 | | Vol. 14.42 – 17 November, 2022 |
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| An abundance of CD16+ fibroblasts in HER2+ breast cancer patients was associated with poor prognosis and response to trastuzumab. Functionally, upon trastuzumab stimulation, CD16+ fibroblasts reduced drug delivery by enhancing extracellular matrix stiffness.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists incorporated cell hierarchy to study functional diversity at subpopulation, club, and cell layers. Accordingly, they implemented a package, SEAT, to construct cell hierarchies utilizing structure entropy by minimizing the global uncertainty in cell–cell graphs.
[Nucleic Acids Research] |
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| The obtained aptamer, named apMNKQ2, was able to inhibit proliferation, colony formation, migration and invasion in breast cancer cells.
[Molecular Therapy Nucleic Acids] |
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| | Two oncolytic Urabe mumps virus clinical trial virus stock (MuV-U-Japan) isolates, MuV-UA and MuV-UC, potently killed a panel of established human breast cancer cell lines in vitro, and significantly extended survival of nude mice with human TNBC MDA-MB-231 tumor xenografts in vivo. |
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| Investigators tested the pro-oncogenic role of heterogeneous nuclear ribonucleoprotein U (HNRNPU), which could induce the proliferation and migration of TNBC cells via its association with DEAD box helicase 5 protein.
[Cell Death & Disease] |
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| Scientists tracked the temporal variations in natural killer—triple-negative breast cancer cell distances and compared them with terminal cellular transcriptome profiles.
[Communications Biology] |
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| DEAR1 loss in human mammary epithelial cells resulted in significantly enhanced mammosphere formation that was accelerated in the presence of TGF-β/SMAD3 signaling.
[Scientific Reports] |
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| To confirm Aromatase Interacting Partner in Breast (AIPB)’s regulatory role, investigators developed a conditional expression of AIPB by stably selecting with puromycin from MCF-7 cells and thus regulating AIPB expression under a tetracycline promoter.
[Journal of Endocrine Society] |
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| Scientists showed that either prior PDIA3-inhibition by the disulphide isomerase inhibitor 16F16 or depletion of heparin-binding proteins strongly reduced the activity of conditioned medium of MDA-MB-231 human breast cancer cells to support pro-migratory cell spreading by newly adherent MDA-MB-231 cells.
[American Journal of Physiology-Cell Physiology] |
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| Researchers investigated the intricate involvement of serine/threonine kinase in breast cancer cells and their disruption by phenethyl isothiocyanate (PEITC).
[Heliyon] |
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| The authors highlight current data and ongoing efforts to establish the safety and efficacy of immunotherapeutic approaches beyond checkpoint inhibitors in TNBC.
[npj Breast Cancer] |
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| Biocept, Inc. announced a collaboration agreement to participate in an investigator-initiated, non-therapeutic pilot study to evaluate the cerebrospinal fluid tumor and immune cell microenvironment in patients with metastatic breast cancer and brain metastases and/or leptomeningeal disease.
[Biocept, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Breast Cancer Research Foundation – New York, New York, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | AstraZeneca – Mississauga, Ontario, Canada |
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