 | | Vol. 14.44 – 24 November, 2022 |
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| Mesoporous silica nanoparticles loaded with the senescence inductor palbociclib, and coated with a heterobifunctional poly(ethylene glycol) that binds covalently to a MUC1-binding aptamer, were designed to specifically deliver the pro-senescent drug palbociclib in MDA-MB-231 breast cancer cells.
[Nano Today] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that long-term estrogen deprivation induced DIO3OS expression in estrogen receptor-positive breast tumor cells, which further enhanced aerobic glycolysis and promoted estrogen-independent cell proliferation in vitro and in vivo.
[Nature Communications] |
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| Investigators took advantage of the cancer-associated fibroblast (CAF)-reprogramming capabilities of tranilast, developing tranilast-loaded micelles designed to increase CAF-reprogramming while limiting adverse effects.
[Nature Communications] |
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| CCL18 secreted by tumor-associated macrophages activated a CD10+GPR77+ cancer-associated fibroblast phenotype in normal breast-resident fibroblasts, enriching cancer stem cells and inducing chemoresistance in breast cancer cells.
[Oncogene] |
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| The authors report a first-in-class Annexin A3 (ANXA3)-targeted small molecule (R)-SL18, which demonstrated anti-proliferative and anti-invasive activities to TNBC cells.
[Acta Pharmaceutica Sinica B] |
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| In vivo and in vitro assays demonstrated the anti-tumor efficacy of the rationally designed free-radical nanogenerator in the hypoxic microenvironment of breast cancer without showing systemic toxicity.
[Nanomedicine: Nanotechnology, Biology and Medicine] |
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| Dual luciferase assays, bioinformatics analyses, and chromatin immunoprecipitation assays indicated that transcription factor E2F1 directly bound to the PRSS22 promoter region and activated its transcription. Upregulation of PRSS22 promoted invasion and metastasis of breast cancer cells in vitro and in vivo.
[Cell Death & Disease] |
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| In order to develop potent and selective CYP4Z1 inhibitors, a series of novel N-hydroxyphenylformamidines were rationally designed and synthesized from a pan-CYP inhibitor HET0016.
[Journal of Medicinal Chemistry] |
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| Overexpression of Carboxyl-terminal modulator protein (CTMP) promoted migration and invasion abilities in BT549 cells, while down-regulating of CTMP expression inhibited these abilities in MDA-MB-231 cells.
[Cancer Gene Therapy] |
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| The authors synthesize knowledge about the antitumor effect of melatonin on breast cancer in experimental models and propose the main mechanisms of action already described in relation to the processes regulated by melatonin.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| The University has received a 15 million dollar grant from the National Cancer Institute to develop artificial intelligence that can detect breast cancer and create a risk model. The grant will go towards three different projects towards streamlining, perfecting the diagnosing process, and creating equity in cancer screening.
[The Davis Vanguard] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | Breast Cancer Research Foundation – New York, New York, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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