353) with potent anti-tumor activity against TNBC cells. The anti-proliferative effects of this small molecule inhibitor were determined using 2D and 3D cell proliferation assays.
[Oncogene] |
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| Parallel CRISPR screens in three PTEN-null breast cancer cell lines identified genes mediating resistance to capivasertib (AKT inhibitor) and AZD8186 (PI3Kβ inhibitor). The dominant mechanism causing resistance was reactivated PI3K-AKT-mTOR signaling, but not other canonical signaling pathways.
[Oncogene] |
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| Clip170 tension observed by a newly designed cpstFRET tension probe was suggested to be positively related to breast cancer aggressiveness, which could be regulated by α-tubulin detyrosination-induced microtubule disassembly.
[Cell Death & Disease] |
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| Cellular functional assays which aimed to evaluate cell proliferation, migration, invasion, and apoptosis, were conducted to investigate the oncogenic activity of COL10A1 in breast cancer.
[Heliyon] |
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| The authors summarize our current knowledge of ductal carcinoma in situ (DCIS) and explore open questions about the basic biology of DCIS, including those regarding how genomic events in neoplastic cells and the surrounding microenvironment contribute to the progression of DCIS to invasive breast cancer.
[Nature Reviews Cancer] |
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| Uğur Şahin and Özlem Türeci say the mRNA technology at the heart of BioNTech’s Covid vaccine could be repurposed so that it primed the immune system to attack cancer cells instead of invading coronaviruses.
[The Guardian] |
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| The American Cancer Society, the largest non-government, non-profit funding source of cancer research in the US, has approved funding for 89 new Extramural Discovery Science research grants totaling $54.3 million.
[American Cancer Society] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | Nature Communications – London, Berlin, New York, Shanghai (Hybrid) |
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| | NCI – Bethesda, Maryland, United States |
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| | Merck & Co., Inc. – North Wales, Pennsylvania, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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